Glucocorticoids induce differentiation and chemoresistance in ovarian cancer by promoting ROR1-mediated stemness

Glucocorticoids are routinely used in the clinic as anti-inflammatory and immunosuppressive agents as well as adjuvants during cancer treatment to mitigate the undesirable side effects of chemotherapy. However, recent studies have indicated that glucocorticoids may negatively impact the efficacy of...

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Veröffentlicht in:	Cell death & disease 2020-09, Vol.11 (9), p.790-790, Article 790
Hauptverfasser:	Karvonen, Hanna, Arjama, Mariliina, Kaleva, Laura, Niininen, Wilhelmiina, Barker, Harlan, Koivisto-Korander, Riitta, Tapper, Johanna, Pakarinen, Päivi, Lassus, Heini, Loukovaara, Mikko, Bützow, Ralf, Kallioniemi, Olli, Murumägi, Astrid, Ungureanu, Daniela
Format:	Artikel
Sprache:	eng
Schlagworte:	13/89 13/95 14/34 631/67/395 631/67/71 692/699/67/70 82/29 96/1 96/106 96/31 Antibodies Biochemistry Biomedical and Life Sciences Carcinoma, Ovarian Epithelial - drug therapy Carcinoma, Ovarian Epithelial - pathology Cell Biology Cell Culture Cell Differentiation - drug effects Cell Line, Tumor Drug Resistance, Neoplasm - drug effects Female Gene Expression Regulation, Neoplastic - drug effects Glucocorticoids - metabolism Glucocorticoids - pharmacology Humans Immunology Life Sciences Neoplastic Stem Cells - drug effects Neoplastic Stem Cells - metabolism Ovarian Neoplasms - drug therapy Ovarian Neoplasms - genetics Receptor Tyrosine Kinase-like Orphan Receptors - metabolism
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