Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors
The disruption of apoptotic cell death process is closely associated with the etiology of various diseases, including cancer. Permanent viral infections can cause different types of cancers. Oncogenic viruses manipulate both external and internal apoptosis pathways, and inhibit the activity of proap...
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| Veröffentlicht in: | Biochemistry (Moscow) 2020-10, Vol.85 (10), p.1191-1201 |
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| container_title | Biochemistry (Moscow) |
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| creator | Zamaraev, A. V. Zhivotovsky, B. Kopeina, G. S. |
| description | The disruption of apoptotic cell death process is closely associated with the etiology of various diseases, including cancer. Permanent viral infections can cause different types of cancers. Oncogenic viruses manipulate both external and internal apoptosis pathways, and inhibit the activity of proapoptotic proteins and signaling pathways, which facilitates carcinogenesis. Ineffective immune surveillance or immune response suppression can induce uncontrolled virus propagation and host cell proliferation. In this review, we discuss current data that provide insights into mechanisms of apoptotic death suppression by viruses and their role in oncogenesis. |
| doi_str_mv | 10.1134/S0006297920100077 |
| format | Article |
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V. ; Zhivotovsky, B. ; Kopeina, G. S.</creator><creatorcontrib>Zamaraev, A. V. ; Zhivotovsky, B. ; Kopeina, G. S.</creatorcontrib><description>The disruption of apoptotic cell death process is closely associated with the etiology of various diseases, including cancer. Permanent viral infections can cause different types of cancers. Oncogenic viruses manipulate both external and internal apoptosis pathways, and inhibit the activity of proapoptotic proteins and signaling pathways, which facilitates carcinogenesis. Ineffective immune surveillance or immune response suppression can induce uncontrolled virus propagation and host cell proliferation. In this review, we discuss current data that provide insights into mechanisms of apoptotic death suppression by viruses and their role in oncogenesis.</description><identifier>ISSN: 0006-2979</identifier><identifier>ISSN: 1608-3040</identifier><identifier>EISSN: 1608-3040</identifier><identifier>DOI: 10.1134/S0006297920100077</identifier><identifier>PMID: 33202204</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>Apoptosis ; Biochemistry ; Biomedical and Life Sciences ; Biomedicine ; Bioorganic Chemistry ; Cancer ; Carcinogenesis ; Carcinogens ; Cell death ; Cell Line, Tumor ; Cell proliferation ; Etiology ; Gene Expression Regulation ; Health aspects ; Humans ; Immune response ; Immune system ; Immunosurveillance ; Life Sciences ; Medicin och hälsovetenskap ; Microbiology ; Mitochondria - metabolism ; NF-kappa B - metabolism ; Oncogenic Viruses - physiology ; Phosphatidylinositol 3-Kinases - metabolism ; Proteins ; Regulators ; Review ; Tumor Suppressor Protein p53 - metabolism ; Tumor Virus Infections - virology ; Tumorigenesis ; Viral infections ; Viruses</subject><ispartof>Biochemistry (Moscow), 2020-10, Vol.85 (10), p.1191-1201</ispartof><rights>Pleiades Publishing, Ltd. 2020</rights><rights>COPYRIGHT 2020 Springer</rights><rights>Pleiades Publishing, Ltd. 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c625t-b09e9832232e14c60e9a1b271bf5c3306f54db1d11ec6662c695433aea519313</citedby><cites>FETCH-LOGICAL-c625t-b09e9832232e14c60e9a1b271bf5c3306f54db1d11ec6662c695433aea519313</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S0006297920100077$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S0006297920100077$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,552,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33202204$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:145048894$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Zamaraev, A. V.</creatorcontrib><creatorcontrib>Zhivotovsky, B.</creatorcontrib><creatorcontrib>Kopeina, G. S.