A FabG inhibitor targeting an allosteric binding site inhibits several orthologs from Gram-negative ESKAPE pathogens

[Display omitted] •FabG from the bacterial fatty acid biosynthesis (FAS-II) system is a potential target for antibiotics.•Inhibitors were identified by screening FabG proteins from S. typhimurium and to A. baumannii.•The most effective compound inhibits FabG orthologs from several pathogenic bacteri...

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Veröffentlicht in:Bioorganic & medicinal chemistry 2021-01, Vol.30, p.115898-115898, Article 115898
Hauptverfasser: Vella, Peter, Rudraraju, Reshma Srilakshmi, Lundbäck, Thomas, Axelsson, Hanna, Almqvist, Helena, Vallin, Michaela, Schneider, Gunter, Schnell, Robert
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Sprache:eng
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