The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland

Objective Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods Using the SomaScan platform, we measured 4,792 proteins in...

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Veröffentlicht in:	Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2021-11, Vol.73 (11), p.2025-2034
Hauptverfasser:	Styrkarsdottir, Unnur, Lund, Sigrun H., Saevarsdottir, Saedis, Magnusson, Magnus I., Gunnarsdottir, Kristbjorg, Norddahl, Gudmundur L., Frigge, Michael L., Ivarsdottir, Erna V., Bjornsdottir, Gyda, Holm, Hilma, Thorgeirsson, Gudmundur, Rafnar, Thorunn, Jonsdottir, Ingileif, Ingvarsson, Thorvaldur, Jonsson, Helgi, Sulem, Patrick, Thorsteinsdottir, Unnur, Gudbjartsson, Daniel, Stefansson, Kari
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Arthritis Arthroplasty, Replacement Biomarkers Biomarkers - blood Biomedical materials Body mass Body mass index Body size Calcium-Binding Proteins - blood Cartilage Cartilage diseases Case-Control Studies Confidence intervals Diagnosis Disease Progression Female Full Length Hip Humans Iceland Inflammation Joints (anatomy) Knee Male Middle Aged Orthopaedic implants Osteoarthritis Osteoarthritis - blood Osteoarthritis - diagnosis Osteoarthritis - surgery Patients Plasma Plasma proteins Prospective Studies Proteins Proteomics Risk analysis Risk factors
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