</creatorcontrib><title>Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors</title><title>Biochemistry (Moscow)</title><addtitle>Biochemistry Moscow</addtitle><addtitle>Biochemistry (Mosc)</addtitle><description>The disruption of apoptotic cell death process is closely associated with the etiology of various diseases, including cancer. Permanent viral infections can cause different types of cancers. Oncogenic viruses manipulate both external and internal apoptosis pathways, and inhibit the activity of proapoptotic proteins and signaling pathways, which facilitates carcinogenesis. Ineffective immune surveillance or immune response suppression can induce uncontrolled virus propagation and host cell proliferation. In this review, we discuss current data that provide insights into mechanisms of apoptotic death suppression by viruses and their role in oncogenesis.</description><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Bioorganic Chemistry</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Carcinogens</subject><subject>Cell death</subject><subject>Cell Line, Tumor</subject><subject>Cell proliferation</subject><subject>Etiology</subject><subject>Gene Expression Regulation</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunosurveillance</subject><subject>Life Sciences</subject><subject>Medicin och hälsovetenskap</subject><subject>Microbiology</subject><subject>Mitochondria - metabolism</subject><subject>NF-kappa B - metabolism</subject><subject>Oncogenic Viruses - physiology</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Proteins</subject><subject>Regulators</subject><subject>Review</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><subject>Tumor Virus Infections - virology</subject><subject>Tumorigenesis</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>0006-2979</issn><issn>1608-3040</issn><issn>1608-3040</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>D8T</sourceid><recordid>eNp1kk1v1DAQhiMEotvCD-CCInFO8fgrMQekVUU_pIpKUHG1HGcSXHbtYGeL-Pc42m2XFVQ-eDzzvK88oymKN0BOARh__5UQIqmqFSWQw7p-VixAkqZihJPnxWIuV3P9qDhO6S4_KVHsZXHEGCWUEr4oLr-5aFblle_RTi749KH8jIOZ3D2WX3DYrMwUYipDXy7HME4huVQa35U33oYBvbPlubEz8qp40ZtVwte7-6S4Pf90e3ZZXd9cXJ0trysrqZiqlihUDaOUUQRuJUFloKU1tL2wjBHZC9610AGglVJSK5XgjBk0AhQDdlJUW9v0C8dNq8fo1ib-1sE4vUv9yBFqLqXgPPPqSX6ModuLHoTABeFNo2btx602A2vsLPopz-rQ4qDi3Xc9hHtdC0WErLPBu51BDD83mCZ9FzbR5_FoymtoOBDB99RgVqid70M2s2uXrF5KpmoCQFmmTv9D5dPh2tngsXc5fyCArcDGkFLE_vHjQPS8Pvqf9cmat393_Kh42JcM0N04c8kPGPcdPe36B6XAzgE</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Zamaraev, A. V.</creator><creator>Zhivotovsky, B.</creator><creator>Kopeina, G. 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V. ; Zhivotovsky, B. ; Kopeina, G. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c625t-b09e9832232e14c60e9a1b271bf5c3306f54db1d11ec6662c695433aea519313</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Bioorganic Chemistry</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Carcinogens</topic><topic>Cell death</topic><topic>Cell Line, Tumor</topic><topic>Cell proliferation</topic><topic>Etiology</topic><topic>Gene Expression Regulation</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunosurveillance</topic><topic>Life Sciences</topic><topic>Medicin och hälsovetenskap</topic><topic>Microbiology</topic><topic>Mitochondria - metabolism</topic><topic>NF-kappa B - metabolism</topic><topic>Oncogenic Viruses - physiology</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Proteins</topic><topic>Regulators</topic><topic>Review</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><topic>Tumor Virus Infections - virology</topic><topic>Tumorigenesis</topic><topic>Viral infections</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zamaraev, A. 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| subjects | Apoptosis Biochemistry Biomedical and Life Sciences Biomedicine Bioorganic Chemistry Cancer Carcinogenesis Carcinogens Cell death Cell Line, Tumor Cell proliferation Etiology Gene Expression Regulation Health aspects Humans Immune response Immune system Immunosurveillance Life Sciences Medicin och hälsovetenskap Microbiology Mitochondria - metabolism NF-kappa B - metabolism Oncogenic Viruses - physiology Phosphatidylinositol 3-Kinases - metabolism Proteins Regulators Review Tumor Suppressor Protein p53 - metabolism Tumor Virus Infections - virology Tumorigenesis Viral infections Viruses |
| title | Viral Infections: Negative Regulators of Apoptosis and Oncogenic Factors |
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