Pfs230 yields higher malaria transmission-blocking vaccine activity than Pfs25 in humans but not mice

BACKGROUNDVaccines that block human-to-mosquito Plasmodium transmission are needed for malaria eradication, and clinical trials have targeted zygote antigen Pfs25 for decades. We reported that a Pfs25 protein-protein conjugate vaccine formulated in alum adjuvant induced serum functional activity in...

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Veröffentlicht in:	The Journal of clinical investigation 2021-04, Vol.131 (7), p.1-9
Hauptverfasser:	Healy, Sara A, Anderson, Charles, Swihart, Bruce J, Mwakingwe, Agnes, Gabriel, Erin E, Decederfelt, Hope, Hobbs, Charlotte V, Rausch, Kelly M, Zhu, Daming, Muratova, Olga, Herrera, Raul, Scaria, Puthupparampil V, MacDonald, Nicholas J, Lambert, Lynn E, Zaidi, Irfan, Coelho, Camila H, Renn, Jonathan P, Wu, Yimin, Narum, David L, Duffy, Patrick E
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antigens Biomedical research Clinical Medicine Clinical trials Control Disease transmission Enzyme-linked immunosorbent assay Experiments Health aspects Immune response Immunogenicity Malaria Membrane proteins Mosquitoes Parasite vaccines Parasites Pharmaceutical research Proteins Vaccines
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