Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery
Abstract Context Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown. Objective To investigate how SAT mitochondria change following diet-induced and bariatric surgery–indu...
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| Veröffentlicht in: | The journal of clinical endocrinology and metabolism 2021-05, Vol.106 (5), p.1312-1324 |
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| creator | van der Kolk, Birgitta W Muniandy, Maheswary Kaminska, Dorota Alvarez, Marcus Ko, Arthur Miao, Zong Valsesia, Armand Langin, Dominique Vaittinen, Maija Pääkkönen, Mirva Jokinen, Riikka Kaye, Sanna Heinonen, Sini Virtanen, Kirsi A Andersson, Daniel P Männistö, Ville Saris, Wim H Astrup, Arne Rydén, Mikael Blaak, Ellen E Pajukanta, Päivi Pihlajamäki, Jussi Pietiläinen, Kirsi H |
| description | Abstract
Context
Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown.
Objective
To investigate how SAT mitochondria change following diet-induced and bariatric surgery–induced weight-loss interventions in 4 independent weight-loss studies.
Methods
The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up.
Results
Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: −8.7 following LCD, −4.4 following weight maintenance; CRYO: IPA z-score: −5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001).
Conclusions
Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success. |
| doi_str_mv | 10.1210/clinem/dgab072 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_464462</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A702375122</galeid><oup_id>10.1210/clinem/dgab072</oup_id><sourcerecordid>A702375122</sourcerecordid><originalsourceid>FETCH-LOGICAL-c591t-4dc7b8dc940844b7344984f1fc797f0fe32c409ce5e3b6d4d16bc30583d03e863</originalsourceid><addsrcrecordid>eNqFUk1v1DAQjRCIlsKVI7LEBQ5p_ZU4viAt_ZYWcaAIblZiT7IuWXtrJ1323-Nol5ZWlZAPtmfee555nix7S_AhoQQf6d46WB6Zrm6woM-yfSJ5kQsixfNsH2NKcinoz73sVYzXGBPOC_Yy22OsKDETdD9bn9i2hQBusHWPvtjB64V3Jky3c3CATn-vAsRovUPWoZmxKx8BXdkYR0Bnvu_92roO_QDbLQY09zGiS2dGDQY1G3RiYUA-oM91UhyC1ejbGDoIm9fZi7buI7zZ7QfZ97PTq-OLfP71_PJ4Ns91IcmQc6NFUxktOa44bwTjXFa8Ja0WUrS4BUY1x1JDAawpDTekbDTDRcUMZlCV7CDLt7pxDauxUatgl3XYKF9btQv9SidQvOS8pAn_aYtPmSUYnYwJdf-A9jDj7EJ1_lZVuGS0JEng41Zg8Yh2MZurKYZ5xaQo8O2E_bB7LPibEeKgljZq6PvagR-jorwSgqe6cIK-fwS99mNwyTpFZVGSsigqeY_q6h6Uda1PNepJVM0EpkwUhE49Hj6BSsvA0mrvoLUp_hRBh_S_Adq7xghW0xiq7Riq3Rgmwrt_XbyD_527e5f8uPqf2B_B6uiu</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2956165589</pqid></control><display><type>article</type><title>Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery</title><source>Oxford University Press Journals All Titles (1996-Current)</source><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><creator>van der Kolk, Birgitta W ; Muniandy, Maheswary ; Kaminska, Dorota ; Alvarez, Marcus ; Ko, Arthur ; Miao, Zong ; Valsesia, Armand ; Langin, Dominique ; Vaittinen, Maija ; Pääkkönen, Mirva ; Jokinen, Riikka ; Kaye, Sanna ; Heinonen, Sini ; Virtanen, Kirsi A ; Andersson, Daniel P ; Männistö, Ville ; Saris, Wim H ; Astrup, Arne ; Rydén, Mikael ; Blaak, Ellen E ; Pajukanta, Päivi ; Pihlajamäki, Jussi ; Pietiläinen, Kirsi H</creator><creatorcontrib>van der Kolk, Birgitta W ; Muniandy, Maheswary ; Kaminska, Dorota ; Alvarez, Marcus ; Ko, Arthur ; Miao, Zong ; Valsesia, Armand ; Langin, Dominique ; Vaittinen, Maija ; Pääkkönen, Mirva ; Jokinen, Riikka ; Kaye, Sanna ; Heinonen, Sini ; Virtanen, Kirsi A ; Andersson, Daniel P ; Männistö, Ville ; Saris, Wim H ; Astrup, Arne ; Rydén, Mikael ; Blaak, Ellen E ; Pajukanta, Päivi ; Pihlajamäki, Jussi ; Pietiläinen, Kirsi H</creatorcontrib><description>Abstract
Context
Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown.
