Brain exposure of the ATM inhibitor AZD1390 in humans-a positron emission tomography study

The protein kinase ataxia telangiectasia mutated (ATM) mediates cellular response to DNA damage induced by radiation. ATM inhibition decreases DNA damage repair in tumor cells and affects tumor growth. AZD1390 is a novel, highly potent, selective ATM inhibitor designed to cross the blood-brain barri...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2021-04, Vol.23 (4), p.687-696
Hauptverfasser:	Jucaite, Aurelija, Stenkrona, Per, Cselényi, Zsolt, De Vita, Serena, Buil-Bruna, Nuria, Varnäs, Katarina, Savage, Alicia, Varrone, Andrea, Johnström, Peter, Schou, Magnus, Davison, Chris, Sykes, Andy, Pilla Reddy, Venkatesh, Hoch, Matthias, Vazquez-Romero, Ana, Moein, Mohammad Mahdi, Halldin, Christer, Merchant, Melinda S, Pass, Martin, Farde, Lars
Format:	Artikel
Sprache:	eng
Schlagworte:	Ataxia Telangiectasia Ataxia Telangiectasia Mutated Proteins Blood-Brain Barrier Brain - diagnostic imaging Carbon Radioisotopes Clinical Investigations Humans Male Positron-Emission Tomography
Online-Zugang:	Volltext
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