Euglycemia Indicates Favorable Motor Outcome in Parkinson's Disease
Background The interplay between glycemic control and Parkinson's disease (PD) has long been recognized but not fully understood. Objectives To investigate the association of glycated hemoglobin (HbA1c) levels with motor and cognitive symptom progression in a prospective PD cohort. Methods Of 2...
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| Veröffentlicht in: | Movement disorders 2021-06, Vol.36 (6), p.1430-1434 |
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| container_title | Movement disorders |
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| creator | Markaki, Ioanna Ntetsika, Theodora Sorjonen, Kimmo Svenningsson, Per |
| description | Background
The interplay between glycemic control and Parkinson's disease (PD) has long been recognized but not fully understood.
Objectives
To investigate the association of glycated hemoglobin (HbA1c) levels with motor and cognitive symptom progression in a prospective PD cohort.
Methods
Of 244 PD patients, 17 had low HbA1c (≤30 mmol/mol), 184 were euglycemic (HbA1c 31–41 mmol/mol), 18 had high HbA1c (HbA1 ≥42 mmol/mol), and 25 had diabetes mellitus (DM). Survival analysis was applied on time until Hoehn and Yahr stage ≥3 (motor outcome) and until mild cognitive impairment.
Results
Low HbA1c (HR 2.7; 95% CI 1.3–6; P = 0.01) as well as high HbA1c (HR 3.6; 95% CI 1.5–8.9; P = 0.005) but not DM were independent predictors of unfavorable motor outcome.
Conclusions
Both high and low HbA1c levels may be associated with motor symptom progression in PD; however, further studies are needed to confirm these findings and increase understanding regarding causality. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society |
| doi_str_mv | 10.1002/mds.28545 |
| format | Article |
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The interplay between glycemic control and Parkinson's disease (PD) has long been recognized but not fully understood.
Objectives
To investigate the association of glycated hemoglobin (HbA1c) levels with motor and cognitive symptom progression in a prospective PD cohort.
Methods
Of 244 PD patients, 17 had low HbA1c (≤30 mmol/mol), 184 were euglycemic (HbA1c 31–41 mmol/mol), 18 had high HbA1c (HbA1 ≥42 mmol/mol), and 25 had diabetes mellitus (DM). Survival analysis was applied on time until Hoehn and Yahr stage ≥3 (motor outcome) and until mild cognitive impairment.
Results
Low HbA1c (HR 2.7; 95% CI 1.3–6; P = 0.01) as well as high HbA1c (HR 3.6; 95% CI 1.5–8.9; P = 0.005) but not DM were independent predictors of unfavorable motor outcome.
Conclusions
Both high and low HbA1c levels may be associated with motor symptom progression in PD; however, further studies are needed to confirm these findings and increase understanding regarding causality. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society</description><identifier>ISSN: 0885-3185</identifier><identifier>EISSN: 1531-8257</identifier><identifier>DOI: 10.1002/mds.28545</identifier><identifier>PMID: 33634916</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>cognition ; Cognitive ability ; Diabetes mellitus ; Glucose ; glycated hemoglobin ; HbA1c ; Hemoglobin ; motor outcome ; Movement disorders ; Neurodegenerative diseases ; Parkinson's disease ; Survival analysis</subject><ispartof>Movement disorders, 2021-06, Vol.36 (6), p.1430-1434</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society</rights><rights>2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3915-4ea6e7f78603745fb1cdfdd57ea60a4dd746d0d849c4fc2e9d3bd4847dd4ee4c3</citedby><cites>FETCH-LOGICAL-c3915-4ea6e7f78603745fb1cdfdd57ea60a4dd746d0d849c4fc2e9d3bd4847dd4ee4c3</cites><orcidid>0000-0002-3101-5155 ; 0000-0003-3328-5746</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmds.28545$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmds.28545$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33634916$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:146018558$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Markaki, Ioanna</creatorcontrib><creatorcontrib>Ntetsika, Theodora</creatorcontrib><creatorcontrib>Sorjonen, Kimmo</creatorcontrib><creatorcontrib>Svenningsson, Per</creatorcontrib><creatorcontrib>BioPark Study Group</creatorcontrib><creatorcontrib>for the BioPark Study Group</creatorcontrib><title>Euglycemia Indicates Favorable Motor Outcome in Parkinson's Disease</title><title>Movement disorders</title><addtitle>Mov Disord</addtitle><description>Background
The interplay between glycemic control and Parkinson's disease (PD) has long been recognized but not fully understood.
Objectives
To investigate the association of glycated hemoglobin (HbA1c) levels with motor and cognitive symptom progression in a prospective PD cohort.
Methods
Of 244 PD patients, 17 had low HbA1c (≤30 mmol/mol), 184 were euglycemic (HbA1c 31–41 mmol/mol), 18 had high HbA1c (HbA1 ≥42 mmol/mol), and 25 had diabetes mellitus (DM). Survival analysis was applied on time until Hoehn and Yahr stage ≥3 (motor outcome) and until mild cognitive impairment.
Results
Low HbA1c (HR 2.7; 95% CI 1.3–6; P = 0.01) as well as high HbA1c (HR 3.6; 95% CI 1.5–8.9; P = 0.005) but not DM were independent predictors of unfavorable motor outcome.
