The genetic basis of major depression

Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders, its high prevalence, moderate heritability, and strong polygenicity have posed major challenges for gene-mapping in MDD....

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Veröffentlicht in:	Psychological medicine 2021-10, Vol.51 (13), p.2217-2230
Hauptverfasser:	Kendall, K. M., Van Assche, E., Andlauer, T. F. M., Choi, K. W., Luykx, J. J., Schulte, E. C., Lu, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chromosome Mapping Clinical medicine Copy number Depressive Disorder, Major - epidemiology Depressive Disorder, Major - genetics Depressive personality disorders DNA Copy Number Variations - genetics Electronic health records Epidemiology Estimates Etiology Gender differences Gene mapping Genetic diversity Genetic factors Genetic Loci Genetic susceptibility Genome-Wide Association Study Genomics Health risk assessment Heritability Humans International collaboration Invited Review Mapping Mental depression Mental disorders Molecular genetics Multifactorial Inheritance - genetics Phenotype Quantitative genetics Sexes Twins Variants Womens health
Online-Zugang:	Volltext
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