Objective
To investigate how SAT mitochondria change following diet-induced and bariatric surgery–induced weight-loss interventions in 4 independent weight-loss studies.
Methods
The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up.
Results
Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: −8.7 following LCD, −4.4 following weight maintenance; CRYO: IPA z-score: −5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001).
Conclusions
Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.</description><identifier>ISSN: 0021-972X</identifier><identifier>EISSN: 1945-7197</identifier><identifier>DOI: 10.1210/clinem/dgab072</identifier><identifier>PMID: 33560372</identifier><language>eng</language><publisher>US: Oxford University Press</publisher><subject>Adipose tissue ; Adipose Tissue - metabolism ; Adipose tissues ; Adult ; Analysis ; Bariatric Surgery ; Body fat ; Body weight loss ; Cardiology and cardiovascular system ; Clinical s ; Diet ; Diet, Reducing ; Energy balance ; Female ; Gastric bypass ; Gastrointestinal surgery ; Gene Expression ; Gene Expression Profiling ; Genes ; Genes, Mitochondrial - genetics ; Health maintenance organizations ; Homeostasis ; Human health and pathology ; Humans ; Hypocaloric diet ; Life Sciences ; Liquid crystal displays ; Male ; Metabolic Networks and Pathways - genetics ; Middle Aged ; Mitochondria ; Mitochondria - genetics ; Mitochondria - metabolism ; Nutrient deficiency ; Obesity ; Obesity, Morbid - diet therapy ; Obesity, Morbid - genetics ; Obesity, Morbid - surgery ; Oxidative phosphorylation ; Phosphorylation ; Proteomics ; Retrospective Studies ; RNA ; Standard scores ; Surgery ; Type 2 diabetes ; Weight Loss - genetics ; Weight Loss - physiology ; Weight loss maintenance ; Weight Reduction Programs</subject><ispartof>The journal of clinical endocrinology and metabolism, 2021-05, Vol.106 (5), p.1312-1324</ispartof><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. 2021</rights><rights>The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society.</rights><rights>COPYRIGHT 2021 Oxford University Press</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c591t-4dc7b8dc940844b7344984f1fc797f0fe32c409ce5e3b6d4d16bc30583d03e863</citedby><cites>FETCH-LOGICAL-c591t-4dc7b8dc940844b7344984f1fc797f0fe32c409ce5e3b6d4d16bc30583d03e863</cites><orcidid>0000-0003-0985-0047 ; 0000-0002-6241-6859 ; 0000-0002-2669-7825 ; 0000-0001-8608-541X ; 0000-0002-6183-4565</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33560372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://ut3-toulouseinp.hal.science/hal-04839750$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:146871538$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>van der Kolk, Birgitta W</creatorcontrib><creatorcontrib>Muniandy, Maheswary</creatorcontrib><creatorcontrib>Kaminska, Dorota</creatorcontrib><creatorcontrib>Alvarez, Marcus</creatorcontrib><creatorcontrib>Ko, Arthur</creatorcontrib><creatorcontrib>Miao, Zong</creatorcontrib><creatorcontrib>Valsesia, Armand</creatorcontrib><creatorcontrib>Langin, Dominique</creatorcontrib><creatorcontrib>Vaittinen, Maija</creatorcontrib><creatorcontrib>Pääkkönen, Mirva</creatorcontrib><creatorcontrib>Jokinen, Riikka</creatorcontrib><creatorcontrib>Kaye, Sanna</creatorcontrib><creatorcontrib>Heinonen, Sini</creatorcontrib><creatorcontrib>Virtanen, Kirsi A</creatorcontrib><creatorcontrib>Andersson, Daniel P</creatorcontrib><creatorcontrib>Männistö, Ville</creatorcontrib><creatorcontrib>Saris, Wim H</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><creatorcontrib>Rydén, Mikael</creatorcontrib><creatorcontrib>Blaak, Ellen E</creatorcontrib><creatorcontrib>Pajukanta, Päivi</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Pietiläinen, Kirsi H</creatorcontrib><title>Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery</title><title>The journal of clinical endocrinology and metabolism</title><addtitle>J Clin Endocrinol Metab</addtitle><description>Abstract
Context
Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown.
