Association of CYP2C19 and CYP2D6 Poor and Intermediate Metabolizer Status With Antidepressant and Antipsychotic Exposure: A Systematic Review and Meta-analysis

IMPORTANCE: Precise estimation of the drug metabolism capacity for individual patients is crucial for adequate dose personalization. OBJECTIVE: To quantify the difference in the antipsychotic and antidepressant exposure among patients with genetically associated CYP2C19 and CYP2D6 poor (PM), interme...

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Veröffentlicht in:	JAMA psychiatry (Chicago, Ill.) Ill.), 2021-03, Vol.78 (3), p.270-280
Hauptverfasser:	Milosavljevic, Filip, Bukvic, Nikola, Pavlovic, Zorana, Miljevic, Cedo, Pešic, Vesna, Molden, Espen, Ingelman-Sundberg, Magnus, Leucht, Stefan, Jukic, Marin M
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidepressive Agents - administration & dosage Antidepressive Agents - pharmacokinetics Antipsychotic Agents - administration & dosage Antipsychotic Agents - pharmacokinetics Comments Cytochrome P-450 CYP2C19 - metabolism Cytochrome P-450 CYP2D6 - metabolism Humans Online First Original Investigation Pharmacogenomic Variants - genetics
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