Galanin and neuropeptide Y interactions elicit antidepressant activity linked to neuronal precursor cells of the dentate gyrus in the ventral hippocampus

A need for new antidepressants is necessary since traditional antidepressants have several flaws. Neuropeptide Y(NPY) Y1 receptor (NPYY1R) and galanin (GAL) receptor 2 (GALR2) interact in several regions of the limbic system, including the hippocampus. The current study assesses the antidepressant e...

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Veröffentlicht in:	Journal of cellular physiology 2021-05, Vol.236 (5), p.3565-3578
Hauptverfasser:	Borroto‐Escuela, Dasiel O., Pita‐Rodriguez, Mariana, Fores‐Pons, Ramón, Barbancho, Miguel A., Fuxe, Kjell, Narváez, Manuel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antidepressants Antidepressive Agents - metabolism Behavior, Animal Bromodeoxyuridine - metabolism Cell culture Cell growth Cell Membrane - metabolism Cell Proliferation Cells, Cultured Dentate gyrus Dentate Gyrus - metabolism Depression Doublecortin Domain Proteins Doublecortin Protein Endocytosis Extracellular signal-regulated kinase Galanin Galanin - metabolism Hippocampus Kinases Limbic system Male MAP Kinase Signaling System Mental depression Metabolic pathways Microtubule-Associated Proteins - metabolism Neural Stem Cells - metabolism Neuroblasts Neuropeptide Y Neuropeptide Y - metabolism Neuropeptides Neuropeptides - metabolism Pharmacophores Precursors Rats Rats, Sprague-Dawley Receptor interaction Receptor, Galanin, Type 2 - metabolism Receptors Receptors, Neuropeptide Y - agonists Receptors, Neuropeptide Y - metabolism Serum Response Element - genetics Swimming
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