Objective
To investigate how SAT mitochondria change following diet-induced and bariatric surgery–induced weight-loss interventions in 4 independent weight-loss studies.
Methods
The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up.
Results
Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: −8.7 following LCD, −4.4 following weight maintenance; CRYO: IPA z-score: −5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001).
Conclusions
Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - metabolism</subject><subject>Adipose tissues</subject><subject>Adult</subject><subject>Analysis</subject><subject>Bariatric Surgery</subject><subject>Body fat</subject><subject>Body weight loss</subject><subject>Cardiology and cardiovascular system</subject><subject>Clinical s</subject><subject>Diet</subject><subject>Diet, Reducing</subject><subject>Energy balance</subject><subject>Female</subject><subject>Gastric bypass</subject><subject>Gastrointestinal surgery</subject><subject>Gene Expression</subject><subject>Gene Expression Profiling</subject><subject>Genes</subject><subject>Genes, Mitochondrial - genetics</subject><subject>Health maintenance organizations</subject><subject>Homeostasis</subject><subject>Human health and pathology</subject><subject>Humans</subject><subject>Hypocaloric diet</subject><subject>Life Sciences</subject><subject>Liquid crystal displays</subject><subject>Male</subject><subject>Metabolic Networks and Pathways - genetics</subject><subject>Middle Aged</subject><subject>Mitochondria</subject><subject>Mitochondria - genetics</subject><subject>Mitochondria - metabolism</subject><subject>Nutrient deficiency</subject><subject>Obesity</subject><subject>Obesity, Morbid - diet therapy</subject><subject>Obesity, Morbid - genetics</subject><subject>Obesity, Morbid - surgery</subject><subject>Oxidative phosphorylation</subject><subject>Phosphorylation</subject><subject>Proteomics</subject><subject>Retrospective Studies</subject><subject>RNA</subject><subject>Standard scores</subject><subject>Surgery</subject><subject>Type 2 diabetes</subject><subject>Weight Loss - genetics</subject><subject>Weight Loss - physiology</subject><subject>Weight loss maintenance</subject><subject>Weight Reduction Programs</subject><issn>0021-972X</issn><issn>1945-7197</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNqFUk1v1DAQjRCIlsKVI7LEBQ5p_ZU4viAt_ZYWcaAIblZiT7IuWXtrJ1323-Nol5ZWlZAPtmfee555nix7S_AhoQQf6d46WB6Zrm6woM-yfSJ5kQsixfNsH2NKcinoz73sVYzXGBPOC_Yy22OsKDETdD9bn9i2hQBusHWPvtjB64V3Jky3c3CATn-vAsRovUPWoZmxKx8BXdkYR0Bnvu_92roO_QDbLQY09zGiS2dGDQY1G3RiYUA-oM91UhyC1ejbGDoIm9fZi7buI7zZ7QfZ97PTq-OLfP71_PJ4Ns91IcmQc6NFUxktOa44bwTjXFa8Ja0WUrS4BUY1x1JDAawpDTekbDTDRcUMZlCV7CDLt7pxDauxUatgl3XYKF9btQv9SidQvOS8pAn_aYtPmSUYnYwJdf-A9jDj7EJ1_lZVuGS0JEng41Zg8Yh2MZurKYZ5xaQo8O2E_bB7LPibEeKgljZq6PvagR-jorwSgqe6cIK-fwS99mNwyTpFZVGSsigqeY_q6h6Uda1PNepJVM0EpkwUhE49Hj6BSsvA0mrvoLUp_hRBh_S_Adq7xghW0xiq7Riq3Rgmwrt_XbyD_527e5f8uPqf2B_B6uiu</recordid><startdate>20210501</startdate><enddate>20210501</enddate><creator>van