Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals

Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and...

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Veröffentlicht in:Molecular psychiatry 2021-11, Vol.26 (11), p.6806-6819
Hauptverfasser: McWhinney, Sean R., Abé, Christoph, Alda, Martin, Benedetti, Francesco, Bøen, Erlend, del Mar Bonnin, Caterina, Borgers, Tiana, Brosch, Katharina, Canales-Rodríguez, Erick J., Cannon, Dara M., Dannlowski, Udo, Díaz-Zuluaga, Ana M., Elvsåshagen, Torbjørn, Eyler, Lisa T., Fullerton, Janice M., Goikolea, Jose M., Goltermann, Janik, Grotegerd, Dominik, Haarman, Bartholomeus C. M., Hahn, Tim, Howells, Fleur M., Ingvar, Martin, Kircher, Tilo T. J., Krug, Axel, Kuplicki, Rayus T., Landén, Mikael, Lemke, Hannah, Liberg, Benny, Lopez-Jaramillo, Carlos, Malt, Ulrik F., Martyn, Fiona M., Mazza, Elena, McDonald, Colm, McPhilemy, Genevieve, Meier, Sandra, Meinert, Susanne, Meller, Tina, Melloni, Elisa M. T., Mitchell, Philip B., Nabulsi, Leila, Nenadic, Igor, Opel, Nils, Ophoff, Roel A., Overs, Bronwyn J., Pfarr, Julia-Katharina, Pineda-Zapata, Julian A., Pomarol-Clotet, Edith, Raduà, Joaquim, Repple, Jonathan, Richter, Maike, Ringwald, Kai G., Roberts, Gloria, Salvador, Raymond, Savitz, Jonathan, Schmitt, Simon, Schofield, Peter R., Sim, Kang, Stein, Dan J., Stein, Frederike, Temmingh, Henk S., Thiel, Katharina, van Haren, Neeltje E. M., Gestel, Holly Van, Vargas, Cristian, Vieta, Eduard, Vreeker, Annabel, Waltemate, Lena, Yatham, Lakshmi N., Ching, Christopher R. K., Andreassen, Ole, Thompson, Paul M., Hajek, Tomas
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container_end_page 6819
container_issue 11
container_start_page 6806
container_title Molecular psychiatry
container_volume 26
creator McWhinney, Sean R.
Abé, Christoph
Alda, Martin
Benedetti, Francesco
Bøen, Erlend
del Mar Bonnin, Caterina
Borgers, Tiana
Brosch, Katharina
Canales-Rodríguez, Erick J.
Cannon, Dara M.
Dannlowski, Udo
Díaz-Zuluaga, Ana M.
Elvsåshagen, Torbjørn
Eyler, Lisa T.
Fullerton, Janice M.
Goikolea, Jose M.
Goltermann, Janik
Grotegerd, Dominik
Haarman, Bartholomeus C. M.
Hahn, Tim
Howells, Fleur M.
Ingvar, Martin
Kircher, Tilo T. J.
Krug, Axel
Kuplicki, Rayus T.
Landén, Mikael
Lemke, Hannah
Liberg, Benny
Lopez-Jaramillo, Carlos
Malt, Ulrik F.
Martyn, Fiona M.
Mazza, Elena
McDonald, Colm
McPhilemy, Genevieve
Meier, Sandra
Meinert, Susanne
Meller, Tina
Melloni, Elisa M. T.
Mitchell, Philip B.
Nabulsi, Leila
Nenadic, Igor
Opel, Nils
Ophoff, Roel A.
Overs, Bronwyn J.
Pfarr, Julia-Katharina
Pineda-Zapata, Julian A.
Pomarol-Clotet, Edith
Raduà, Joaquim
Repple, Jonathan
Richter, Maike
Ringwald, Kai G.
Roberts, Gloria
Salvador, Raymond
Savitz, Jonathan
Schmitt, Simon
Schofield, Peter R.
Sim, Kang
Stein, Dan J.
Stein, Frederike
Temmingh, Henk S.
Thiel, Katharina
van Haren, Neeltje E. M.
Gestel, Holly Van
Vargas, Cristian
Vieta, Eduard
Vreeker, Annabel
Waltemate, Lena
Yatham, Lakshmi N.
Ching, Christopher R. K.
Andreassen, Ole
Thompson, Paul M.
