The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland
Objective Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement. Methods Using the SomaScan platform, we measured 4,792 proteins in...
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| Veröffentlicht in: | Arthritis & rheumatology (Hoboken, N.J.) N.J.), 2021-11, Vol.73 (11), p.2025-2034 |
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| creator | Styrkarsdottir, Unnur Lund, Sigrun H. Saevarsdottir, Saedis Magnusson, Magnus I. Gunnarsdottir, Kristbjorg Norddahl, Gudmundur L. Frigge, Michael L. Ivarsdottir, Erna V. Bjornsdottir, Gyda Holm, Hilma Thorgeirsson, Gudmundur Rafnar, Thorunn Jonsdottir, Ingileif Ingvarsson, Thorvaldur Jonsson, Helgi Sulem, Patrick Thorsteinsdottir, Unnur Gudbjartsson, Daniel Stefansson, Kari |
| description | Objective
Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.
Methods
Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case–control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.
Results
Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95% confidence interval 1.41–1.52] for knee OA, odds ratio 1.36 [95% confidence interval 1.29–1.43] for hip OA, and odds ratio 1.33 [95% confidence interval 1.26–1.40] for hand OA) and progression to joint replacement (hazard ratio 1.40 [95% confidence interval 1.30–1.51] for knee replacement and hazard ratio 1.31 [95% confidence interval 1.19–1.45] for hip replacement). Patients with OA who were in the highest quintile of risk of joint replacement, based on known risk factors (i.e., age, sex, and body mass index) and plasma CRTAC1 level, were 16 times more likely to undergo knee replacement within 5 years of plasma sample collection than those in the lowest quintile, and 6.5 times more likely to undergo hip replacement. CRTAC1 was not associated with other types of inflammatory arthritis. A specific protein profile was identified in those patients who had undergone joint replacement prior to plasma sample collection.
Conclusion
Through a hypothesis‐free approach, we identified CRTAC1 in plasma as a novel promising candidate biomarker for OA that is both associated with occurrence of OA and predictive of progression to joint replacement. This biomarker might also be useful in the selection of suitable patients for clinical trial enrollment. |
| doi_str_mv | 10.1002/art.41793 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_462050</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2592331342</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4813-1604769d87363b4820dc78251a9c70bf79206ee5b65938ffdd7cd53541c5d4413</originalsourceid><addsrcrecordid>eNp1ks1uEzEQx1cIRKvQAy-ALHGBQ1p_rL1rDkhRxEdQpFYhiKPleCeJy-66tR2q3ngEjjwfT8K0m1YUCcuSR_Zv_uO_PUXxnNFjRik_sTEfl6zS4lFxyAVXY8mpfHwXM80OiqOUzikOXVFF5dPiQAhd81qLw-LXcgtkulhOpoycxZDB9wTnWWtTZ8kskUlKwXmboSFffd6S05QhYM1t9NknYvsG86DxLqcbgU2ElHzoSQ7kU_B9Jgu4aK2DDvr8hkzI3MYN_P7x87OzLQwlQ-ddIrhxW3rmoEXVZ8WTtW0THO3XUfHl_bvl9ON4fvphNp3Mx66smRgzRctK6aauhBKrsua0cVXNJbPaVXS1rjSnCkCulNSiXq-bpnKNFLJkTjZlycSoGA-66QouditzEX1n47UJ1pv91jeMwJQK35Ui_3bg8aSDxqGtaNsHaQ9Per81m_Dd1FIrrSsUeLUXiOFyBymbzif0jKYh7JLhkitBlUY_o-LlP-h52MUenwMpzYVgouRIvR4oF0NKEdb3l2HU3LSIwe8yty2C7Iu_b39P3jUEAicDcOVbuP6_kpksloPkH8tOxyE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2592331342</pqid></control><display><type>article</type><title>The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><creator>Styrkarsdottir, Unnur ; Lund, Sigrun H. ; Saevarsdottir, Saedis ; Magnusson, Magnus I. ; Gunnarsdottir, Kristbjorg ; Norddahl, Gudmundur L. ; Frigge, Michael L. ; Ivarsdottir, Erna V. ; Bjornsdottir, Gyda ; Holm, Hilma ; Thorgeirsson, Gudmundur ; Rafnar, Thorunn ; Jonsdottir, Ingileif ; Ingvarsson, Thorvaldur ; Jonsson, Helgi ; Sulem, Patrick ; Thorsteinsdottir, Unnur ; Gudbjartsson, Daniel ; Stefansson, Kari</creator><creatorcontrib>Styrkarsdottir, Unnur ; Lund, Sigrun H. ; Saevarsdottir, Saedis ; Magnusson, Magnus I. ; Gunnarsdottir, Kristbjorg ; Norddahl, Gudmundur L. ; Frigge, Michael L. ; Ivarsdottir, Erna V. ; Bjornsdottir, Gyda ; Holm, Hilma ; Thorgeirsson, Gudmundur ; Rafnar, Thorunn ; Jonsdottir, Ingileif ; Ingvarsson, Thorvaldur ; Jonsson, Helgi ; Sulem, Patrick ; Thorsteinsdottir, Unnur ; Gudbjartsson, Daniel ; Stefansson, Kari</creatorcontrib><description>Objective
Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.
