Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

Characterization of the progression of cellular states during human embryogenesis can provide insights into the origin of pediatric diseases. We examined the transcriptional states of neural crest– and mesoderm-derived lineages differentiating into adrenal glands, kidneys, endothelium and hematopoie...

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Veröffentlicht in:	Nature genetics 2021-05, Vol.53 (5), p.694-706
Hauptverfasser:	Kameneva, Polina, Artemov, Artem V., Kastriti, Maria Eleni, Faure, Louis, Olsen, Thale K., Otte, Jörg, Erickson, Alek, Semsch, Bettina, Andersson, Emma R., Ratz, Michael, Frisén, Jonas, Tischler, Arthur S., de Krijger, Ronald R., Bouderlique, Thibault, Akkuratova, Natalia, Vorontsova, Maria, Gusev, Oleg, Fried, Kaj, Sundström, Erik, Mei, Shenglin, Kogner, Per, Baryawno, Ninib, Kharchenko, Peter V., Adameyko, Igor
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 14/19 38/91 42/44 631/114 631/136 631/208 631/67 631/67/1678 64/60 Adrenal glands Agriculture Animal Genetics and Genomics Animals Biomedical and Life Sciences Biomedicine Cancer Cancer Research Cell cycle Cell development (Biology) Cell Lineage Cell lines Chromaffin cells Chromaffin Cells - metabolism Chromaffin Cells - pathology Cluster Analysis Coronary vessels Development and progression Embryo, Mammalian - metabolism Embryogenesis Embryonic Development Embryonic growth stage Embryos Endothelium Ganglia Gene Expression Regulation, Developmental Gene Expression Regulation, Neoplastic Gene Function Genetic aspects Health aspects Hematopoietic system Hemopoiesis Human Genetics Humans Identification and classification Infant Kidneys Mesoderm Methods Mice Neural crest Neural stem cells Neural Stem Cells - metabolism Neuroblastoma Neuroblastoma - embryology Neuroblastoma - genetics Neuroblastoma - pathology Pediatrics Primordia RNA sequencing Schwann Cells - metabolism Schwann Cells - pathology Single-Cell Analysis Sympathoadrenal System - embryology Transcription Transcriptome - genetics Tumor Microenvironment Tumors
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