Hajek, Tomas
description Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI ( Z  = 2.73, p  = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.
doi_str_mv 10.1038/s41380-021-01098-x
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K. ; Andreassen, Ole ; Thompson, Paul M. ; Hajek, Tomas</creator><creatorcontrib>McWhinney, Sean R. ; Abé, Christoph ; Alda, Martin ; Benedetti, Francesco ; Bøen, Erlend ; del Mar Bonnin, Caterina ; Borgers, Tiana ; Brosch, Katharina ; Canales-Rodríguez, Erick J. ; Cannon, Dara M. ; Dannlowski, Udo ; Díaz-Zuluaga, Ana M. ; Elvsåshagen, Torbjørn ; Eyler, Lisa T. ; Fullerton, Janice M. ; Goikolea, Jose M. ; Goltermann, Janik ; Grotegerd, Dominik ; Haarman, Bartholomeus C. M. ; Hahn, Tim ; Howells, Fleur M. ; Ingvar, Martin ; Kircher, Tilo T. J. ; Krug, Axel ; Kuplicki, Rayus T. ; Landén, Mikael ; Lemke, Hannah ; Liberg, Benny ; Lopez-Jaramillo, Carlos ; Malt, Ulrik F. ; Martyn, Fiona M. ; Mazza, Elena ; McDonald, Colm ; McPhilemy, Genevieve ; Meier, Sandra ; Meinert, Susanne ; Meller, Tina ; Melloni, Elisa M. T. ; Mitchell, Philip B. ; Nabulsi, Leila ; Nenadic, Igor ; Opel, Nils ; Ophoff, Roel A. ; Overs, Bronwyn J. ; Pfarr, Julia-Katharina ; Pineda-Zapata, Julian A. ; Pomarol-Clotet, Edith ; Raduà, Joaquim ; Repple, Jonathan ; Richter, Maike ; Ringwald, Kai G. ; Roberts, Gloria ; Salvador, Raymond ; Savitz, Jonathan ; Schmitt, Simon ; Schofield, Peter R. ; Sim, Kang ; Stein, Dan J. ; Stein, Frederike ; Temmingh, Henk S. ; Thiel, Katharina ; van Haren, Neeltje E. M. ; Gestel, Holly Van ; Vargas, Cristian ; Vieta, Eduard ; Vreeker, Annabel ; Waltemate, Lena ; Yatham, Lakshmi N. ; Ching, Christopher R. K. ; Andreassen, Ole ; Thompson, Paul M. ; Hajek, Tomas ; ENIGMA Bipolar Disorders Working Group ; for the ENIGMA Bipolar Disorders Working Group</creatorcontrib><description>Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI ( Z  = 2.73, p  = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.</description><identifier>ISSN: 1359-4184</identifier><identifier>ISSN: 1476-5578</identifier><identifier>EISSN: 1476-5578</identifier><identifier>DOI: 10.1038/s41380-021-01098-x</identifier><identifier>PMID: 33863996</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>59/57 ; 631/378 ; 692/699/476/1333 ; Amygdala ; Behavioral Sciences ; Biological Psychology ; Bipolar Disorder ; Body Mass Index ; Brain ; Brain research ; Clinical Medicine ; Diagnosis ; Globus pallidus ; Humans ; Klinisk medicin ; Magnetic resonance imaging ; Magnetic Resonance Imaging - methods ; Measurement ; Medicin och hälsovetenskap ; Medicine ; Medicine &amp; Public Health ; Neuroimaging ; Neurosciences ; Obesity ; Pharmacotherapy ; Physiological aspects ; Psychiatry ; Psykiatri ; Risk factors ; Thalamus ; Ventricle ; Ventricle (lateral)</subject><ispartof>Molecular psychiatry, 2021-11, Vol.26 (11), p.6806-6819</ispartof><rights>The Author(s) 2021</rights><rights>2021. 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M.</creatorcontrib><creatorcontrib>Hahn, Tim</creatorcontrib><creatorcontrib>Howells, Fleur M.</creatorcontrib><creatorcontrib>Ingvar, Martin</creatorcontrib><creatorcontrib>Kircher, Tilo T. J.</creatorcontrib><creatorcontrib>Krug, Axel</creatorcontrib><creatorcontrib>Kuplicki, Rayus T.</creatorcontrib><creatorcontrib>Landén, Mikael</creatorcontrib><creatorcontrib>Lemke, Hannah</creatorcontrib><creatorcontrib>Liberg, Benny</creatorcontrib><creatorcontrib>Lopez-Jaramillo, Carlos</creatorcontrib><creatorcontrib>Malt, Ulrik F.</creatorcontrib><creatorcontrib>Martyn, Fiona M.