Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk
Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results. Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization anal...
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| Veröffentlicht in: | Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2021-06, Vol.30 (6), p.1275-1278 |
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| creator | Brown, Derek W Lan, Qing Rothman, Nathaniel Pluta, John Almstrup, Kristian Dalgaard, Marlene D Greene, Mark H Grotmol, Tom Loveday, Chey Schwartz, Stephen M Turnbull, Clare Wiklund, Fredrik Kanetsky, Peter A Nathanson, Katherine L McGlynn, Katherine A Machiela, Mitchell J |
| description | Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.
Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.
Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).
Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.
The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk. |
| doi_str_mv | 10.1158/1055-9965.EPI-20-1775 |
| format | Article |
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Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.
Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).
Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.
The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.</description><identifier>ISSN: 1055-9965</identifier><identifier>ISSN: 1538-7755</identifier><identifier>EISSN: 1538-7755</identifier><identifier>DOI: 10.1158/1055-9965.EPI-20-1775</identifier><identifier>PMID: 33737296</identifier><language>eng</language><publisher>United States</publisher><subject>Case-Control Studies ; Genetic Predisposition to Disease ; Humans ; Male ; Medicin och hälsovetenskap ; Mendelian Randomization Analysis ; Neoplasms, Germ Cell and Embryonal - epidemiology ; Neoplasms, Germ Cell and Embryonal - genetics ; Risk Assessment - statistics & numerical data ; Risk Factors ; Telomere - metabolism ; Telomere Homeostasis - genetics ; Testicular Neoplasms - epidemiology ; Testicular Neoplasms - genetics</subject><ispartof>Cancer epidemiology, biomarkers & prevention, 2021-06, Vol.30 (6), p.1275-1278</ispartof><rights>2021 American Association for Cancer Research.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-68bf4044dfcfe4123591ed88e148f363ebca3411c48b806f3280192e58fe505f3</citedby><cites>FETCH-LOGICAL-c499t-68bf4044dfcfe4123591ed88e148f363ebca3411c48b806f3280192e58fe505f3</cites><orcidid>0000-0001-7499-8502 ; 0000-0001-6538-9705 ; 0000-0001-8393-1713 ; 0000-0002-5567-9618 ; 0000-0003-1852-9239 ; 0000-0002-1832-0307 ; 0000-0002-6740-0901 ; 0000-0002-4623-0544 ; 0000-0002-2291-372X ; 0000-0002-0888-8839</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,552,780,784,885,3356,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33737296$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:147193745$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Brown, Derek W</creatorcontrib><creatorcontrib>Lan, Qing</creatorcontrib><creatorcontrib>Rothman, Nathaniel</creatorcontrib><creatorcontrib>Pluta, John</creatorcontrib><creatorcontrib>Almstrup, Kristian</creatorcontrib><creatorcontrib>Dalgaard, Marlene D</creatorcontrib><creatorcontrib>Greene, Mark H</creatorcontrib><creatorcontrib>Grotmol, Tom</creatorcontrib><creatorcontrib>Loveday, Chey</creatorcontrib><creatorcontrib>Schwartz, Stephen M</creatorcontrib><creatorcontrib>Turnbull, Clare</creatorcontrib><creatorcontrib>Wiklund, Fredrik</creatorcontrib><creatorcontrib>Kanetsky, Peter A</creatorcontrib><creatorcontrib>Nathanson, Katherine L</creatorcontrib><creatorcontrib>McGlynn, Katherine A</creatorcontrib><creatorcontrib>Machiela, Mitchell J</creatorcontrib><creatorcontrib>Testicular Cancer Consortium</creatorcontrib><title>Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk</title><title>Cancer epidemiology, biomarkers & prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Studies evaluating the association between peripheral blood leukocyte telomere length (LTL) and testicular germ cell tumor (TGCT) risk have produced conflicting results.
Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.
Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).
Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.
