Genetic dissection of a major haplotype associated with arthritis reveal FcγR2b and FcγR3 to act additively

A haplotype with tightly linked Fc gamma receptor (FcγR) genes is known as a major locus controlling immune responses and autoimmune diseases, including arthritis. Here, we split a congenic fragment derived from the NOD mouse (Cia9) to study its effect on immune response and arthritis in mice. We fo...

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Veröffentlicht in:	European journal of immunology 2021-03, Vol.51 (3), p.682-693
Hauptverfasser:	Vaartjes, Daniëlle, Klaczkowska, Dorota, Cragg, Mark S, Nandakumar, Kutty Selva, Bäckdahl, Liselotte, Holmdahl, Rikard
Format:	Artikel
Sprache:	eng
Schlagworte:	Alleles Animals Arthritis Arthritis, Experimental - genetics Autoimmune diseases Autoimmune Diseases - genetics Basic Cell activation Cell Line, Tumor Cells, Cultured Cia9 locus collagen-induced arthritis Disease Models, Animal Fc gamma receptor Fc receptors FcγR2b FcγR3 Gene polymorphism Genetic Predisposition to Disease - genetics Haplotypes Haplotypes - genetics Humans Immune response Immunodeficiencies and autoimmunity Macrophages Mice Mice, Inbred C57BL Mice, Inbred NOD Mice, Knockout Phagocytosis Polymorphism, Genetic - genetics Receptors, IgG - genetics Recombination
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