</creatorcontrib><creatorcontrib>Mazza, Elena</creatorcontrib><creatorcontrib>McDonald, Colm</creatorcontrib><creatorcontrib>McPhilemy, Genevieve</creatorcontrib><creatorcontrib>Meier, Sandra</creatorcontrib><creatorcontrib>Meinert, Susanne</creatorcontrib><creatorcontrib>Meller, Tina</creatorcontrib><creatorcontrib>Melloni, Elisa M. 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M.</creatorcontrib><creatorcontrib>Gestel, Holly Van</creatorcontrib><creatorcontrib>Vargas, Cristian</creatorcontrib><creatorcontrib>Vieta, Eduard</creatorcontrib><creatorcontrib>Vreeker, Annabel</creatorcontrib><creatorcontrib>Waltemate, Lena</creatorcontrib><creatorcontrib>Yatham, Lakshmi N.</creatorcontrib><creatorcontrib>Ching, Christopher R. K.</creatorcontrib><creatorcontrib>Andreassen, Ole</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Hajek, Tomas</creatorcontrib><creatorcontrib>ENIGMA Bipolar Disorders Working Group</creatorcontrib><creatorcontrib>for the ENIGMA Bipolar Disorders Working Group</creatorcontrib><title>Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals</title><title>Molecular psychiatry</title><addtitle>Mol Psychiatry</addtitle><addtitle>Mol Psychiatry</addtitle><description>Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI ( Z  = 2.73, p  = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.</description><subject>59/57</subject><subject>631/378</subject><subject>692/699/476/1333</subject><subject>Amygdala</subject><subject>Behavioral Sciences</subject><subject>Biological Psychology</subject><subject>Bipolar Disorder</subject><subject>Body Mass Index</subject><subject>Brain</subject><subject>Brain research</subject><subject>Clinical Medicine</subject><subject>Diagnosis</subject><subject>Globus pallidus</subject><subject>Humans</subject><subject>Klinisk medicin</subject><subject>Magnetic resonance imaging</subject><subject>Magnetic Resonance Imaging - methods</subject><subject>Measurement</subject><subject>Medicin och hälsovetenskap</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Neuroimaging</subject><subject>Neurosciences</subject><subject>Obesity</subject><subject>Pharmacotherapy</subject><subject>Physiological aspects</subject><subject>Psychiatry</subject><subject>Psykiatri</subject><subject>Risk factors</subject><subject>Thalamus</subject><subject>Ventricle</subject><subject>Ventricle (lateral)</subject><issn>1359-4184</issn><issn>1476-5578</issn><issn>1476-5578</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>3HK</sourceid><sourceid>D8T</sourceid><recordid>eNp9ks1u1DAQxyMEoqXwAhwgUi9cUsZfiX1BWlWlVCpwgbPlxM7iktiLnWx3b7wDb8iT4LC7XRZB5cNYM7_5z3g8WfYcwRkCwl9HigiHAjAqAIHgxepBdoxoVRaMVfxhuhMmCoo4PcqexHgDMAXZ4-yIEF4SIcrjbD2L0TdWDda7vDbDrTHJer3OexVjbp02q1w5ncexbnwYbKO6vA7Kunzpu7E3E5PXduE7FXJtow_ahPjz-4-LD1eX72d5HMYklhhcETbp2aXVo-ri0-xRm4x5trUn2ee3F5_O3xXXHy-vzmfXRVMKNBS6aQ2AVkqbusJYaQoGoYrXQtCyaTRqiSKgqSItIYpTBhqwRgxQq7WqDTnJio1uvDWLsZaLYHsV1tIrK7eur-lmJC1xhUnixX_5RfB6n7RLRLSkTKRu7601HxcyuebjlEKAYl4l_s2GT3BvdGPcEFR3WPIg4uwXOfdLyasSgE4CLzcCTbBxsE46H5REwBmWgkDFE_FqWyL4b6OJg-xtbEzXKWf8GCVmqX0QiOOEnv6F3vgxuPQ5EpdIlAgBQ3tqrjojrWt96qyZROUszQAEw3TSOvsHlY42vW28M61N_oMEvHuJjzGY9m4KCOS07nKz7jKtu_y97nKVkl78Ob-7lN1-J4BsPySF3NyE_ZPukf0FlawOBw</recordid><startdate>20211101</startdate><enddate>20211101</enddate><creator>McWhinney, Sean R.</creator><creator>Abé, Christoph</creator><creator>Alda, Martin</creator><creator>Benedetti, Francesco</creator><creator>Bøen, Erlend</creator><creator>del Mar Bonnin, Caterina</creator><creator>Borgers, Tiana</creator><creator>Brosch, Katharina</creator><creator>Canales-Rodríguez, Erick J.