Infectious RNA vaccine protects mice against chikungunya virus infection

We describe a novel vaccine platform that can generate protective immunity to chikungunya virus (CHIKV) in C57BL/6J mice after a single immunization by employing an infectious RNA (iRNA), which upon introduction into a host cell launches an infectious attenuated virus. We and others have previously...

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Veröffentlicht in:	Scientific reports 2020-12, Vol.10 (1), p.21076-21076, Article 21076
Hauptverfasser:	Szurgot, Inga, Ljungberg, Karl, Kümmerer, Beate M., Liljeström, Peter
Format:	Artikel
Sprache:	eng
Schlagworte:	631/250/590/2293 631/326/596/1282 Animals Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Chikungunya Fever - immunology Chikungunya Fever - prevention & control Chikungunya Fever - virology Chikungunya virus Chikungunya virus - genetics Chikungunya virus - immunology Chikungunya virus - pathogenicity DNA vaccines Female Gene deletion Humanities and Social Sciences Immunization Immunogenicity, Vaccine Injections, Intramuscular Mice Mice, Inbred C57BL mRNA Vaccines multidisciplinary Mutation Nucleotides Protected animals Ribonucleic acid RNA Science Science (multidisciplinary) Transfection Vaccines Vaccines, Attenuated - administration & dosage Vaccines, Attenuated - genetics Vaccines, Attenuated - immunology Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - genetics Vaccines, Synthetic - immunology Vector-borne diseases Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Viremia Viruses
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