High-fat diet and estrogen impacts the colon and its transcriptome in a sex-dependent manner

There is a strong association between obesity and colorectal cancer (CRC), especially in men, whereas estrogen protects against both the metabolic syndrome and CRC. Colon is the first organ to respond to high-fat diet (HFD), and estrogen receptor beta (ERβ) can attenuate CRC development. How estroge...

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Veröffentlicht in:	Scientific reports 2020-09, Vol.10 (1), p.16160, Article 16160
Hauptverfasser:	Hases, L., Archer, A., Indukuri, R., Birgersson, M., Savva, C., Korach-André, M., Williams, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/443/319 631/80 692/420/256/2515 692/499 692/699/1503 692/700/2814 Animals Blood Glucose - metabolism Body weight Cell proliferation Cell Proliferation - drug effects Colon - drug effects Colon - metabolism Colorectal cancer Colorectal carcinoma Diet Diet, High-Fat Epithelial cells Estradiol - pharmacology Estrogen Receptor beta - agonists Estrogen receptors Estrogens Female Gender differences Gene expression Gene Expression - drug effects High fat diet Humanities and Social Sciences Infiltration Macrophages Male Medicin och hälsovetenskap Metabolic disorders Metabolic syndrome Mice multidisciplinary Nitriles - pharmacology Obesity - metabolism Science Science (multidisciplinary) Sex Sex differences Sex Factors Transcription activation Transcriptome - drug effects Xenoestrogens
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