Modified Hypoxia-Inducible Factor Expression in CD8 + T Cells Increases Antitumor Efficacy

Adoptive transfer of antitumor cytotoxic T cells is an emerging form of cancer immunotherapy. A key challenge to expanding the utility of adoptive cell therapies is how to enhance the survival and function of the transferred T cells. Immune-cell survival requires adaptation to different microenviron...

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Veröffentlicht in:	Cancer immunology research 2021-04, Vol.9 (4), p.401-414
Hauptverfasser:	Veliça, Pedro, Cunha, Pedro P, Vojnovic, Nikola, Foskolou, Iosifina Petrina, Bargiela, David, Gojkovic, Milos, Rundqvist, Helene, Johnson, Randall S
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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