Conclusions
Both high and low HbA1c levels may be associated with motor symptom progression in PD; however, further studies are needed to confirm these findings and increase understanding regarding causality. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society</description><subject>cognition</subject><subject>Cognitive ability</subject><subject>Diabetes mellitus</subject><subject>Glucose</subject><subject>glycated hemoglobin</subject><subject>HbA1c</subject><subject>Hemoglobin</subject><subject>motor outcome</subject><subject>Movement disorders</subject><subject>Neurodegenerative diseases</subject><subject>Parkinson's disease</subject><subject>Survival analysis</subject><issn>0885-3185</issn><issn>1531-8257</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>D8T</sourceid><recordid>eNp10ctKxDAUBuAgio6XhS8gBRfqopo0J70sZbyCoqCuQ5qcSrRtxmSqzNsb7ehCcJVw-PjJyU_ILqPHjNLspDPhOCsFiBUyYYKztMxEsUomtCxFylkpNshmCC-UMiZYvk42OM85VCyfkOn58NwuNHZWJde9sVrNMSQX6t15VbeY3Lq588ndMNeuw8T2yb3yr7YPrj8IyZkNqAJuk7VGtQF3lucWebo4f5xepTd3l9fT05tU84qJFFDlWDRFmVNegGhqpk1jjCjinCowpoDcUFNCpaHRGVaG1wZKKIwBRNB8i6RjbvjA2VDLmbed8gvplJXL0Wu8oYQc4qrRH45-5t3bgGEuOxs0tq3q0Q1BZlABjzCvIt3_Q1_c4Pu4jcwEZKxiBXypo1Fp70Lw2Pw-gVH51YSMTcjvJqLdWyYOdYfmV_58fQQnI_iwLS7-T5K3Zw9j5CewAZJG</recordid><startdate>202106</startdate><enddate>202106</enddate><creator>Markaki, Ioanna</creator><creator>Ntetsika, Theodora</creator><creator>Sorjonen, Kimmo</creator><creator>Svenningsson, Per</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-3101-5155</orcidid><orcidid>https://orcid.org/0000-0003-3328-5746</orcidid></search><sort><creationdate>202106</creationdate><title>Euglycemia Indicates Favorable Motor Outcome in Parkinson's Disease</title><author>Markaki, Ioanna ; Ntetsika, Theodora ; Sorjonen, Kimmo ; Svenningsson, Per</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3915-4ea6e7f78603745fb1cdfdd57ea60a4dd746d0d849c4fc2e9d3bd4847dd4ee4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>cognition</topic><topic>Cognitive ability</topic><topic>Diabetes mellitus</topic><topic>Glucose</topic><topic>glycated hemoglobin</topic><topic>HbA1c</topic><topic>Hemoglobin</topic><topic>motor outcome</topic><topic>Movement disorders</topic><topic>Neurodegenerative diseases</topic><topic>Parkinson's disease</topic><topic>Survival analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markaki, Ioanna</creatorcontrib><creatorcontrib>Ntetsika, Theodora</creatorcontrib><creatorcontrib>Sorjonen, Kimmo</creatorcontrib><creatorcontrib>Svenningsson, Per</creatorcontrib><creatorcontrib>BioPark Study Group</creatorcontrib><creatorcontrib>for the BioPark Study Group</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Movement disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markaki, Ioanna</au><au>Ntetsika, Theodora</au><au>Sorjonen, Kimmo</au><au>Svenningsson, Per</au><aucorp>BioPark Study Group</aucorp><aucorp>for the BioPark Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Euglycemia Indicates Favorable Motor Outcome in Parkinson's Disease</atitle><jtitle>Movement disorders</jtitle><addtitle>Mov Disord</addtitle><date>2021-06</date><risdate>2021</risdate><volume>36</volume><issue>6</issue><spage>1430</spage><epage>1434</epage><pages>1430-1434</pages><issn>0885-3185</issn><eissn>1531-8257</eissn><abstract>Background
The interplay between glycemic control and Parkinson's disease (PD) has long been recognized but not fully understood.
Objectives
To investigate the association of glycated hemoglobin (HbA1c) levels with motor and cognitive symptom progression in a prospective PD cohort.
Methods
Of 244 PD patients, 17 had low HbA1c (≤30 mmol/mol), 184 were euglycemic (HbA1c 31–41 mmol/mol), 18 had high HbA1c (HbA1 ≥42 mmol/mol), and 25 had diabetes mellitus (DM). Survival analysis was applied on time until Hoehn and Yahr stage ≥3 (motor outcome) and until mild cognitive impairment.
Results
Low HbA1c (HR 2.7; 95% CI 1.3–6; P = 0.01) as well as high HbA1c (HR 3.6; 95% CI 1.5–8.9; P = 0.005) but not DM were independent predictors of unfavorable motor outcome.
Conclusions
Both high and low HbA1c levels may be associated with motor symptom progression in PD; however, further studies are needed to confirm these findings and increase understanding regarding causality. © 2021 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>33634916</pmid><doi>10.1002/mds.28545</doi><tpages>31</tpages><orcidid>https://orcid.org/0000-0002-3101-5155</orcidid><orcidid>https://orcid.org/0000-0003-3328-5746</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | cognition Cognitive ability Diabetes mellitus Glucose glycated hemoglobin HbA1c Hemoglobin motor outcome Movement disorders Neurodegenerative diseases Parkinson's disease Survival analysis |
| title | Euglycemia Indicates Favorable Motor Outcome in Parkinson's Disease |
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