GABAergic signaling in human and murine NK cells upon challenge with Toxoplasma gondii

Protective cytotoxic and proinflammatory cytokine responses by NK cells impact the outcome of infections by Toxoplasma gondii, a common parasite in humans and other vertebrates. However, T. gondii can also sequester within NK cells and downmodulate their effector functions. Recently, the implication...

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Veröffentlicht in:	Journal of leukocyte biology 2021-10, Vol.110 (4), p.617-628
Hauptverfasser:	Bhandage, Amol K., Friedrich, Laura M., Kanatani, Sachie, Jakobsson‐Björkén, Simon, Escrig‐Larena, J. Ignacio, Wagner, Arnika K., Chambers, Benedict J., Barragan, Antonio
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apicomplexa Cell Death Cell Degranulation - physiology Cell Line cell migration Cell Movement Dendritic Cells - parasitology GABA-A receptor GABA-Areceptor gamma-Aminobutyric Acid - metabolism Host-pathogen Humans immunomodulation Killer Cells, Natural - metabolism Killer Cells, Natural - parasitology Killer Cells, Natural - physiology Lymphocyte Mice Mice, Inbred C57BL neurotransmitter Signal Transduction Toxoplasma - physiology Transcription, Genetic
Online-Zugang:	Volltext
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