Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1

Cyclin A2 is a key regulator of the cell cycle, implicated both in DNA replication and mitotic entry. Cyclin A2 participates in feedback loops that activate mitotic kinases in G2 phase, but why active Cyclin A2-CDK2 during the S phase does not trigger mitotic kinase activation remains unclear. Here,...

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Veröffentlicht in:	LIFE SCIENCE ALLIANCE 2021-03, Vol.4 (3), p.e202000980
Hauptverfasser:	Silva Cascales, Helena, Burdova, Kamila, Middleton, Anna, Kuzin, Vladislav, Müllers, Erik, Stoy, Henriette, Baranello, Laura, Macurek, Libor, Lindqvist, Arne
Format:	Artikel
Sprache:	eng
Schlagworte:	CDC2 Protein Kinase - deficiency CDC2 Protein Kinase - genetics Cell Cycle Proteins - metabolism Cell Nucleus - metabolism Chromatin - metabolism Cyclin A2 - genetics Cyclin A2 - metabolism Cyclin-Dependent Kinase 2 - deficiency Cyclin-Dependent Kinase 2 - genetics Cytoplasm - metabolism DNA Damage - genetics Enzyme Activation - genetics G2 Phase - genetics HeLa Cells Humans Mitosis - genetics Phosphorylation - genetics Polo-Like Kinase 1 Protein Binding Protein Serine-Threonine Kinases - metabolism Proto-Oncogene Proteins - metabolism S Phase - genetics Signal Transduction - genetics Transfection
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