One-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparison
Mortality in the first postoperative year represents an accurate reflection of the perioperative risk after colorectal cancer surgery. This research compares one-year mortality after surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment...
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| Veröffentlicht in: | European journal of surgical oncology 2021-07, Vol.47 (7), p.1651-1660 |
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| creator | Bahadoer, Renu R. Bastiaannet, Esther Claassen, Yvette H.M. van der Mark, Marianne van Eycken, Elizabeth Verbeeck, Julie Guren, Marianne G. Kørner, Hartwig Martling, Anna Johansson, Robert van de Velde, Cornelis J.H. Dekker, Jan Willem T. |
| description | Mortality in the first postoperative year represents an accurate reflection of the perioperative risk after colorectal cancer surgery. This research compares one-year mortality after surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment strategies.
Population-based data of all patients diagnosed and treated surgically for stage I-III primary colorectal cancer from 2007 to 2016, were collected from Belgium, the Netherlands, Norway, and Sweden. Stratified for age-category and stage, treatment was evaluated, and 30-day, one-year and one-year excess mortality were calculated for colon and rectal cancer separately. Results were evaluated over two-year time periods.
Data of 206,024 patients were analysed. Postoperative 30-day and one-year mortality reduced significantly over time in all countries and age-categories. Within the oldest age category, in 2015–2016, one-year excess mortality varied from 9% in Belgium to 4% in Sweden for colon cancer and, from 9% in Belgium to 3% in the other countries for rectal cancer. With increasing age, patients were less likely to receive additional therapy besides surgery. In Belgium, colon cancer patients were more often treated with adjuvant chemotherapy (p |
| doi_str_mv | 10.1016/j.ejso.2021.01.011 |
| format | Article |
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Population-based data of all patients diagnosed and treated surgically for stage I-III primary colorectal cancer from 2007 to 2016, were collected from Belgium, the Netherlands, Norway, and Sweden. Stratified for age-category and stage, treatment was evaluated, and 30-day, one-year and one-year excess mortality were calculated for colon and rectal cancer separately. Results were evaluated over two-year time periods.
Data of 206,024 patients were analysed. Postoperative 30-day and one-year mortality reduced significantly over time in all countries and age-categories. Within the oldest age category, in 2015–2016, one-year excess mortality varied from 9% in Belgium to 4% in Sweden for colon cancer and, from 9% in Belgium to 3% in the other countries for rectal cancer. With increasing age, patients were less likely to receive additional therapy besides surgery. In Belgium, colon cancer patients were more often treated with adjuvant chemotherapy (p < 0.001). For neoadjuvant treatment of rectal cancer, patients in Belgium and Norway were mostly treated with chemoradiotherapy. In the Netherlands and Sweden, radiotherapy alone was preferred (p < 0.001).
Despite improvement over time in all countries and age-categories, substantial variation exists in one-year postoperative mortality. Differences in one-year excess postoperative mortality could be due to differences in treatment strategies, highlighting the consequences of under- and over-treatment on cancer survival.
•One-year excess mortality reduced in Belgium, the Netherlands, Norway and Sweden•There is variation in one-year postoperative mortality between these countries•Differences between these countries are possibly due to differences in treatment•It is important to be aware of the trade-offs between under- and overtreatment</description><identifier>ISSN: 0748-7983</identifier><identifier>ISSN: 1532-2157</identifier><identifier>EISSN: 1532-2157</identifier><identifier>DOI: 10.1016/j.ejso.2021.01.011</identifier><identifier>PMID: 33518367</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Colorectal neoplasms ; epidemiology ; Internationality ; Medicin och hälsovetenskap ; Mortality ; Treatment</subject><ispartof>European journal of surgical oncology, 2021-07, Vol.47 (7), p.1651-1660</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-59610b3a66af45c2e2cfe349e7ab613516a14b35b164690d74764cb6a20f2c913</citedby><cites>FETCH-LOGICAL-c526t-59610b3a66af45c2e2cfe349e7ab613516a14b35b164690d74764cb6a20f2c913</cites><orcidid>0000-0002-6321-6453</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ejso.2021.01.011$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33518367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-180454$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:146942272$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Bahadoer, Renu R.</creatorcontrib><creatorcontrib>Bastiaannet, Esther</creatorcontrib><creatorcontrib>Claassen, Yvette H.M.</creatorcontrib><creatorcontrib>van der Mark, Marianne</creatorcontrib><creatorcontrib>van Eycken, Elizabeth</creatorcontrib><creatorcontrib>Verbeeck, Julie</creatorcontrib><creatorcontrib>Guren, Marianne G.</creatorcontrib><creatorcontrib>Kørner, Hartwig</creatorcontrib><creatorcontrib>Martling, Anna</creatorcontrib><creatorcontrib>Johansson, Robert</creatorcontrib><creatorcontrib>van de Velde, Cornelis J.H.</creatorcontrib><creatorcontrib>Dekker, Jan Willem T.</creatorcontrib><title>One-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparison</title><title>European journal of surgical oncology</title><addtitle>Eur J Surg Oncol</addtitle><description>Mortality in the first postoperative year represents an accurate reflection of the perioperative risk after colorectal cancer surgery. This research compares one-year mortality after surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment strategies.
Population-based data of all patients diagnosed and treated surgically for stage I-III primary colorectal cancer from 2007 to 2016, were collected from Belgium, the Netherlands, Norway, and Sweden. Stratified for age-category and stage, treatment was evaluated, and 30-day, one-year and one-year excess mortality were calculated for colon and rectal cancer separately. Results were evaluated over two-year time periods.