The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.</description><subject>Case-Control Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Humans</subject><subject>Male</subject><subject>Medicin och hälsovetenskap</subject><subject>Mendelian Randomization Analysis</subject><subject>Neoplasms, Germ Cell and Embryonal - epidemiology</subject><subject>Neoplasms, Germ Cell and Embryonal - genetics</subject><subject>Risk Assessment - statistics & numerical data</subject><subject>Risk Factors</subject><subject>Telomere - metabolism</subject><subject>Telomere Homeostasis - genetics</subject><subject>Testicular Neoplasms - epidemiology</subject><subject>Testicular Neoplasms - genetics</subject><issn>1055-9965</issn><issn>1538-7755</issn><issn>1538-7755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1kU1PGzEQhq2qqHz1JxTtsZcFj-3ZtS-VqoiGSJFAKJwtZ3cMC_uR2lkQ_76OkkA5cPJo_Lzv2PMy9gP4OQDqC-CIuTEFnl_ezHLBcyhL_MKOAKXOU4lfU71nDtlxjI-c89IgfmOHUpayFKY4YldT6mndVK5tX7NZ7ykEqrMFtUNHgbI59ffrh8z1m15M3Ni6kE0pdNmE2jZbjN0QstsmPp2yA-_aSN935wm7-3O5mFzl8-vpbPJ7nlfKmHVe6KVXXKnaV54UCIkGqNaaQGkvC0nLykkFUCm91LzwUmgORhBqT8jRyxOWb33jC63GpV2FpnPh1Q6usbvWU6rIqkIqDYk3n_KrMNTvor0QVAlGlgqT9tdWm4CO6or6dXDtR4sPN33zYO-HZ6uhFCiKZPBzZxCGv2NaoO2aWKXFuZ6GMVqBPP2Zm0InFLdoFYYYA_m3McDtJnG7SdNu0rQpcStSN8WcdGf_v_FNtY9Y_gOvyakt</recordid><startdate>20210601</startdate><enddate>20210601</enddate><creator>Brown, Derek W</creator><creator>Lan, Qing</creator><creator>Rothman, Nathaniel</creator><creator>Pluta, John</creator><creator>Almstrup, Kristian</creator><creator>Dalgaard, Marlene D</creator><creator>Greene, Mark H</creator><creator>Grotmol, Tom</creator><creator>Loveday, Chey</creator><creator>Schwartz, Stephen M</creator><creator>Turnbull, Clare</creator><creator>Wiklund, Fredrik</creator><creator>Kanetsky, Peter A</creator><creator>Nathanson, Katherine L</creator><creator>McGlynn, Katherine A</creator><creator>Machiela, Mitchell J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0001-7499-8502</orcidid><orcidid>https://orcid.org/0000-0001-6538-9705</orcidid><orcidid>https://orcid.org/0000-0001-8393-1713</orcidid><orcidid>https://orcid.org/0000-0002-5567-9618</orcidid><orcidid>https://orcid.org/0000-0003-1852-9239</orcidid><orcidid>https://orcid.org/0000-0002-1832-0307</orcidid><orcidid>https://orcid.org/0000-0002-6740-0901</orcidid><orcidid>https://orcid.org/0000-0002-4623-0544</orcidid><orcidid>https://orcid.org/0000-0002-2291-372X</orcidid><orcidid>https://orcid.org/0000-0002-0888-8839</orcidid></search><sort><creationdate>20210601</creationdate><title>Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk</title><author>Brown, Derek W ; 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Using available genotype data from the Testicular Cancer Consortium (TECAC), polygenic risk score and Mendelian randomization analyses of genetic variants previously associated with LTL were used to assess potential etiologic associations between telomere length and TGCT risk.
Genetically inferred telomere length was not associated with TGCT risk among 2,049 cases and 6,921 controls with individual-level genotype data (OR, 1.02; 95% confidence interval, 0.97-1.07). Mendelian randomization analyses using summary statistic data further indicated no evidence for an association between telomere length and TGCT risk among all available TECAC participants (3,558 cases and 13,971 controls).
Our analyses in the largest molecular genetic testicular cancer study to date provide no evidence for an association between genetically inferred peripheral blood LTL and TGCT risk.
The lack of evidence for an overall association indicates that peripheral blood LTL is likely not a strong biomarker for TGCT risk.</abstract><cop>United States</cop><pmid>33737296</pmid><doi>10.1158/1055-9965.EPI-20-1775</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0001-7499-8502</orcidid><orcidid>https://orcid.org/0000-0001-6538-9705</orcidid><orcidid>https://orcid.org/0000-0001-8393-1713</orcidid><orcidid>https://orcid.org/0000-0002-5567-9618</orcidid><orcidid>https://orcid.org/0000-0003-1852-9239</orcidid><orcidid>https://orcid.org/0000-0002-1832-0307</orcidid><orcidid>https://orcid.org/0000-0002-6740-0901</orcidid><orcidid>https://orcid.org/0000-0002-4623-0544</orcidid><orcidid>https://orcid.org/0000-0002-2291-372X</orcidid><orcidid>https://orcid.org/0000-0002-0888-8839</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Case-Control Studies Genetic Predisposition to Disease Humans Male Medicin och hälsovetenskap Mendelian Randomization Analysis Neoplasms, Germ Cell and Embryonal - epidemiology Neoplasms, Germ Cell and Embryonal - genetics Risk Assessment - statistics & numerical data Risk Factors Telomere - metabolism Telomere Homeostasis - genetics Testicular Neoplasms - epidemiology Testicular Neoplasms - genetics |
| title | Genetically Inferred Telomere Length and Testicular Germ Cell Tumor Risk |
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