Immunomodulatory Agents Combat Multidrug-Resistant Tuberculosis by Improving Antimicrobial Immunity

Abstract Background Multidrug-resistant (MDR) tuberculosis has low treatment success rates, and new treatment strategies are needed. We explored whether treatment with active vitamin D3 (vitD) and phenylbutyrate (PBA) could improve conventional chemotherapy by enhancing immune-mediated eradication o...

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Veröffentlicht in:	The Journal of infectious diseases 2021-07, Vol.224 (2), p.332-344
Hauptverfasser:	Rao Muvva, Jagadeeswara, Ahmed, Sultan, Rekha, Rokeya Sultana, Kalsum, Sadaf, Groenheit, Ramona, Schön, Thomas, Agerberth, Birgitta, Bergman, Peter, Brighenti, Susanna
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotic resistance Antibiotics Antibiotics, Antitubercular - pharmacology Antimicrobial agents Antimicrobial peptides Antimicrobial Peptides - immunology Autophagy Cells, Cultured Chemotherapy Cholecalciferol - pharmacology Confocal microscopy Drug resistance DUOX2 protein Eradication Gene expression Gene silencing Growth inhibition Humans Immune system Immunity Immunomodulating Agents - pharmacology Immunomodulation Immunomodulators Intracellular Isoniazid Isoniazid - pharmacology Macrophages Macrophages - immunology Macrophages - microbiology Major and Brief Reports Multidrug resistance Multidrug resistant organisms Mycobacterium tuberculosis Nitric-oxide synthase Phagocytosis Phenylbutyric acid Rifampin Rifampin - pharmacology RNA-mediated interference Tuberculosis Tuberculosis, Multidrug-Resistant - drug therapy Tuberculosis, Multidrug-Resistant - immunology Vitamin D3
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