</creator><creator>Cannon, Dara M.</creator><creator>Dannlowski, Udo</creator><creator>Díaz-Zuluaga, Ana M.</creator><creator>Elvsåshagen, Torbjørn</creator><creator>Eyler, Lisa T.</creator><creator>Fullerton, Janice M.</creator><creator>Goikolea, Jose M.</creator><creator>Goltermann, Janik</creator><creator>Grotegerd, Dominik</creator><creator>Haarman, Bartholomeus C. 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M. ; Hahn, Tim ; Howells, Fleur M. ; Ingvar, Martin ; Kircher, Tilo T. J. ; Krug, Axel ; Kuplicki, Rayus T. ; Landén, Mikael ; Lemke, Hannah ; Liberg, Benny ; Lopez-Jaramillo, Carlos ; Malt, Ulrik F. ; Martyn, Fiona M. ; Mazza, Elena ; McDonald, Colm ; McPhilemy, Genevieve ; Meier, Sandra ; Meinert, Susanne ; Meller, Tina ; Melloni, Elisa M. T. ; Mitchell, Philip B. ; Nabulsi, Leila ; Nenadic, Igor ; Opel, Nils ; Ophoff, Roel A. ; Overs, Bronwyn J. ; Pfarr, Julia-Katharina ; Pineda-Zapata, Julian A. ; Pomarol-Clotet, Edith ; Raduà, Joaquim ; Repple, Jonathan ; Richter, Maike ; Ringwald, Kai G. ; Roberts, Gloria ; Salvador, Raymond ; Savitz, Jonathan ; Schmitt, Simon ; Schofield, Peter R. ; Sim, Kang ; Stein, Dan J. ; Stein, Frederike ; Temmingh, Henk S. ; Thiel, Katharina ; van Haren, Neeltje E. M. ; Gestel, Holly Van ; Vargas, Cristian ; Vieta, Eduard ; Vreeker, Annabel ; Waltemate, Lena ; Yatham, Lakshmi N. ; Ching, Christopher R. K. ; Andreassen, Ole ; Thompson, Paul M. ; Hajek, Tomas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c691t-dcfe00daadeb722ad40e1178b9946ccd1f3a30d4a3f33a8450d02d1501fddabe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>59/57</topic><topic>631/378</topic><topic>692/699/476/1333</topic><topic>Amygdala</topic><topic>Behavioral Sciences</topic><topic>Biological Psychology</topic><topic>Bipolar Disorder</topic><topic>Body Mass Index</topic><topic>Brain</topic><topic>Brain research</topic><topic>Clinical Medicine</topic><topic>Diagnosis</topic><topic>Globus pallidus</topic><topic>Humans</topic><topic>Klinisk medicin</topic><topic>Magnetic resonance imaging</topic><topic>Magnetic Resonance Imaging - methods</topic><topic>Measurement</topic><topic>Medicin och hälsovetenskap</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Neuroimaging</topic><topic>Neurosciences</topic><topic>Obesity</topic><topic>Pharmacotherapy</topic><topic>Physiological aspects</topic><topic>Psychiatry</topic><topic>Psykiatri</topic><topic>Risk factors</topic><topic>Thalamus</topic><topic>Ventricle</topic><topic>Ventricle (lateral)</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McWhinney, Sean R.</creatorcontrib><creatorcontrib>Abé, Christoph</creatorcontrib><creatorcontrib>Alda, Martin</creatorcontrib><creatorcontrib>Benedetti, Francesco</creatorcontrib><creatorcontrib>Bøen, Erlend</creatorcontrib><creatorcontrib>del Mar Bonnin, Caterina</creatorcontrib><creatorcontrib>Borgers, Tiana</creatorcontrib><creatorcontrib>Brosch, Katharina</creatorcontrib><creatorcontrib>Canales-Rodríguez, Erick J.</creatorcontrib><creatorcontrib>Cannon, Dara M.</creatorcontrib><creatorcontrib>Dannlowski, Udo</creatorcontrib><creatorcontrib>Díaz-Zuluaga, Ana M.</creatorcontrib><creatorcontrib>Elvsåshagen, Torbjørn</creatorcontrib><creatorcontrib>Eyler, Lisa T.</creatorcontrib><creatorcontrib>Fullerton, Janice M.</creatorcontrib><creatorcontrib>Goikolea, Jose M.</creatorcontrib><creatorcontrib>Goltermann, Janik</creatorcontrib><creatorcontrib>Grotegerd, Dominik</creatorcontrib><creatorcontrib>Haarman, Bartholomeus C. 