PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion

Dysregulation of the developmentally important Notch signaling pathway is implicated in several types of cancer, including breast cancer. However, the specific roles and regulation of the four different Notch receptors have remained elusive. We have previously reported that the oncogenic PIM kinases...

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Veröffentlicht in:	JOURNAL OF BIOLOGICAL CHEMISTRY 2021-01, Vol.296, p.100593-100593, Article 100593
Hauptverfasser:	Landor, Sebastian K.J., Santio, Niina M., Eccleshall, William B., Paramonov, Valeriy M., Gagliani, Ellen K., Hall, Daniel, Jin, Shao-Bo, Dahlström, Käthe M., Salminen, Tiina A., Rivero-Müller, Adolfo, Lendahl, Urban, Kovall, Rhett A., Koskinen, Päivi J., Sahlgren, Cecilia
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Active Transport, Cell Nucleus Animals breast cancer Breast Neoplasms - pathology Carcinogenesis Cell Line, Tumor Cell Nucleus - metabolism Humans Immunoglobulin J Recombination Signal Sequence-Binding Protein - metabolism Medicin och hälsovetenskap Mice Models, Molecular Muscle Proteins - metabolism Notch proteins Phosphorylation PIM kinases Protein Domains protein–protein interaction Proto-Oncogene Proteins c-pim-1 - metabolism Receptor, Notch3 - chemistry Receptor, Notch3 - metabolism transcription regulation tumor cell biology
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