Methods
Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case–control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.
Results
Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95% confidence interval 1.41–1.52] for knee OA, odds ratio 1.36 [95% confidence interval 1.29–1.43] for hip OA, and odds ratio 1.33 [95% confidence interval 1.26–1.40] for hand OA) and progression to joint replacement (hazard ratio 1.40 [95% confidence interval 1.30–1.51] for knee replacement and hazard ratio 1.31 [95% confidence interval 1.19–1.45] for hip replacement). Patients with OA who were in the highest quintile of risk of joint replacement, based on known risk factors (i.e., age, sex, and body mass index) and plasma CRTAC1 level, were 16 times more likely to undergo knee replacement within 5 years of plasma sample collection than those in the lowest quintile, and 6.5 times more likely to undergo hip replacement. CRTAC1 was not associated with other types of inflammatory arthritis. A specific protein profile was identified in those patients who had undergone joint replacement prior to plasma sample collection.
Conclusion
Through a hypothesis‐free approach, we identified CRTAC1 in plasma as a novel promising candidate biomarker for OA that is both associated with occurrence of OA and predictive of progression to joint replacement. This biomarker might also be useful in the selection of suitable patients for clinical trial enrollment.</description><identifier>ISSN: 2326-5191</identifier><identifier>EISSN: 2326-5205</identifier><identifier>DOI: 10.1002/art.41793</identifier><identifier>PMID: 33982893</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Aged ; Arthritis ; Arthroplasty, Replacement ; Biomarkers ; Biomarkers - blood ; Biomedical materials ; Body mass ; Body mass index ; Body size ; Calcium-Binding Proteins - blood ; Cartilage ; Cartilage diseases ; Case-Control Studies ; Confidence intervals ; Diagnosis ; Disease Progression ; Female ; Full Length ; Hip ; Humans ; Iceland ; Inflammation ; Joints (anatomy) ; Knee ; Male ; Middle Aged ; Orthopaedic implants ; Osteoarthritis ; Osteoarthritis - blood ; Osteoarthritis - diagnosis ; Osteoarthritis - surgery ; Patients ; Plasma ; Plasma proteins ; Prospective Studies ; Proteins ; Proteomics ; Risk analysis ; Risk factors</subject><ispartof>Arthritis & rheumatology (Hoboken, N.J.), 2021-11, Vol.73 (11), p.2025-2034</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of American College of Rheumatology.</rights><rights>2021 The Authors. Arthritis & Rheumatology published by Wiley Periodicals LLC on behalf of American College of Rheumatology.</rights><rights>2021. This article is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4813-1604769d87363b4820dc78251a9c70bf79206ee5b65938ffdd7cd53541c5d4413</citedby><cites>FETCH-LOGICAL-c4813-1604769d87363b4820dc78251a9c70bf79206ee5b65938ffdd7cd53541c5d4413</cites><orcidid>0000-0001-8146-8278 ; 0000-0003-1676-864X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fart.41793$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fart.41793$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33982893$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:147724111$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Styrkarsdottir, Unnur</creatorcontrib><creatorcontrib>Lund, Sigrun H.</creatorcontrib><creatorcontrib>Saevarsdottir, Saedis</creatorcontrib><creatorcontrib>Magnusson, Magnus I.</creatorcontrib><creatorcontrib>Gunnarsdottir, Kristbjorg</creatorcontrib><creatorcontrib>Norddahl, Gudmundur L.</creatorcontrib><creatorcontrib>Frigge, Michael L.</creatorcontrib><creatorcontrib>Ivarsdottir, Erna V.</creatorcontrib><creatorcontrib>Bjornsdottir, Gyda</creatorcontrib><creatorcontrib>Holm, Hilma</creatorcontrib><creatorcontrib>Thorgeirsson, Gudmundur</creatorcontrib><creatorcontrib>Rafnar, Thorunn</creatorcontrib><creatorcontrib>Jonsdottir, Ingileif</creatorcontrib><creatorcontrib>Ingvarsson, Thorvaldur</creatorcontrib><creatorcontrib>Jonsson, Helgi</creatorcontrib><creatorcontrib>Sulem, Patrick</creatorcontrib><creatorcontrib>Thorsteinsdottir, Unnur</creatorcontrib><creatorcontrib>Gudbjartsson, Daniel</creatorcontrib><creatorcontrib>Stefansson, Kari</creatorcontrib><title>The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland</title><title>Arthritis & rheumatology (Hoboken, N.J.)</title><addtitle>Arthritis Rheumatol</addtitle><description>Objective
Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.