Data of 206,024 patients were analysed. Postoperative 30-day and one-year mortality reduced significantly over time in all countries and age-categories. Within the oldest age category, in 2015–2016, one-year excess mortality varied from 9% in Belgium to 4% in Sweden for colon cancer and, from 9% in Belgium to 3% in the other countries for rectal cancer. With increasing age, patients were less likely to receive additional therapy besides surgery. In Belgium, colon cancer patients were more often treated with adjuvant chemotherapy (p < 0.001). For neoadjuvant treatment of rectal cancer, patients in Belgium and Norway were mostly treated with chemoradiotherapy. In the Netherlands and Sweden, radiotherapy alone was preferred (p < 0.001).
Despite improvement over time in all countries and age-categories, substantial variation exists in one-year postoperative mortality. Differences in one-year excess postoperative mortality could be due to differences in treatment strategies, highlighting the consequences of under- and over-treatment on cancer survival.
•One-year excess mortality reduced in Belgium, the Netherlands, Norway and Sweden•There is variation in one-year postoperative mortality between these countries•Differences between these countries are possibly due to differences in treatment•It is important to be aware of the trade-offs between under- and overtreatment</description><subject>Colorectal neoplasms</subject><subject>epidemiology</subject><subject>Internationality</subject><subject>Medicin och hälsovetenskap</subject><subject>Mortality</subject><subject>Treatment</subject><issn>0748-7983</issn><issn>1532-2157</issn><issn>1532-2157</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>D8T</sourceid><recordid>eNp9kk1r3DAQhkVpaDZp_0APRcdevNWXJbv0smw3bSAQKE2vQpbHqba25Up204X--Mp4k5wSGBgxeuYdhnkRekvJmhIqP-zXsI9-zQijazIHfYFWNOcsYzRXL9GKKFFkqiz4KTqLcU8IKbkqX6FTznNacKlW6N91D9kBTMDw10KMuPNhNK0bD9j0NR4DmLGDfsSux3EKt86atj0sdajxYEaXfiO-c-NPbH3rA9jUj63pLYSPeIN3N992223KU_ADmD5R3WCCi75_jU4a00Z4c8zn6OZi9337Nbu6_nK53VxlNmdyzPJSUlJxI6VpRG4ZMNsAFyUoU0maVpGGiornFZVClqRWQklhK2kYaZgtKT9H2aIb72CYKj0E15lw0N44fSz9Si_QQgrFSOLLJ_kh-Pqx6b6RpsGCMcWenfXZ_dhoH2711E2aFkTkIvHvFz4J_54gjrpz0ULbmh78FDUThWCCcDKjbEFt8DEGaB7EKdGzI_Rez47QsyM0mWPe_d1Rf6o6qB9a7i2QgE8LAOkCfxwEHW26qYXazbfUtXfP6f8HSwnJxA</recordid><startdate>20210701</startdate><enddate>20210701</enddate><creator>Bahadoer, Renu R.</creator><creator>Bastiaannet, Esther</creator><creator>Claassen, Yvette H.M.</creator><creator>van der Mark, Marianne</creator><creator>van Eycken, Elizabeth</creator><creator>Verbeeck, Julie</creator><creator>Guren, Marianne G.</creator><creator>Kørner, Hartwig</creator><creator>Martling, Anna</creator><creator>Johansson, Robert</creator><creator>van de Velde, Cornelis J.H.</creator><creator>Dekker, Jan Willem T.</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>ADHXS</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>D93</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-6321-6453</orcidid></search><sort><creationdate>20210701</creationdate><title>One-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparison</title><author>Bahadoer, Renu R. ; 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This research compares one-year mortality after surgery divided into three age-categories (18-64, 65-74, ≥75 years), focusing on time trends and comparing treatment strategies.
Population-based data of all patients diagnosed and treated surgically for stage I-III primary colorectal cancer from 2007 to 2016, were collected from Belgium, the Netherlands, Norway, and Sweden. Stratified for age-category and stage, treatment was evaluated, and 30-day, one-year and one-year excess mortality were calculated for colon and rectal cancer separately. Results were evaluated over two-year time periods.
Data of 206,024 patients were analysed. Postoperative 30-day and one-year mortality reduced significantly over time in all countries and age-categories. Within the oldest age category, in 2015–2016, one-year excess mortality varied from 9% in Belgium to 4% in Sweden for colon cancer and, from 9% in Belgium to 3% in the other countries for rectal cancer. With increasing age, patients were less likely to receive additional therapy besides surgery. In Belgium, colon cancer patients were more often treated with adjuvant chemotherapy (p < 0.001). For neoadjuvant treatment of rectal cancer, patients in Belgium and Norway were mostly treated with chemoradiotherapy. In the Netherlands and Sweden, radiotherapy alone was preferred (p < 0.001).
Despite improvement over time in all countries and age-categories, substantial variation exists in one-year postoperative mortality. Differences in one-year excess postoperative mortality could be due to differences in treatment strategies, highlighting the consequences of under- and over-treatment on cancer survival.
•One-year excess mortality reduced in Belgium, the Netherlands, Norway and Sweden•There is variation in one-year postoperative mortality between these countries•Differences between these countries are possibly due to differences in treatment•It is important to be aware of the trade-offs between under- and overtreatment</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>33518367</pmid><doi>10.1016/j.ejso.2021.01.011</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-6321-6453</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0748-7983 |
| ispartof | European journal of surgical oncology, 2021-07, Vol.47 (7), p.1651-1660 |
| issn | 0748-7983 1532-2157 1532-2157 |
| language | eng |
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| source | SWEPUB Freely available online; Access via ScienceDirect (Elsevier) |
| subjects | Colorectal neoplasms epidemiology Internationality Medicin och hälsovetenskap Mortality Treatment |
| title | One-year excess mortality and treatment in surgically treated patients with colorectal cancer: A EURECCA European comparison |
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