Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries
The objective of the SMINC-2 (Stockholm Myocardial Infarction With Normal Coronaries 2) study was to determine if more than 70% of patients with myocardial infarction with nonobstructed coronary arteries (MINOCA), investigated early with comprehensive cardiovascular magnetic resonance (CMR), could r...
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| Veröffentlicht in: | JACC. Cardiovascular imaging 2021-09, Vol.14 (9), p.1774-1783 |
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| creator | Sörensson, Peder Ekenbäck, Christina Lundin, Magnus Agewall, Stefan Bacsovics Brolin, Elin Caidahl, Kenneth Cederlund, Kerstin Collste, Olov Daniel, Maria Jensen, Jens Y-Hassan, Shams Henareh, Loghman Hofman-Bang, Claes Lyngå, Patrik Maret, Eva Sarkar, Nondita Spaak, Jonas Winnberg, Oscar Ugander, Martin Tornvall, Per |
| description | The objective of the SMINC-2 (Stockholm Myocardial Infarction With Normal Coronaries 2) study was to determine if more than 70% of patients with myocardial infarction with nonobstructed coronary arteries (MINOCA), investigated early with comprehensive cardiovascular magnetic resonance (CMR), could receive a diagnosis entirely by imaging.
The etiology of MINOCA is heterogeneous, including coronary, cardiac, and noncardiac causes. Patients with MINOCA, therefore, represent a diagnostic challenge where CMR is increasingly used.
The SMINC-2 study was a prospective study of 148 patients with MINOCA imaged with 1.5-T CMR with T1 and extracellular volume mapping early after hospital admission, compared to 150 patients with MINOCA imaged using 1.5-T CMR without mapping techniques from the SMINC-1 study as historic controls.
CMR was performed at a median of 3 (SMINC-2) versus 12 (SMINC-1) days after hospital admission. In total, 77% of patients received a diagnosis with CMR imaging in the SMINC-2 study compared to 47% in the SMINC-1 study (p |
| doi_str_mv | 10.1016/j.jcmg.2021.02.021 |
| format | Article |
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The etiology of MINOCA is heterogeneous, including coronary, cardiac, and noncardiac causes. Patients with MINOCA, therefore, represent a diagnostic challenge where CMR is increasingly used.
The SMINC-2 study was a prospective study of 148 patients with MINOCA imaged with 1.5-T CMR with T1 and extracellular volume mapping early after hospital admission, compared to 150 patients with MINOCA imaged using 1.5-T CMR without mapping techniques from the SMINC-1 study as historic controls.
CMR was performed at a median of 3 (SMINC-2) versus 12 (SMINC-1) days after hospital admission. In total, 77% of patients received a diagnosis with CMR imaging in the SMINC-2 study compared to 47% in the SMINC-1 study (p < 0.001). Compared to SMINC-1, CMR in SMINC-2 detected higher proportions of myocarditis (17% vs. 7%; p = 0.01) and takotsubo syndrome (35% vs. 19%; p = 0.002) but similar proportions of myocardial infarction (22% vs. 19%; p = 0.56) and other cardiomyopathies (3% vs. 2%; p = 0.46).
