Reading the room: iNKT cells influence B cell responses
Rapid immune responses regulated by invariant Natural Killer T (iNKT) cells bridge the gap between innate and adaptive responses to pathogens, while also providing key regulation to maintain immune homeostasis. iNKT immune protection and immune regulation are both mediated through interactions with...
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| Veröffentlicht in: | Molecular immunology 2021-02, Vol.130, p.49-54 |
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| container_title | Molecular immunology |
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| creator | Leadbetter, Elizabeth A. Karlsson, Mikael C.I. |
| description | Rapid immune responses regulated by invariant Natural Killer T (iNKT) cells bridge the gap between innate and adaptive responses to pathogens, while also providing key regulation to maintain immune homeostasis. iNKT immune protection and immune regulation are both mediated through interactions with innate and adaptive B cell populations that express CD1d. Recent studies have expanded our understanding of the position of iNKT cells at the fulcrum between regulating inflammatory and autoreactive B cells. Environmental signals influence iNKT cells to set the tone for subsequent adaptive responses, ranging from maintaining homeostasis as an iNKT regulatory cell (iNKTreg) or supporting pathogen-specific effector B cells as an iNKT follicular helper (iNKTFH). Here we review recent advances in iNKT and B cell cooperation during autoimmunity and sterile inflammation. Understanding the nature of the interactions between iNKT and B cells will enable the development of clinical interventions to strategically target regulatory iNKT and B cell populations or inflammatory ones, across a range of indications. |
| doi_str_mv | 10.1016/j.molimm.2020.12.005 |
| format | Article |
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Recent studies have expanded our understanding of the position of iNKT cells at the fulcrum between regulating inflammatory and autoreactive B cells. Environmental signals influence iNKT cells to set the tone for subsequent adaptive responses, ranging from maintaining homeostasis as an iNKT regulatory cell (iNKTreg) or supporting pathogen-specific effector B cells as an iNKT follicular helper (iNKTFH). Here we review recent advances in iNKT and B cell cooperation during autoimmunity and sterile inflammation. 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Recent studies have expanded our understanding of the position of iNKT cells at the fulcrum between regulating inflammatory and autoreactive B cells. Environmental signals influence iNKT cells to set the tone for subsequent adaptive responses, ranging from maintaining homeostasis as an iNKT regulatory cell (iNKTreg) or supporting pathogen-specific effector B cells as an iNKT follicular helper (iNKTFH). Here we review recent advances in iNKT and B cell cooperation during autoimmunity and sterile inflammation. Understanding the nature of the interactions between iNKT and B cells will enable the development of clinical interventions to strategically target regulatory iNKT and B cell populations or inflammatory ones, across a range of indications.</description><subject>Animals</subject><subject>Autoimmunity - immunology</subject><subject>B-Lymphocytes - immunology</subject><subject>Breg cells</subject><subject>FHiNKTreg</subject><subject>Humans</subject><subject>Humoral immunity</subject><subject>Immunity, Innate - physiology</subject><subject>Inflammation - etiology</subject><subject>Inflammation - immunology</subject><subject>iNKT</subject><subject>invariant Natural Killer T cells (iNKT)</subject><subject>Lymphocyte Activation - immunology</subject><subject>Marginal zone B cells</subject><subject>Natural Killer T-Cells - physiology</subject><issn>0161-5890</issn><issn>1872-9142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kN1OAjEQhRujEUTfwJh9gcVpu9vuemGixL9oNDF43SztLBT3h7SA8e0tgig3XrU5c86ZyUfIKYU-BSrOp_26rWxd9xmwILE-QLpHujSTLM5pwvZJN9honGY5dMiR91MAECDSQ9LhnAvgUnSJfMXC2GYczScYubatLyL7_DiMNFaVj2xTVgtsNEbX30rk0M_axqM_JgdlUXk82bw98nZ7Mxzcx08vdw-Dq6dYp0Dnscm4SBA4w5xKgJwZnlCQJi8pz0W4gpqi0KkQRohRmXKRyRDkRaZNKUcs5T0Sr3v9B84WIzVzti7cp2oLqzbSe_ihSkQqKA3-y7U_TGo0Gpu5K6qd2O6ksRM1bpdK5kwygFCQrAu0a713WG6zFNQKvJqqNXi1Aq8oUwF8iJ393bsN_ZD-PQwDraVFp7y2K7TGOtRzZVr7_4YvTOiWJQ</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Leadbetter, Elizabeth A.</creator><creator>Karlsson, Mikael C.I.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-4994-6684</orcidid></search><sort><creationdate>20210201</creationdate><title>Reading the room: iNKT cells influence B cell responses</title><author>Leadbetter, Elizabeth A. ; Karlsson, Mikael C.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c501t-d8364e032e9170092d34107d9f13963361daac566d66bf53687c503a8cdf7b253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Animals</topic><topic>Autoimmunity - immunology</topic><topic>B-Lymphocytes - immunology</topic><topic>Breg cells</topic><topic>FHiNKTreg</topic><topic>Humans</topic><topic>Humoral immunity</topic><topic>Immunity, Innate - physiology</topic><topic>Inflammation - etiology</topic><topic>Inflammation - immunology</topic><topic>iNKT</topic><topic>invariant Natural Killer T cells (iNKT)</topic><topic>Lymphocyte Activation - immunology</topic><topic>Marginal zone B cells</topic><topic>Natural Killer T-Cells - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leadbetter, Elizabeth A.</creatorcontrib><creatorcontrib>Karlsson, Mikael C.I.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Molecular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leadbetter, Elizabeth A.</au><au>Karlsson, Mikael C.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reading the room: iNKT cells influence B cell responses</atitle><jtitle>Molecular immunology</jtitle><addtitle>Mol Immunol</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>130</volume><spage>49</spage><epage>54</epage><pages>49-54</pages><issn>0161-5890</issn><eissn>1872-9142</eissn><abstract>Rapid immune responses regulated by invariant Natural Killer T (iNKT) cells bridge the gap between innate and adaptive responses to pathogens, while also providing key regulation to maintain immune homeostasis. iNKT immune protection and immune regulation are both mediated through interactions with innate and adaptive B cell populations that express CD1d. 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| ispartof | Molecular immunology, 2021-02, Vol.130, p.49-54 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; SWEPUB Freely available online |
| subjects | Animals Autoimmunity - immunology B-Lymphocytes - immunology Breg cells FHiNKTreg Humans Humoral immunity Immunity, Innate - physiology Inflammation - etiology Inflammation - immunology iNKT invariant Natural Killer T cells (iNKT) Lymphocyte Activation - immunology Marginal zone B cells Natural Killer T-Cells - physiology |
| title | Reading the room: iNKT cells influence B cell responses |
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