Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer
Background Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases. Meth...
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| Veröffentlicht in: | INTERNATIONAL JOURNAL OF EPIDEMIOLOGY 2021-08, Vol.50 (4), p.1325-1334 |
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| creator | Besson, Caroline Moore, Amy Wu, Wenting Vajdic, Claire M de Sanjose, Silvia Camp, Nicola J Smedby, Karin E Shanafelt, Tait D Morton, Lindsay M Brewer, Jerry D Zablotska, Lydia Engels, Eric A Cerhan, James R Slager, Susan L Han, Jiali Berndt, Sonja I |
| description | Background
Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases.
Methods
We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results
Higher CLL-PRS was associated with increased BCC risk (OR4th-quartile-vs-1st-quartile = 1.13, 95% CI: 1.02–1.24, Ptrend = 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (Ptrend = 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th-quartile-vs-1st-quartile = 1.22, 95% CI: 1.08–1.38, Ptrend = 1.36 × 10–5), which was driven by shared genetic susceptibility at the 6p25.3 locus.
Conclusion
These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk. |
| doi_str_mv | 10.1093/ije/dyab042 |
| format | Article |
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Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases.
Methods
We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results
Higher CLL-PRS was associated with increased BCC risk (OR4th-quartile-vs-1st-quartile = 1.13, 95% CI: 1.02–1.24, Ptrend = 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (Ptrend = 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th-quartile-vs-1st-quartile = 1.22, 95% CI: 1.08–1.38, Ptrend = 1.36 × 10–5), which was driven by shared genetic susceptibility at the 6p25.3 locus.
Conclusion
These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk.</description><identifier>ISSN: 0300-5771</identifier><identifier>EISSN: 1464-3685</identifier><identifier>DOI: 10.1093/ije/dyab042</identifier><identifier>PMID: 33748835</identifier><language>eng</language><publisher>England: Oxford University Press</publisher><subject>Carcinoma, Basal Cell - epidemiology ; Carcinoma, Basal Cell - genetics ; Carcinoma, Squamous Cell - epidemiology ; Carcinoma, Squamous Cell - genetics ; Genetics ; Humans ; Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology ; Leukemia, Lymphocytic, Chronic, B-Cell - genetics ; Polymorphism, Single Nucleotide ; Risk Factors ; Skin Neoplasms - epidemiology ; Skin Neoplasms - genetics</subject><ispartof>INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2021-08, Vol.50 (4), p.1325-1334</ispartof><rights>Published by Oxford University Press on behalf of the International Epidemiological Association 2021. This work is written by US Government employees and is in the public domain in the US. 2021</rights><rights>Published by Oxford University Press on behalf of the International Epidemiological Association 2021. This work is written by US Government employees and is in the public domain in the US.</rights><rights>Published by Oxford University Press on behalf of the International Epidemiological Association 2021. This work is written by US Government employees and is in the public domain in the US. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-2137b17518ffea8d0f2e70a62ba96663c2eb26218a7c87c39345c3c701bb56f23</citedby><cites>FETCH-LOGICAL-c450t-2137b17518ffea8d0f2e70a62ba96663c2eb26218a7c87c39345c3c701bb56f23</cites><orcidid>0000-0002-7482-178X ; 0000-0002-8309-7092 ; 0000-0003-4364-7173</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,550,776,780,881,1578,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33748835$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:147884622$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Besson, Caroline</creatorcontrib><creatorcontrib>Moore, Amy</creatorcontrib><creatorcontrib>Wu, Wenting</creatorcontrib><creatorcontrib>Vajdic, Claire M</creatorcontrib><creatorcontrib>de Sanjose, Silvia</creatorcontrib><creatorcontrib>Camp, Nicola J</creatorcontrib><creatorcontrib>Smedby, Karin E</creatorcontrib><creatorcontrib>Shanafelt, Tait D</creatorcontrib><creatorcontrib>Morton, Lindsay M</creatorcontrib><creatorcontrib>Brewer, Jerry D</creatorcontrib><creatorcontrib>Zablotska, Lydia</creatorcontrib><creatorcontrib>Engels, Eric A</creatorcontrib><creatorcontrib>Cerhan, James R</creatorcontrib><creatorcontrib>Slager, Susan L</creatorcontrib><creatorcontrib>Han, Jiali</creatorcontrib><creatorcontrib>Berndt, Sonja I</creatorcontrib><creatorcontrib>InterLymph Consortium. Full authors list is given at the end of the manuscript</creatorcontrib><creatorcontrib>the InterLymph Consortium. Full authors list is given at the end of the manuscript</creatorcontrib><title>Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer</title><title>INTERNATIONAL JOURNAL OF EPIDEMIOLOGY</title><addtitle>Int J Epidemiol</addtitle><description>Background
Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases.