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K.</creatorcontrib><creatorcontrib>Andreassen, Ole</creatorcontrib><creatorcontrib>Thompson, Paul M.</creatorcontrib><creatorcontrib>Hajek, Tomas</creatorcontrib><creatorcontrib>ENIGMA Bipolar Disorders Working Group</creatorcontrib><creatorcontrib>for the ENIGMA Bipolar Disorders Working Group</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Molecular psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McWhinney, Sean R.</au><au>Abé, Christoph</au><au>Alda, Martin</au><au>Benedetti, Francesco</au><au>Bøen, Erlend</au><au>del Mar Bonnin, Caterina</au><au>Borgers, Tiana</au><au>Brosch, Katharina</au><au>Canales-Rodríguez, Erick J.</au><au>Cannon, Dara M.</au><au>Dannlowski, Udo</au><au>Díaz-Zuluaga, Ana M.</au><au>Elvsåshagen, Torbjørn</au><au>Eyler, Lisa T.</au><au>Fullerton, Janice M.</au><au>Goikolea, Jose M.</au><au>Goltermann, Janik</au><au>Grotegerd, Dominik</au><au>Haarman, Bartholomeus C. M.</au><au>Hahn, Tim</au><au>Howells, Fleur M.</au><au>Ingvar, Martin</au><au>Kircher, Tilo T. J.</au><au>Krug, Axel</au><au>Kuplicki, Rayus T.</au><au>Landén, Mikael</au><au>Lemke, Hannah</au><au>Liberg, Benny</au><au>Lopez-Jaramillo, Carlos</au><au>Malt, Ulrik F.</au><au>Martyn, Fiona M.</au><au>Mazza, Elena</au><au>McDonald, Colm</au><au>McPhilemy, Genevieve</au><au>Meier, Sandra</au><au>Meinert, Susanne</au><au>Meller, Tina</au><au>Melloni, Elisa M. T.</au><au>Mitchell, Philip B.</au><au>Nabulsi, Leila</au><au>Nenadic, Igor</au><au>Opel, Nils</au><au>Ophoff, Roel A.</au><au>Overs, Bronwyn J.</au><au>Pfarr, Julia-Katharina</au><au>Pineda-Zapata, Julian A.</au><au>Pomarol-Clotet, Edith</au><au>Raduà, Joaquim</au><au>Repple, Jonathan</au><au>Richter, Maike</au><au>Ringwald, Kai G.</au><au>Roberts, Gloria</au><au>Salvador, Raymond</au><au>Savitz, Jonathan</au><au>Schmitt, Simon</au><au>Schofield, Peter R.</au><au>Sim, Kang</au><au>Stein, Dan J.</au><au>Stein, Frederike</au><au>Temmingh, Henk S.</au><au>Thiel, Katharina</au><au>van Haren, Neeltje E. M.</au><au>Gestel, Holly Van</au><au>Vargas, Cristian</au><au>Vieta, Eduard</au><au>Vreeker, Annabel</au><au>Waltemate, Lena</au><au>Yatham, Lakshmi N.</au><au>Ching, Christopher R. K.</au><au>Andreassen, Ole</au><au>Thompson, Paul M.</au><au>Hajek, Tomas</au><aucorp>ENIGMA Bipolar Disorders Working Group</aucorp><aucorp>for the ENIGMA Bipolar Disorders Working Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals</atitle><jtitle>Molecular psychiatry</jtitle><stitle>Mol Psychiatry</stitle><addtitle>Mol Psychiatry</addtitle><date>2021-11-01</date><risdate>2021</risdate><volume>26</volume><issue>11</issue><spage>6806</spage><epage>6819</epage><pages>6806-6819</pages><issn>1359-4184</issn><issn>1476-5578</issn><eissn>1476-5578</eissn><abstract>Individuals with bipolar disorders (BD) frequently suffer from obesity, which is often associated with neurostructural alterations. Yet, the effects of obesity on brain structure in BD are under-researched. We obtained MRI-derived brain subcortical volumes and body mass index (BMI) from 1134 BD and 1601 control individuals from 17 independent research sites within the ENIGMA-BD Working Group. We jointly modeled the effects of BD and BMI on subcortical volumes using mixed-effects modeling and tested for mediation of group differences by obesity using nonparametric bootstrapping. All models controlled for age, sex, hemisphere, total intracranial volume, and data collection