Methods
Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case–control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.
Results
Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95% confidence interval 1.41–1.52] for knee OA, odds ratio 1.36 [95% confidence interval 1.29–1.43] for hip OA, and odds ratio 1.33 [95% confidence interval 1.26–1.40] for hand OA) and progression to joint replacement (hazard ratio 1.40 [95% confidence interval 1.30–1.51] for knee replacement and hazard ratio 1.31 [95% confidence interval 1.19–1.45] for hip replacement). Patients with OA who were in the highest quintile of risk of joint replacement, based on known risk factors (i.e., age, sex, and body mass index) and plasma CRTAC1 level, were 16 times more likely to undergo knee replacement within 5 years of plasma sample collection than those in the lowest quintile, and 6.5 times more likely to undergo hip replacement. CRTAC1 was not associated with other types of inflammatory arthritis. A specific protein profile was identified in those patients who had undergone joint replacement prior to plasma sample collection.
Conclusion
Through a hypothesis‐free approach, we identified CRTAC1 in plasma as a novel promising candidate biomarker for OA that is both associated with occurrence of OA and predictive of progression to joint replacement. This biomarker might also be useful in the selection of suitable patients for clinical trial enrollment.</description><subject>Adult</subject><subject>Aged</subject><subject>Arthritis</subject><subject>Arthroplasty, Replacement</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Biomedical materials</subject><subject>Body mass</subject><subject>Body mass index</subject><subject>Body size</subject><subject>Calcium-Binding Proteins - blood</subject><subject>Cartilage</subject><subject>Cartilage diseases</subject><subject>Case-Control Studies</subject><subject>Confidence intervals</subject><subject>Diagnosis</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Full Length</subject><subject>Hip</subject><subject>Humans</subject><subject>Iceland</subject><subject>Inflammation</subject><subject>Joints (anatomy)</subject><subject>Knee</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Orthopaedic implants</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - blood</subject><subject>Osteoarthritis - diagnosis</subject><subject>Osteoarthritis - surgery</subject><subject>Patients</subject><subject>Plasma</subject><subject>Plasma proteins</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Proteomics</subject><subject>Risk analysis</subject><subject>Risk factors</subject><issn>2326-5191</issn><issn>2326-5205</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp1ks1uEzEQx1cIRKvQAy-ALHGBQ1p_rL1rDkhRxEdQpFYhiKPleCeJy-66tR2q3ngEjjwfT8K0m1YUCcuSR_Zv_uO_PUXxnNFjRik_sTEfl6zS4lFxyAVXY8mpfHwXM80OiqOUzikOXVFF5dPiQAhd81qLw-LXcgtkulhOpoycxZDB9wTnWWtTZ8kskUlKwXmboSFffd6S05QhYM1t9NknYvsG86DxLqcbgU2ElHzoSQ7kU_B9Jgu4aK2DDvr8hkzI3MYN_P7x87OzLQwlQ-ddIrhxW3rmoEXVZ8WTtW0THO3XUfHl_bvl9ON4fvphNp3Mx66smRgzRctK6aauhBKrsua0cVXNJbPaVXS1rjSnCkCulNSiXq-bpnKNFLJkTjZlycSoGA-66QouditzEX1n47UJ1pv91jeMwJQK35Ui_3bg8aSDxqGtaNsHaQ9Per81m_Dd1FIrrSsUeLUXiOFyBymbzif0jKYh7JLhkitBlUY_o-LlP-h52MUenwMpzYVgouRIvR4oF0NKEdb3l2HU3LSIwe8yty2C7Iu_b39P3jUEAicDcOVbuP6_kpksloPkH8tOxyE</recordid><startdate>202111</startdate><enddate>202111</enddate><creator>Styrkarsdottir, Unnur</creator><creator>Lund, Sigrun H.</creator><creator>Saevarsdottir, Saedis</creator><creator>Magnusson, Magnus I.</creator><creator>Gunnarsdottir, Kristbjorg</creator><creator>Norddahl, Gudmundur L.</creator><creator>Frigge, Michael L.</creator><creator>Ivarsdottir, Erna V.