The results of the SMINC-2 study show that 77% of all patients with MINOCA received a diagnosis when imaged early with CMR, including advanced tissue characterization, which was a considerable improvement in comparison to the SMINC-1 study. This supports the use of early CMR imaging as a diagnostic tool in the investigation of patients with MINOCA. (Stockholm Myocardial Infarction With Normal Coronaries [SMINC]-2 Study on Diagnosis Made by Cardiac MRI [SCMINC-2]; NCT02318498)
[Display omitted]</description><identifier>ISSN: 1936-878X</identifier><identifier>EISSN: 1876-7591</identifier><identifier>DOI: 10.1016/j.jcmg.2021.02.021</identifier><identifier>PMID: 33865778</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>cardiac magnetic resonance ; myocardial infarction ; myocarditis ; nonobstructive coronary arteries ; takotsubo syndrome</subject><ispartof>JACC. Cardiovascular imaging, 2021-09, Vol.14 (9), p.1774-1783</ispartof><rights>2021 The Authors</rights><rights>Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c462t-435b2bc09e76be06fb674cc76c1c734619ef241d0652c4694885e6cdfcea237b3</citedby><cites>FETCH-LOGICAL-c462t-435b2bc09e76be06fb674cc76c1c734619ef241d0652c4694885e6cdfcea237b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1936878X21002023$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,3537,26544,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33865778$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:147678647$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Sörensson, Peder</creatorcontrib><creatorcontrib>Ekenbäck, Christina</creatorcontrib><creatorcontrib>Lundin, Magnus</creatorcontrib><creatorcontrib>Agewall, Stefan</creatorcontrib><creatorcontrib>Bacsovics Brolin, Elin</creatorcontrib><creatorcontrib>Caidahl, Kenneth</creatorcontrib><creatorcontrib>Cederlund, Kerstin</creatorcontrib><creatorcontrib>Collste, Olov</creatorcontrib><creatorcontrib>Daniel, Maria</creatorcontrib><creatorcontrib>Jensen, Jens</creatorcontrib><creatorcontrib>Y-Hassan, Shams</creatorcontrib><creatorcontrib>Henareh, Loghman</creatorcontrib><creatorcontrib>Hofman-Bang, Claes</creatorcontrib><creatorcontrib>Lyngå, Patrik</creatorcontrib><creatorcontrib>Maret, Eva</creatorcontrib><creatorcontrib>Sarkar, Nondita</creatorcontrib><creatorcontrib>Spaak, Jonas</creatorcontrib><creatorcontrib>Winnberg, Oscar</creatorcontrib><creatorcontrib>Ugander, Martin</creatorcontrib><creatorcontrib>Tornvall, Per</creatorcontrib><title>Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries</title><title>JACC. Cardiovascular imaging</title><addtitle>JACC Cardiovasc Imaging</addtitle><description>The objective of the SMINC-2 (Stockholm Myocardial Infarction With Normal Coronaries 2) study was to determine if more than 70% of patients with myocardial infarction with nonobstructed coronary arteries (MINOCA), investigated early with comprehensive cardiovascular magnetic resonance (CMR), could receive a diagnosis entirely by imaging.
The etiology of MINOCA is heterogeneous, including coronary, cardiac, and noncardiac causes. Patients with MINOCA, therefore, represent a diagnostic challenge where CMR is increasingly used.
The SMINC-2 study was a prospective study of 148 patients with MINOCA imaged with 1.5-T CMR with T1 and extracellular volume mapping early after hospital admission, compared to 150 patients with MINOCA imaged using 1.5-T CMR without mapping techniques from the SMINC-1 study as historic controls.
CMR was performed at a median of 3 (SMINC-2) versus 12 (SMINC-1) days after hospital admission. In total, 77% of patients received a diagnosis with CMR imaging in the SMINC-2 study compared to 47% in the SMINC-1 study (p < 0.001). Compared to SMINC-1, CMR in SMINC-2 detected higher proportions of myocarditis (17% vs. 7%; p = 0.01) and takotsubo syndrome (35% vs. 19%; p = 0.002) but similar proportions of myocardial infarction (22% vs. 19%; p = 0.56) and other cardiomyopathies (3% vs. 2%; p = 0.46).