Methods
We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results
Higher CLL-PRS was associated with increased BCC risk (OR4th-quartile-vs-1st-quartile = 1.13, 95% CI: 1.02–1.24, Ptrend = 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (Ptrend = 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th-quartile-vs-1st-quartile = 1.22, 95% CI: 1.08–1.38, Ptrend = 1.36 × 10–5), which was driven by shared genetic susceptibility at the 6p25.3 locus.
Conclusion
These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk.</description><subject>Carcinoma, Basal Cell - epidemiology</subject><subject>Carcinoma, Basal Cell - genetics</subject><subject>Carcinoma, Squamous Cell - epidemiology</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Genetics</subject><subject>Humans</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</subject><subject>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Risk Factors</subject><subject>Skin Neoplasms - epidemiology</subject><subject>Skin Neoplasms - genetics</subject><issn>0300-5771</issn><issn>1464-3685</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kc1v1DAQxS0EotvCiTvyCSGhUH87uSChFRSkSlzgbNneSeNubIc4odoD_zuudqnohZNHnt97M5qH0CtK3lPS8ctwC5e7g3VEsCdoQ4USDVetfIo2hBPSSK3pGTov5ZYQKoTonqMzzrVoWy436Pc2x5gTvoEES_B4yuMh5nkaQokF-5yWObh1AbxkvAyAbSnZB7uEqnGw3AEk7Ic5p6qtymnI_nDvM8K6txCDxTbtcMqpiTDalKPFZR-qxiYP8wv0rLdjgZen9wL9-Pzp-_ZLc_3t6uv243XjhSRLwyjXjmpJ274H2-5Iz0ATq5iznVKKewaOKUZbq32rPe-4kJ57TahzUvWMX6Dm6FvuYFqdmeYQ7Xww2QZz-trXCoxQXFBS-Q9HvnYi7DzUM9jxkexxJ4XB3ORfppV1Cy2rwduTwZx_rlAWE0PxMNYTQF6LYZJwpWWndUXfHVE_51Jm6B_GUGLuAzY1YHMKuNKv_93sgf2baAXeHIG8Tv91-gNCfrRQ</recordid><startdate>20210830</startdate><enddate>20210830</enddate><creator>Besson, Caroline</creator><creator>Moore, Amy</creator><creator>Wu, Wenting</creator><creator>Vajdic, Claire M</creator><creator>de Sanjose, Silvia</creator><creator>Camp, Nicola J</creator><creator>Smedby, Karin E</creator><creator>Shanafelt, Tait D</creator><creator>Morton, Lindsay M</creator><creator>Brewer, Jerry D</creator><creator>Zablotska, Lydia</creator><creator>Engels, Eric A</creator><creator>Cerhan, James R</creator><creator>Slager, Susan L</creator><creator>Han, Jiali</creator><creator>Berndt, Sonja I</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-7482-178X</orcidid><orcidid>https://orcid.org/0000-0002-8309-7092</orcidid><orcidid>https://orcid.org/0000-0003-4364-7173</orcidid></search><sort><creationdate>20210830</creationdate><title>Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer</title><author>Besson, Caroline ; Moore, Amy ; Wu, Wenting ; Vajdic, Claire M ; de Sanjose, Silvia ; Camp, Nicola J ; Smedby, Karin E ; Shanafelt, Tait D ; Morton, Lindsay M ; Brewer, Jerry D ; Zablotska, Lydia ; Engels, Eric A ; Cerhan, James R ; Slager, Susan L ; Han, Jiali ; Berndt, Sonja I</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c450t-2137b17518ffea8d0f2e70a62ba96663c2eb26218a7c87c39345c3c701bb56f23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Carcinoma, Basal Cell - epidemiology</topic><topic>Carcinoma, Basal Cell - genetics</topic><topic>Carcinoma, Squamous Cell - epidemiology</topic><topic>Carcinoma, Squamous Cell - genetics</topic><topic>Genetics</topic><topic>Humans</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology</topic><topic>Leukemia, Lymphocytic, Chronic, B-Cell - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Risk Factors</topic><topic>Skin Neoplasms - epidemiology</topic><topic>Skin Neoplasms - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Besson, Caroline</creatorcontrib><creatorcontrib>Moore, Amy</creatorcontrib><creatorcontrib>Wu, Wenting</creatorcontrib><creatorcontrib>Vajdic, Claire M</creatorcontrib><creatorcontrib>de Sanjose, Silvia</creatorcontrib><creatorcontrib>Camp, Nicola J</creatorcontrib><creatorcontrib>Smedby, Karin E</creatorcontrib><creatorcontrib>Shanafelt, Tait D</creatorcontrib><creatorcontrib>Morton, Lindsay M</creatorcontrib><creatorcontrib>Brewer, Jerry D</creatorcontrib><creatorcontrib>Zablotska, Lydia</creatorcontrib><creatorcontrib>Engels, Eric