</creator><creator>Bjornsdottir, Gyda</creator><creator>Holm, Hilma</creator><creator>Thorgeirsson, Gudmundur</creator><creator>Rafnar, Thorunn</creator><creator>Jonsdottir, Ingileif</creator><creator>Ingvarsson, Thorvaldur</creator><creator>Jonsson, Helgi</creator><creator>Sulem, Patrick</creator><creator>Thorsteinsdottir, Unnur</creator><creator>Gudbjartsson, Daniel</creator><creator>Stefansson, Kari</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TM</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0001-8146-8278</orcidid><orcidid>https://orcid.org/0000-0003-1676-864X</orcidid></search><sort><creationdate>202111</creationdate><title>The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland</title><author>Styrkarsdottir, Unnur ; Lund, Sigrun H. ; Saevarsdottir, Saedis ; Magnusson, Magnus I. ; Gunnarsdottir, Kristbjorg ; Norddahl, Gudmundur L. ; Frigge, Michael L. ; Ivarsdottir, Erna V. ; Bjornsdottir, Gyda ; Holm, Hilma ; Thorgeirsson, Gudmundur ; Rafnar, Thorunn ; Jonsdottir, Ingileif ; Ingvarsson, Thorvaldur ; Jonsson, Helgi ; Sulem, Patrick ; Thorsteinsdottir, Unnur ; Gudbjartsson, Daniel ; Stefansson, Kari</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4813-1604769d87363b4820dc78251a9c70bf79206ee5b65938ffdd7cd53541c5d4413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Arthritis</topic><topic>Arthroplasty, Replacement</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Biomedical materials</topic><topic>Body mass</topic><topic>Body mass index</topic><topic>Body size</topic><topic>Calcium-Binding Proteins - blood</topic><topic>Cartilage</topic><topic>Cartilage diseases</topic><topic>Case-Control Studies</topic><topic>Confidence intervals</topic><topic>Diagnosis</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Full Length</topic><topic>Hip</topic><topic>Humans</topic><topic>Iceland</topic><topic>Inflammation</topic><topic>Joints (anatomy)</topic><topic>Knee</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Orthopaedic implants</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - blood</topic><topic>Osteoarthritis - diagnosis</topic><topic>Osteoarthritis - surgery</topic><topic>Patients</topic><topic>Plasma</topic><topic>Plasma proteins</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Proteomics</topic><topic>Risk analysis</topic><topic>Risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Styrkarsdottir, Unnur</creatorcontrib><creatorcontrib>Lund, Sigrun H.</creatorcontrib><creatorcontrib>Saevarsdottir, Saedis</creatorcontrib><creatorcontrib>Magnusson, Magnus I.</creatorcontrib><creatorcontrib>Gunnarsdottir, Kristbjorg</creatorcontrib><creatorcontrib>Norddahl, Gudmundur L.</creatorcontrib><creatorcontrib>Frigge, Michael L.</creatorcontrib><creatorcontrib>Ivarsdottir, Erna V.</creatorcontrib><creatorcontrib>Bjornsdottir, Gyda</creatorcontrib><creatorcontrib>Holm, Hilma</creatorcontrib><creatorcontrib>Thorgeirsson, Gudmundur</creatorcontrib><creatorcontrib>Rafnar, Thorunn</creatorcontrib><creatorcontrib>Jonsdottir, Ingileif</creatorcontrib><creatorcontrib>Ingvarsson, Thorvaldur</creatorcontrib><creatorcontrib>Jonsson, Helgi</creatorcontrib><creatorcontrib>Sulem, Patrick</creatorcontrib><creatorcontrib>Thorsteinsdottir, Unnur</creatorcontrib><creatorcontrib>Gudbjartsson, Daniel</creatorcontrib><creatorcontrib>Stefansson, Kari</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Styrkarsdottir, Unnur</au><au>Lund, Sigrun H.</au><au>Saevarsdottir, Saedis</au><au>Magnusson, Magnus I.</au><au>Gunnarsdottir, Kristbjorg</au><au>Norddahl, Gudmundur L.</au><au>Frigge, Michael L.</au><au>Ivarsdottir, Erna V.</au><au>Bjornsdottir, Gyda</au><au>Holm, Hilma</au><au>Thorgeirsson, Gudmundur</au><au>Rafnar, Thorunn</au><au>Jonsdottir, Ingileif</au><au>Ingvarsson, Thorvaldur</au><au>Jonsson, Helgi</au><au>Sulem, Patrick</au><au>Thorsteinsdottir, Unnur</au><au>Gudbjartsson, Daniel</au><au>Stefansson, Kari</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland</atitle><jtitle>Arthritis & rheumatology (Hoboken, N.J.)</jtitle><addtitle>Arthritis Rheumatol</addtitle><date>2021-11</date><risdate>2021</risdate><volume>73</volume><issue>11</issue><spage>2025</spage><epage>2034</epage><pages>2025-2034</pages><issn>2326-5191</issn><eissn>2326-5205</eissn><abstract>Objective
Biomarkers for diagnosis and progression of osteoarthritis (OA) are lacking. This study was undertaken to identify circulating biomarkers for OA that could predict disease occurrence and/or progression to joint replacement.