der Kolk, Birgitta W</creator><creator>Muniandy, Maheswary</creator><creator>Kaminska, Dorota</creator><creator>Alvarez, Marcus</creator><creator>Ko, Arthur</creator><creator>Miao, Zong</creator><creator>Valsesia, Armand</creator><creator>Langin, Dominique</creator><creator>Vaittinen, Maija</creator><creator>Pääkkönen, Mirva</creator><creator>Jokinen, Riikka</creator><creator>Kaye, Sanna</creator><creator>Heinonen, Sini</creator><creator>Virtanen, Kirsi A</creator><creator>Andersson, Daniel P</creator><creator>Männistö, Ville</creator><creator>Saris, Wim H</creator><creator>Astrup, Arne</creator><creator>Rydén, Mikael</creator><creator>Blaak, Ellen E</creator><creator>Pajukanta, Päivi</creator><creator>Pihlajamäki, Jussi</creator><creator>Pietiläinen, Kirsi H</creator><general>Oxford University Press</general><general>Endocrine Society</general><scope>TOX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-0985-0047</orcidid><orcidid>https://orcid.org/0000-0002-6241-6859</orcidid><orcidid>https://orcid.org/0000-0002-2669-7825</orcidid><orcidid>https://orcid.org/0000-0001-8608-541X</orcidid><orcidid>https://orcid.org/0000-0002-6183-4565</orcidid></search><sort><creationdate>20210501</creationdate><title>Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery</title><author>van der Kolk, Birgitta W ; Muniandy, Maheswary ; Kaminska, Dorota ; Alvarez, Marcus ; Ko, Arthur ; Miao, Zong ; Valsesia, Armand ; Langin, Dominique ; Vaittinen, Maija ; Pääkkönen, Mirva ; Jokinen, Riikka ; Kaye, Sanna ; Heinonen, Sini ; Virtanen, Kirsi A ; Andersson, Daniel P ; Männistö, Ville ; Saris, Wim H ; Astrup, Arne ; Rydén, Mikael ; Blaak, Ellen E ; Pajukanta, Päivi ; Pihlajamäki, Jussi ; Pietiläinen, Kirsi H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c591t-4dc7b8dc940844b7344984f1fc797f0fe32c409ce5e3b6d4d16bc30583d03e863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - metabolism</topic><topic>Adipose tissues</topic><topic>Adult</topic><topic>Analysis</topic><topic>Bariatric Surgery</topic><topic>Body fat</topic><topic>Body weight loss</topic><topic>Cardiology and cardiovascular system</topic><topic>Clinical s</topic><topic>Diet</topic><topic>Diet, Reducing</topic><topic>Energy balance</topic><topic>Female</topic><topic>Gastric bypass</topic><topic>Gastrointestinal surgery</topic><topic>Gene Expression</topic><topic>Gene Expression Profiling</topic><topic>Genes</topic><topic>Genes, Mitochondrial - genetics</topic><topic>Health maintenance organizations</topic><topic>Homeostasis</topic><topic>Human health and pathology</topic><topic>Humans</topic><topic>Hypocaloric diet</topic><topic>Life Sciences</topic><topic>Liquid crystal displays</topic><topic>Male</topic><topic>Metabolic Networks and Pathways - genetics</topic><topic>Middle Aged</topic><topic>Mitochondria</topic><topic>Mitochondria - genetics</topic><topic>Mitochondria - metabolism</topic><topic>Nutrient deficiency</topic><topic>Obesity</topic><topic>Obesity, Morbid - diet therapy</topic><topic>Obesity, Morbid - genetics</topic><topic>Obesity, Morbid - surgery</topic><topic>Oxidative phosphorylation</topic><topic>Phosphorylation</topic><topic>Proteomics</topic><topic>Retrospective Studies</topic><topic>RNA</topic><topic>Standard scores</topic><topic>Surgery</topic><topic>Type 2 diabetes</topic><topic>Weight Loss - genetics</topic><topic>Weight Loss - physiology</topic><topic>Weight loss maintenance</topic><topic>Weight Reduction Programs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van der Kolk, Birgitta W</creatorcontrib><creatorcontrib>Muniandy, Maheswary</creatorcontrib><creatorcontrib>Kaminska, Dorota</creatorcontrib><creatorcontrib>Alvarez, Marcus</creatorcontrib><creatorcontrib>Ko, Arthur</creatorcontrib><creatorcontrib>Miao, Zong</creatorcontrib><creatorcontrib>Valsesia, Armand</creatorcontrib><creatorcontrib>Langin, Dominique</creatorcontrib><creatorcontrib>Vaittinen, Maija</creatorcontrib><creatorcontrib>Pääkkönen, Mirva</creatorcontrib><creatorcontrib>Jokinen, Riikka</creatorcontrib><creatorcontrib>Kaye, Sanna</creatorcontrib><creatorcontrib>Heinonen, Sini</creatorcontrib><creatorcontrib>Virtanen, Kirsi A</creatorcontrib><creatorcontrib>Andersson, Daniel P</creatorcontrib><creatorcontrib>Männistö, Ville</creatorcontrib><creatorcontrib>Saris, Wim H</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><creatorcontrib>Rydén, Mikael</creatorcontrib><creatorcontrib>Blaak, Ellen E</creatorcontrib><creatorcontrib>Pajukanta, Päivi</creatorcontrib><creatorcontrib>Pihlajamäki, Jussi</creatorcontrib><creatorcontrib>Pietiläinen, Kirsi H</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>The journal of clinical endocrinology and metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>van der Kolk, Birgitta W</au><au>Muniandy, Maheswary</au><au>Kaminska, Dorota</au><au>Alvarez, Marcus</au><au>Ko, Arthur</au><au>Miao, Zong</au><au>Valsesia, Armand</au><au>Langin, Dominique</au><au>Vaittinen, Maija</au><au>Pääkkönen, Mirva</au><au>Jokinen, Riikka</au><au>Kaye, Sanna</au><au>Heinonen, Sini</au><au>Virtanen, Kirsi A</au><au>Andersson, Daniel P</au><au>Männistö, Ville</au><au>Saris, Wim H</au><au>Astrup, Arne</au><au>Rydén, Mikael</au><au>Blaak, Ellen E</au><au>Pajukanta, Päivi</au><au>Pihlajamäki, Jussi</au><au>Pietiläinen, Kirsi H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery</atitle><jtitle>The journal of clinical endocrinology and metabolism</jtitle><addtitle>J Clin Endocrinol Metab</addtitle><date>2021-05-01</date><risdate>2021</risdate><volume>106</volume><issue>5</issue><spage>1312</spage><epage>1324</epage><pages>1312-1324</pages><issn>0021-972X</issn><eissn>1945-7197</eissn><abstract>Abstract
Context
Mitochondria are essential for cellular energy homeostasis, yet their role in subcutaneous adipose tissue (SAT) during different types of weight-loss interventions remains unknown.
Objective
To investigate how SAT mitochondria change following diet-induced and bariatric surgery–induced weight-loss interventions in 4 independent weight-loss studies.
