Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. We did a systematic review and me...

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Veröffentlicht in:	The Lancet (British edition) 2020-11, Vol.396 (10262), p.1574-1584
Hauptverfasser:	Schwamm, Lee H, Leys, Didier, Schellinger, Peter D, Thijs, Vincent, Wahlgren, Nils, Toyoda, Kazunori, Albiker, Christian, Almendrote, Miriam, Amiri, Hemasse, Bodechtel, Ulf, Bojaryn, Urszula, Cho, Tae-Hee, Choy, Lillian, Christensen, Hanne, De Hollander, Isabel, De Smedt, Ann, Dittrich, Ralf, Dusart, Anne, Ebinger, Martin, Fandler, Simon, Foerch, Christian, Gerner, Stefan, Harmel, Peter, Hennerici, Michael, Hermans, Sylvia, Hohenbichler, Katharina, Kallmünzer, Bernd, Kellert, Lars, Kraft, Peter, Lovelock, Caroline, Marzina, Annika, Møller, Anette, Moynihan, Barry, Nederkoorn, Paul, Oberndorfer, Stefan, Oppel, Lorenz, Pérez de la Ossa, Natalia, Remmers, Michel, Sagnier, Sharmilla, Soors, Peter, Turc, Guillaume, Vallet, Pauline, van Eendenburg, Cecile, von Weitzel, Paul, Weber, Claudia, Wollboldt, Christian, Ziemann, Ulf, Zuber, Mathieu, Egashira, Yusuke, Gotoh, Seiji, Ide, Toshihiro, Igarashi, Shuichi, Kanai, Haruka, Koga, Masatoshi, Kusumi, Masayoshi, Nagakane, Yoshinari, Sozu, Takashi, Tanaka, Eijiro, Terada, Tomoaki, Todo, Kenichi, Tsujino, Akira, Yonehara, Toshiro, Chen, W.H., Churilov, L., Coote, S., Coulton, B., Day, S., Desmond, P.M., Huang, H.Y., Jeng, J.S., Kasari, O., Kyndt, C., Lau, C.L., Lim, J.C., Lin, D., Loh, P.S., Low, E., Lu, C.J., Lu, M.K., Ng, J-L., Parsons, M.W., Phan, T., Sturm, J., Tatlisumak, T., Tsai, H.T., Tseng, L.T., Tu, H., Tu, H.T-H., Zhao, H., Bluhmki, Erich, Kala, Lalit, Laage, Rico, Nuñez, Xavier, Carandang, Raphael A., Drake, Kendra, Harris, Gordon J., Muzikansky, Alona, Song, Shlee S., Starkman, Sidney
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers Clinical trials Computed tomography Death Diffusion Magnetic Resonance Imaging - methods Fibrinolytic Agents - adverse effects Fibrinolytic Agents - therapeutic use Hemorrhage Heterogeneity Humans Infusions, Intravenous Intravenous administration Ischemic Stroke - diagnostic imaging Ischemic Stroke - drug therapy Life Sciences Magnetic resonance imaging Medical imaging Meta-analysis Mortality Patients Perfusion Recovery of Function Regression analysis Regression models Stroke Systematic review Thrombolysis Thrombolytic drugs Time-to-Treatment Tissue Plasminogen Activator - adverse effects Tissue Plasminogen Activator - therapeutic use Tomography, X-Ray Computed - methods Treatment Outcome
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