Subcellular Distribution of p53 by the p53-Responsive lncRNA NBAT1 Determines Chemotherapeutic Response in Neuroblastoma

Neuroblastoma has a low mutation rate for the gene. Alternative ways of p53 inactivation have been proposed in neuroblastoma, such as abnormal cytoplasmic accumulation of wild-type p53. However, mechanisms leading to p53 inactivation via cytoplasmic accumulation are not well investigated. Here we sh...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-03, Vol.81 (6), p.1457-1471
Hauptverfasser:	Mitra, Sanhita, Muralidharan, Somsundar Veppil, Di Marco, Mirco, Juvvuna, Prasanna Kumar, Kosalai, Subazini Thankaswamy, Reischl, Silke, Jachimowicz, Daniel, Subhash, Santhilal, Raimondi, Ivan, Kurian, Leo, Huarte, Maite, Kogner, Per, Fischer, Matthias, Johnsen, John Inge, Mondal, Tanmoy, Kanduri, Chandrasekhar
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Apoptosis Cancer and Oncology Cancer och onkologi Cell and Molecular Biology Cell Fractionation Cell Line, Tumor Cell Nucleus - genetics Cell Nucleus - metabolism Cell- och molekylärbiologi Cytoplasm - genetics Cytoplasm - metabolism DNA Damage - drug effects Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Exportin 1 Protein Farmaceutisk vetenskap Female Gene Expression Regulation, Neoplastic - drug effects Gene Knockdown Techniques Humans Karyopherins - antagonists & inhibitors Karyopherins - metabolism Läkemedelskemi Male Medicin och hälsovetenskap Medicinal Chemistry Mice Mitochondria - genetics Mitochondria - metabolism Neuroblastoma - drug therapy Neuroblastoma - genetics Neuroblastoma - pathology Neuroblastoma - surgery Pharmaceutical Sciences Proto-Oncogene Proteins c-mdm2 - antagonists & inhibitors Proto-Oncogene Proteins c-mdm2 - metabolism Receptors, Cytoplasmic and Nuclear - antagonists & inhibitors Receptors, Cytoplasmic and Nuclear - metabolism RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Xenograft Model Antitumor Assays
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