The results of the SMINC-2 study show that 77% of all patients with MINOCA received a diagnosis when imaged early with CMR, including advanced tissue characterization, which was a considerable improvement in comparison to the SMINC-1 study. This supports the use of early CMR imaging as a diagnostic tool in the investigation of patients with MINOCA. (Stockholm Myocardial Infarction With Normal Coronaries [SMINC]-2 Study on Diagnosis Made by Cardiac MRI [SCMINC-2]; NCT02318498)
[Display omitted]</description><subject>cardiac magnetic resonance</subject><subject>myocardial infarction</subject><subject>myocarditis</subject><subject>nonobstructive coronary arteries</subject><subject>takotsubo syndrome</subject><issn>1936-878X</issn><issn>1876-7591</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><sourceid>D8T</sourceid><recordid>eNp9kc9u1DAQxiMEon_gBTiAj1yy2E5iJxKXalXKSi0gBIKb5UwmWy-JvdjOon0FnhpH2faINJKt8e_7ZuQvy14xumKUiXe71Q7G7YpTzlaUp2JPsnNWS5HLqmFP070pRF7L-udZdhHCjlJBRSmfZ2dFUYtKyvo8-3ut_XAkazfuPd6jDeaAZK19Z9xBB5gG7cmd3lqMBshXDM5qC0g2o94auyXGki86GrQxkB8m3pO7o4NZrQeysb32EI2zy9MnZ10bop9Sbx7ifDLzR3LlI3qD4UX2rNdDwJen8zL7_uH62_pjfvv5ZrO-us2hFDzmZVG1vAXaoBQtUtG3QpYAUgADWZSCNdjzknVUVDwpmrKuKxTQ9YCaF7ItLrN88Q1_cD-1au_NmPZQTht1av1KN1RpnGQ88W8WHrwJ0VhlndeK0briqimYbBLxdiH23v2eMEQ1mgA4DNqim4LiFavmdSqRUP5g5kLw2D-OZ1TNqaqdmlNVc6qK8lQsiV6f_Kd2xO5R8hBjAt4vAKZ_Oxj0KkAKBbAzHiGqzpn_-f8DPd-1jQ</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Sörensson, Peder</creator><creator>Ekenbäck, Christina</creator><creator>Lundin, Magnus</creator><creator>Agewall, Stefan</creator><creator>Bacsovics Brolin, Elin</creator><creator>Caidahl, Kenneth</creator><creator>Cederlund, Kerstin</creator><creator>Collste, Olov</creator><creator>Daniel, Maria</creator><creator>Jensen, Jens</creator><creator>Y-Hassan, Shams</creator><creator>Henareh, Loghman</creator><creator>Hofman-Bang, Claes</creator><creator>Lyngå, Patrik</creator><creator>Maret, Eva</creator><creator>Sarkar, Nondita</creator><creator>Spaak, Jonas</creator><creator>Winnberg, Oscar</creator><creator>Ugander, Martin</creator><creator>Tornvall, Per</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>3HK</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20210901</creationdate><title>Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries</title><author>Sörensson, Peder ; Ekenbäck, Christina ; Lundin, Magnus ; Agewall, Stefan ; Bacsovics Brolin, Elin ; Caidahl, Kenneth ; Cederlund, Kerstin ; Collste, Olov ; Daniel, Maria ; Jensen, Jens ; Y-Hassan, Shams ; Henareh, Loghman ; Hofman-Bang, Claes ; Lyngå, Patrik ; Maret, Eva ; Sarkar, Nondita ; Spaak, Jonas ; Winnberg, Oscar ; Ugander, Martin ; Tornvall, Per</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c462t-435b2bc09e76be06fb674cc76c1c734619ef241d0652c4694885e6cdfcea237b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>cardiac magnetic resonance</topic><topic>myocardial infarction</topic><topic>myocarditis</topic><topic>nonobstructive coronary arteries</topic><topic>takotsubo syndrome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sörensson, Peder</creatorcontrib><creatorcontrib>Ekenbäck, Christina</creatorcontrib><creatorcontrib>Lundin, Magnus</creatorcontrib><creatorcontrib>Agewall, Stefan</creatorcontrib><creatorcontrib>Bacsovics Brolin, Elin</creatorcontrib><creatorcontrib>Caidahl, Kenneth</creatorcontrib><creatorcontrib>Cederlund, Kerstin</creatorcontrib><creatorcontrib>Collste, Olov</creatorcontrib><creatorcontrib>Daniel, Maria</creatorcontrib><creatorcontrib>Jensen, Jens</creatorcontrib><creatorcontrib>Y-Hassan, Shams</creatorcontrib><creatorcontrib>Henareh, Loghman</creatorcontrib><creatorcontrib>Hofman-Bang, Claes</creatorcontrib><creatorcontrib>Lyngå, Patrik</creatorcontrib><creatorcontrib>Maret, Eva</creatorcontrib><creatorcontrib>Sarkar, Nondita</creatorcontrib><creatorcontrib>Spaak, Jonas</creatorcontrib><creatorcontrib>Winnberg, Oscar</creatorcontrib><creatorcontrib>Ugander, Martin</creatorcontrib><creatorcontrib>Tornvall, Per</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>JACC. Cardiovascular