A</creatorcontrib><creatorcontrib>Cerhan, James R</creatorcontrib><creatorcontrib>Slager, Susan L</creatorcontrib><creatorcontrib>Han, Jiali</creatorcontrib><creatorcontrib>Berndt, Sonja I</creatorcontrib><creatorcontrib>InterLymph Consortium. Full authors list is given at the end of the manuscript</creatorcontrib><creatorcontrib>the InterLymph Consortium. Full authors list is given at the end of the manuscript</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>INTERNATIONAL JOURNAL OF EPIDEMIOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Besson, Caroline</au><au>Moore, Amy</au><au>Wu, Wenting</au><au>Vajdic, Claire M</au><au>de Sanjose, Silvia</au><au>Camp, Nicola J</au><au>Smedby, Karin E</au><au>Shanafelt, Tait D</au><au>Morton, Lindsay M</au><au>Brewer, Jerry D</au><au>Zablotska, Lydia</au><au>Engels, Eric A</au><au>Cerhan, James R</au><au>Slager, Susan L</au><au>Han, Jiali</au><au>Berndt, Sonja I</au><aucorp>InterLymph Consortium. Full authors list is given at the end of the manuscript</aucorp><aucorp>the InterLymph Consortium. Full authors list is given at the end of the manuscript</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer</atitle><jtitle>INTERNATIONAL JOURNAL OF EPIDEMIOLOGY</jtitle><addtitle>Int J Epidemiol</addtitle><date>2021-08-30</date><risdate>2021</risdate><volume>50</volume><issue>4</issue><spage>1325</spage><epage>1334</epage><pages>1325-1334</pages><issn>0300-5771</issn><eissn>1464-3685</eissn><abstract>Background
Epidemiological studies have demonstrated a positive association between chronic lymphocytic leukaemia (CLL) and non-melanoma skin cancer (NMSC). We hypothesized that shared genetic risk factors between CLL and NMSC could contribute to the association observed between these diseases.
Methods
We examined the association between (i) established NMSC susceptibility loci and CLL risk in a meta-analysis including 3100 CLL cases and 7667 controls and (ii) established CLL loci and NMSC risk in a study of 4242 basal cell carcinoma (BCC) cases, 825 squamous cell carcinoma (SCC) cases and 12802 controls. Polygenic risk scores (PRS) for CLL, BCC and SCC were constructed using established loci. Logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
Results
Higher CLL-PRS was associated with increased BCC risk (OR4th-quartile-vs-1st-quartile = 1.13, 95% CI: 1.02–1.24, Ptrend = 0.009), even after removing the shared 6p25.3 locus. No association was observed with BCC-PRS and CLL risk (Ptrend = 0.68). These findings support a contributory role for CLL in BCC risk, but not for BCC in CLL risk. Increased CLL risk was observed with higher SCC-PRS (OR4th-quartile-vs-1st-quartile = 1.22, 95% CI: 1.08–1.38, Ptrend = 1.36 × 10–5), which was driven by shared genetic susceptibility at the 6p25.3 locus.
Conclusion
These findings highlight the role of pleiotropy regarding the pathogenesis of CLL and NMSC and shows that a single pleiotropic locus, 6p25.3, drives the observed association between genetic susceptibility to SCC and increased CLL risk. The study also provides evidence that genetic susceptibility for CLL increases BCC risk.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>33748835</pmid><doi>10.1093/ije/dyab042</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-7482-178X</orcidid><orcidid>https://orcid.org/0000-0002-8309-7092</orcidid><orcidid>https://orcid.org/0000-0003-4364-7173</orcidid><oa>free_for_read</oa></addata></record> |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Carcinoma, Basal Cell - epidemiology Carcinoma, Basal Cell - genetics Carcinoma, Squamous Cell - epidemiology Carcinoma, Squamous Cell - genetics Genetics Humans Leukemia, Lymphocytic, Chronic, B-Cell - epidemiology Leukemia, Lymphocytic, Chronic, B-Cell - genetics Polymorphism, Single Nucleotide Risk Factors Skin Neoplasms - epidemiology Skin Neoplasms - genetics |
| title | Common genetic polymorphisms contribute to the association between chronic lymphocytic leukaemia and non-melanoma skin cancer |
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