site. Relative to controls, individuals with BD had significantly higher BMI, larger lateral ventricular volume, and smaller volumes of amygdala, hippocampus, pallidum, caudate, and thalamus. BMI was positively associated with ventricular and amygdala and negatively with pallidal volumes. When analyzed jointly, both BD and BMI remained associated with volumes of lateral ventricles  and amygdala. Adjusting for BMI decreased the BD vs control differences in ventricular volume. Specifically, 18.41% of the association between BD and ventricular volume was mediated by BMI ( Z  = 2.73, p  = 0.006). BMI was associated with similar regional brain volumes as BD, including lateral ventricles, amygdala, and pallidum. Higher BMI may in part account for larger ventricles, one of the most replicated findings in BD. Comorbidity with obesity could explain why neurostructural alterations are more pronounced in some individuals with BD. Future prospective brain imaging studies should investigate whether obesity could be a modifiable risk factor for neuroprogression.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>33863996</pmid><doi>10.1038/s41380-021-01098-x</doi><tpages>14</tpages><orcidid>https://orcid.org/0000-0003-4014-4490</orcidid><orcidid>https://orcid.org/0000-0002-9881-2511</orcidid><orcidid>https://orcid.org/0000-0003-1661-5192</orcidid><orcidid>https://orcid.org/0000-0001-7331-0534</orcidid><orcidid>https://orcid.org/0000-0002-7138-5556</orcidid><orcidid>https://orcid.org/0000-0001-9448-7769</orcidid><orcidid>https://orcid.org/0000-0002-9546-2763</orcidid><orcidid>https://orcid.org/0000-0003-2967-9662</orcidid><orcidid>https://orcid.org/0000-0001-6421-2633</orcidid><orcidid>https://orcid.org/0000-0002-0564-2497</orcidid><orcidid>https://orcid.org/0000-0002-1680-8480</orcidid><orcidid>https://orcid.org/0000-0003-3087-1002</orcidid><orcidid>https://orcid.org/0000-0002-2621-2920</orcidid><orcidid>https://orcid.org/0000-0002-8287-6457</orcidid><orcidid>https://orcid.org/0000-0001-7378-3411</orcidid><orcidid>https://orcid.org/0000-0003-4949-856X</orcidid><orcidid>https://orcid.org/0000-0003-0281-8458</orcidid><orcidid>https://orcid.org/0000-0001-9991-1610</orcidid><orcidid>https://orcid.org/0000-0002-4461-3568</orcidid><orcidid>https://orcid.org/0000-0001-8143-182X</orcidid><orcidid>https://orcid.org/0000-0003-3209-9626</orcidid><orcidid>https://orcid.org/0000-0001-7218-7810</orcidid><orcidid>https://orcid.org/0000-0002-7954-5235</orcidid><oa>free_for_read</oa></addata></record>
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identifier ISSN: 1359-4184
ispartof Molecular psychiatry, 2021-11, Vol.26 (11), p.6806-6819
issn 1359-4184
1476-5578
1476-5578
language eng
recordid cdi_swepub_primary_oai_swepub_ki_se_462723
source MEDLINE; NORA - Norwegian Open Research Archives; SWEPUB Freely available online; Alma/SFX Local Collection
subjects 59/57
631/378
692/699/476/1333
Amygdala
Behavioral Sciences
Biological Psychology
Bipolar Disorder
Body Mass Index
Brain
Brain research
Clinical Medicine
Diagnosis
Globus pallidus
Humans
Klinisk medicin
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Measurement
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Neuroimaging
Neurosciences
Obesity
Pharmacotherapy
Physiological aspects
Psychiatry
Psykiatri
Risk factors
Thalamus
Ventricle
Ventricle (lateral)
title Association between body mass index and subcortical brain volumes in bipolar disorders–ENIGMA study in 2735 individuals
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