imaging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sörensson, Peder</au><au>Ekenbäck, Christina</au><au>Lundin, Magnus</au><au>Agewall, Stefan</au><au>Bacsovics Brolin, Elin</au><au>Caidahl, Kenneth</au><au>Cederlund, Kerstin</au><au>Collste, Olov</au><au>Daniel, Maria</au><au>Jensen, Jens</au><au>Y-Hassan, Shams</au><au>Henareh, Loghman</au><au>Hofman-Bang, Claes</au><au>Lyngå, Patrik</au><au>Maret, Eva</au><au>Sarkar, Nondita</au><au>Spaak, Jonas</au><au>Winnberg, Oscar</au><au>Ugander, Martin</au><au>Tornvall, Per</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries</atitle><jtitle>JACC. Cardiovascular imaging</jtitle><addtitle>JACC Cardiovasc Imaging</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>14</volume><issue>9</issue><spage>1774</spage><epage>1783</epage><pages>1774-1783</pages><issn>1936-878X</issn><eissn>1876-7591</eissn><abstract>The objective of the SMINC-2 (Stockholm Myocardial Infarction With Normal Coronaries 2) study was to determine if more than 70% of patients with myocardial infarction with nonobstructed coronary arteries (MINOCA), investigated early with comprehensive cardiovascular magnetic resonance (CMR), could receive a diagnosis entirely by imaging.
The etiology of MINOCA is heterogeneous, including coronary, cardiac, and noncardiac causes. Patients with MINOCA, therefore, represent a diagnostic challenge where CMR is increasingly used.
The SMINC-2 study was a prospective study of 148 patients with MINOCA imaged with 1.5-T CMR with T1 and extracellular volume mapping early after hospital admission, compared to 150 patients with MINOCA imaged using 1.5-T CMR without mapping techniques from the SMINC-1 study as historic controls.
CMR was performed at a median of 3 (SMINC-2) versus 12 (SMINC-1) days after hospital admission. In total, 77% of patients received a diagnosis with CMR imaging in the SMINC-2 study compared to 47% in the SMINC-1 study (p < 0.001). Compared to SMINC-1, CMR in SMINC-2 detected higher proportions of myocarditis (17% vs. 7%; p = 0.01) and takotsubo syndrome (35% vs. 19%; p = 0.002) but similar proportions of myocardial infarction (22% vs. 19%; p = 0.56) and other cardiomyopathies (3% vs. 2%; p = 0.46).
The results of the SMINC-2 study show that 77% of all patients with MINOCA received a diagnosis when imaged early with CMR, including advanced tissue characterization, which was a considerable improvement in comparison to the SMINC-1 study. This supports the use of early CMR imaging as a diagnostic tool in the investigation of patients with MINOCA. (Stockholm Myocardial Infarction With Normal Coronaries [SMINC]-2 Study on Diagnosis Made by Cardiac MRI [SCMINC-2]; NCT02318498)
[Display omitted]</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>33865778</pmid><doi>10.1016/j.jcmg.2021.02.021</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
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| ispartof | JACC. Cardiovascular imaging, 2021-09, Vol.14 (9), p.1774-1783 |
| issn | 1936-878X 1876-7591 |
| language | eng |
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| source | NORA - Norwegian Open Research Archives; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; SWEPUB Freely available online |
| subjects | cardiac magnetic resonance myocardial infarction myocarditis nonobstructive coronary arteries takotsubo syndrome |
| title | Early Comprehensive Cardiovascular Magnetic Resonance Imaging in Patients With Myocardial Infarction With Nonobstructive Coronary Arteries |
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