Methods
Using the SomaScan platform, we measured 4,792 proteins in plasma from 37,278 individuals, of whom 12,178 individuals had OA and 2,524 had undergone joint replacement. We performed a case–control study for identification of potential protein biomarkers for hip, knee, and/or hand OA, and a prospective study for identification of biomarkers for joint replacement.
Results
Among the large panel of plasma proteins assessed, cartilage acidic protein 1 (CRTAC1) was the most strongly associated with both OA diagnosis (odds ratio 1.46 [95% confidence interval 1.41–1.52] for knee OA, odds ratio 1.36 [95% confidence interval 1.29–1.43] for hip OA, and odds ratio 1.33 [95% confidence interval 1.26–1.40] for hand OA) and progression to joint replacement (hazard ratio 1.40 [95% confidence interval 1.30–1.51] for knee replacement and hazard ratio 1.31 [95% confidence interval 1.19–1.45] for hip replacement). Patients with OA who were in the highest quintile of risk of joint replacement, based on known risk factors (i.e., age, sex, and body mass index) and plasma CRTAC1 level, were 16 times more likely to undergo knee replacement within 5 years of plasma sample collection than those in the lowest quintile, and 6.5 times more likely to undergo hip replacement. CRTAC1 was not associated with other types of inflammatory arthritis. A specific protein profile was identified in those patients who had undergone joint replacement prior to plasma sample collection.
Conclusion
Through a hypothesis‐free approach, we identified CRTAC1 in plasma as a novel promising candidate biomarker for OA that is both associated with occurrence of OA and predictive of progression to joint replacement. This biomarker might also be useful in the selection of suitable patients for clinical trial enrollment.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>33982893</pmid><doi>10.1002/art.41793</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-8146-8278</orcidid><orcidid>https://orcid.org/0000-0003-1676-864X</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2326-5191 |
| ispartof | Arthritis & rheumatology (Hoboken, N.J.), 2021-11, Vol.73 (11), p.2025-2034 |
| issn | 2326-5191 2326-5205 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection; SWEPUB Freely available online |
| subjects | Adult Aged Arthritis Arthroplasty, Replacement Biomarkers Biomarkers - blood Biomedical materials Body mass Body mass index Body size Calcium-Binding Proteins - blood Cartilage Cartilage diseases Case-Control Studies Confidence intervals Diagnosis Disease Progression Female Full Length Hip Humans Iceland Inflammation Joints (anatomy) Knee Male Middle Aged Orthopaedic implants Osteoarthritis Osteoarthritis - blood Osteoarthritis - diagnosis Osteoarthritis - surgery Patients Plasma Plasma proteins Prospective Studies Proteins Proteomics Risk analysis Risk factors |
| title | The CRTAC1 Protein in Plasma Is Associated With Osteoarthritis and Predicts Progression to Joint Replacement: A Large‐Scale Proteomics Scan in Iceland |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T00%3A01%3A56IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20CRTAC1%20Protein%20in%20Plasma%20Is%20Associated%20With%20Osteoarthritis%20and%20Predicts%20Progression%20to%20Joint%20Replacement:%20A%20Large%E2%80%90Scale%20Proteomics%20Scan%20in%20Iceland&rft.jtitle=Arthritis%20&%20rheumatology%20(Hoboken,%20N.J.)&rft.au=Styrkarsdottir,%20Unnur&rft.date=2021-11&rft.volume=73&rft.issue=11&rft.spage=2025&rft.epage=2034&rft.pages=2025-2034&rft.issn=2326-5191&rft.eissn=2326-5205&rft_id=info:doi/10.1002/art.41793&rft_dat=%3Cproquest_swepu%3E2592331342%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2592331342&rft_id=info:pmid/33982893&rfr_iscdi=true |