FGL1 as a modulator of plasma D‐dimer levels: Exome‐wide marker analysis of plasma tPA, PAI‐1, and D‐dimer

Background Use of targeted exome‐arrays with common, rare variants and functionally enriched variation has led to discovery of new genes contributing to population variation in risk factors. Plasminogen activator‐inhibitor 1 (PAI‐1), tissue plasminogen activator (tPA), and the plasma product D‐dimer...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2021-08, Vol.19 (8), p.2019-2028
Hauptverfasser:	Thibord, Florian, Song, Ci, Pattee, Jack, Rodriguez, Benjamin A.T., Chen, Ming‐Huei, O’Donnell, Christopher J., Kleber, Marcus E., Delgado, Graciela E., Guo, Xiuqing, Yao, Jie, Taylor, Kent D., Ozel, Ayse Bilge, Brody, Jennifer A., McKnight, Barbara, Gyorgy, Beata, Simonsick, Eleanor, Leonard, Hampton L., Carrasquilla, Germán D., Guindo‐Martinez, Marta, Silveira, Angela, Temprano‐Sagrera, Gerard, Yanek, Lisa R., Becker, Diane M., Mathias, Rasika A., Becker, Lewis C., Raffield, Laura M., Kilpeläinen, Tuomas O., Grarup, Niels, Pedersen, Oluf, Hansen, Torben, Linneberg, Allan, Hamsten, Anders, Watkins, Hugh, Sabater‐Lleal, Maria, Nalls, Mike A., Trégouët, David‐Alexandre, Morange, Pierre‐Emmanuel, Psaty, Bruce M., Tracy, Russel P., Smith, Nicholas L., Desch, Karl C., Cushman, Mary, Rotter, Jerome I., Vries, Paul S., Pankratz, Nathan D., Folsom, Aaron R., Morrison, Alanna C., März, Winfried, Tang, Weihong, Johnson, Andrew D.
Format:	Artikel
Sprache:	eng
Schlagworte:	computational biology Exome Fibrin Fibrin Fibrinogen Degradation Products Fibrinogen Fibrinogen - genetics Fibrinolysis Gene frequency genetic association study Genetic diversity Genomes Hemostasis Humans Life Sciences Plasma Plasminogen Activator Inhibitor 1 - genetics Replication Risk factors Santé publique et épidémiologie t-Plasminogen activator Thrombolytic drugs Tissue Plasminogen Activator - genetics
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