Phosphodiesterase 4A confers resistance to PGE2-mediated suppression in CD25+/CD54+ NK cells

Inadequate persistence of tumor-infiltrating natural killer (NK) cells is associated with poor prognosis in cancer patients. The solid tumor microenvironment is characterized by the presence of immunosuppressive factors, including prostaglandin E2 (PGE2), that limit NK cell persistence. Here, we inv...

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Veröffentlicht in:	EMBO reports 2021-03, Vol.22 (3), p.e51329-n/a
Hauptverfasser:	Chen, Ziqing, Yang, Ying, Neo, Shi Y, Shi, Hao, Chen, Yi, Wagner, Arnika K, Larsson, Karin, Tong, Le, Jakobsson, Per-Johan, Alici, Evren, Wu, Jing, Cao, Yihai, Wang, Kai, Liu, Lisa L, Mao, Yumeng, Sarhan, Dhifaf, Lundqvist, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Cancer CD25 antigen Cell therapy Cytokines EMBO03 EMBO19 EMBO37 Genomes Lung cancer Medical prognosis Natural killer cells Phosphodiesterase Prostaglandin E Prostaglandin E2 Signatures Solid tumors Spheroids Survival TOR protein Tumor microenvironment Tumors Xenografts Xenotransplantation Zebrafish
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