Methods
The DiOGenes study is a European multicenter dietary intervention with an 8-week low caloric diet (LCD; 800 kcal/d; n = 261) and 6-month weight-maintenance (n = 121) period. The Kuopio Obesity Surgery study (KOBS) is a Roux-en-Y gastric bypass (RYGB) surgery study (n = 172) with a 1-year follow-up. We associated weight-loss percentage with global and 2210 mitochondria-related RNA transcripts in linear regression analysis adjusted for age and sex. We repeated these analyses in 2 studies. The Finnish CRYO study has a 6-week LCD (800-1000 kcal/d; n = 19) and a 10.5-month follow-up. The Swedish DEOSH study is a RYGB surgery study with a 2-year (n = 49) and 5-year (n = 37) follow-up.
Results
Diet-induced weight loss led to a significant transcriptional downregulation of oxidative phosphorylation (DiOGenes; ingenuity pathway analysis [IPA] z-scores: −8.7 following LCD, −4.4 following weight maintenance; CRYO: IPA z-score: −5.6, all P < 0.001), while upregulation followed surgery-induced weight loss (KOBS: IPA z-score: 1.8, P < 0.001; in DEOSH: IPA z-scores: 4.0 following 2 years, 0.0 following 5 years). We confirmed an upregulated oxidative phosphorylation at the proteomics level following surgery (IPA z-score: 3.2, P < 0.001).
Conclusions
Differentially regulated SAT mitochondria-related gene expressions suggest qualitative alterations between weight-loss interventions, providing insights into the potential molecular mechanistic targets for weight-loss success.</abstract><cop>US</cop><pub>Oxford University Press</pub><pmid>33560372</pmid><doi>10.1210/clinem/dgab072</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-0985-0047</orcidid><orcidid>https://orcid.org/0000-0002-6241-6859</orcidid><orcidid>https://orcid.org/0000-0002-2669-7825</orcidid><orcidid>https://orcid.org/0000-0001-8608-541X</orcidid><orcidid>https://orcid.org/0000-0002-6183-4565</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-972X |
| ispartof | The journal of clinical endocrinology and metabolism, 2021-05, Vol.106 (5), p.1312-1324 |
| issn | 0021-972X 1945-7197 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_464462 |
| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adipose tissue Adipose Tissue - metabolism Adipose tissues Adult Analysis Bariatric Surgery Body fat Body weight loss Cardiology and cardiovascular system Clinical s Diet Diet, Reducing Energy balance Female Gastric bypass Gastrointestinal surgery Gene Expression Gene Expression Profiling Genes Genes, Mitochondrial - genetics Health maintenance organizations Homeostasis Human health and pathology Humans Hypocaloric diet Life Sciences Liquid crystal displays Male Metabolic Networks and Pathways - genetics Middle Aged Mitochondria Mitochondria - genetics Mitochondria - metabolism Nutrient deficiency Obesity Obesity, Morbid - diet therapy Obesity, Morbid - genetics Obesity, Morbid - surgery Oxidative phosphorylation Phosphorylation Proteomics Retrospective Studies RNA Standard scores Surgery Type 2 diabetes Weight Loss - genetics Weight Loss - physiology Weight loss maintenance Weight Reduction Programs |
| title | Differential Mitochondrial Gene Expression in Adipose Tissue Following Weight Loss Induced by Diet or Bariatric Surgery |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T17%3A52%3A38IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Differential%20Mitochondrial%20Gene%20Expression%20in%20Adipose%20Tissue%20Following%20Weight%20Loss%20Induced%20by%20Diet%20or%20Bariatric%20Surgery&rft.jtitle=The%20journal%20of%20clinical%20endocrinology%20and%20metabolism&rft.au=van%20der%20Kolk,%20Birgitta%20W&rft.date=2021-05-01&rft.volume=106&rft.issue=5&rft.spage=1312&rft.epage=1324&rft.pages=1312-1324&rft.issn=0021-972X&rft.eissn=1945-7197&rft_id=info:doi/10.1210/clinem/dgab072&rft_dat=%3Cgale_swepu%3EA702375122%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2956165589&rft_id=info:pmid/33560372&rft_galeid=A702375122&rft_oup_id=10.1210/clinem/dgab072&rfr_iscdi=true |