A comprehensive library of human transcription factors for cell fate engineering

Human pluripotent stem cells (hPSCs) offer an unprecedented opportunity to model diverse cell types and tissues. To enable systematic exploration of the programming landscape mediated by transcription factors (TFs), we present the Human TFome, a comprehensive library containing 1,564 TF genes and 1,...

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Veröffentlicht in:	Nature biotechnology 2021-04, Vol.39 (4), p.510-519
Hauptverfasser:	Ng, Alex H. M., Khoshakhlagh, Parastoo, Rojo Arias, Jesus Eduardo, Pasquini, Giovanni, Wang, Kai, Swiersy, Anka, Shipman, Seth L., Appleton, Evan, Kiaee, Kiavash, Kohman, Richie E., Vernet, Andyna, Dysart, Matthew, Leeper, Kathleen, Saylor, Wren, Huang, Jeremy Y., Graveline, Amanda, Taipale, Jussi, Hill, David E., Vidal, Marc, Melero-Martin, Juan M., Busskamp, Volker, Church, George M.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/532/1360 631/61/2035 631/61/2320 Agriculture Alternative Splicing Bioinformatics Biology Biomechanics Biomedical and Life Sciences Biomedical engineering Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell Differentiation Cell Engineering Cell fate Cells, Cultured Cellular Reprogramming Techniques - methods Coculture Techniques Combinatorial analysis Comparative analysis Developmental biology Differentiation Fibroblasts Genes Genetic aspects Genomic libraries Humans Identification and classification Isoforms Libraries Life Sciences Methods Myelination Oligodendrocytes Oligodendroglia - cytology Oligodendroglia - metabolism Organoids Parallel programming Pluripotency Pluripotent Stem Cells - cytology Pluripotent Stem Cells - metabolism Resource Screening Stem cells Systems Biology Transcription factors Transcription Factors - genetics
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