Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations
Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease...
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| Veröffentlicht in: | Bone marrow transplantation (Basingstoke) 2021-07, Vol.56 (7), p.1493-1508 |
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| creator | Greco, Raffaella Alexander, Tobias Burman, Joachim Del Papa, Nicoletta de Vries-Bouwstra, Jeska Farge, Dominique Henes, Jörg Kazmi, Majid Kirgizov, Kirill Muraro, Paolo A. Ricart, Elena Rovira, Montserrat Saccardi, Riccardo Sharrack, Basil Snarski, Emilian Withers, Barbara Jessop, Helen Boglione, Claudia Kramer, Ellen Badoglio, Manuela Labopin, Myriam Orchard, Kim Corbacioglu, Selim Ljungman, Per Mikulska, Malgorzata De la Camara, Rafael Snowden, John A. |
| description | Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an “endemic” phase and therefore an ongoing risk within a “new normality”. These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice. |
| doi_str_mv | 10.1038/s41409-021-01326-6 |
| format | Article |
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Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an “endemic” phase and therefore an ongoing risk within a “new normality”. 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Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SWEPUB Uppsala universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Uppsala universitet</collection><collection>SwePub Articles full text</collection><jtitle>Bone marrow transplantation (Basingstoke)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Greco, Raffaella</au><au>Alexander, Tobias</au><au>Burman, Joachim</au><au>Del Papa, Nicoletta</au><au>de Vries-Bouwstra, Jeska</au><au>Farge, Dominique</au><au>Henes, Jörg</au><au>Kazmi, Majid</au><au>Kirgizov, Kirill</au><au>Muraro, Paolo A.</au><au>Ricart, Elena</au><au>Rovira, Montserrat</au><au>Saccardi, Riccardo</au><au>Sharrack, Basil</au><au>Snarski, Emilian</au><au>Withers, Barbara</au><au>Jessop, Helen</au><au>Boglione, Claudia</au><au>Kramer, Ellen</au><au>Badoglio, Manuela</au><au>Labopin, Myriam</au><au>Orchard, Kim</au><au>Corbacioglu, Selim</au><au>Ljungman, Per</au><au>Mikulska, Malgorzata</au><au>De la Camara, Rafael</au><au>Snowden, John A.</au><aucorp>European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP), Infectious Diseases Working Party (IDWP), Pediatric Working Party (PWP), Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE), EBMT Nurses Group and Patient Advocacy Committee</aucorp><aucorp>On behalf of the European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP), Infectious Diseases Working Party (IDWP), Pediatric Working Party (PWP), Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE), EBMT Nurses Group and Patient Advocacy Committee</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations</atitle><jtitle>Bone marrow transplantation (Basingstoke)</jtitle><stitle>Bone Marrow Transplant</stitle><addtitle>Bone Marrow Transplant</addtitle><date>2021-07-01</date><risdate>2021</risdate><volume>56</volume><issue>7</issue><spage>1493</spage><epage>1508</epage><pages>1493-1508</pages><issn>0268-3369</issn><issn>1476-5365</issn><eissn>1476-5365</eissn><abstract>Coronavirus disease-19 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), represents one of the biggest challenges of 21st century, threatening public health around the globe. Increasing age and presence of co-morbidities are reported risk factors for severe disease and mortality, along with autoimmune diseases (ADs) and immunosuppressive treatments such as haematopoietic stem cell transplantation (HSCT), which are also associated with adverse outcomes. We review the impact of the pandemic on specific groups of patients with neurological, rheumatological, and gastroenterological indications, along with the challenges delivering HSCT in adult and pediatric populations. Moving forward, we developed consensus-based guidelines and recommendations for best practice and quality of patient care in order to support clinicians, scientists, and their multidisciplinary teams, as well as patients and their carers. These guidelines aim to support national and international organizations related to autoimmune diseases and local clinical teams delivering HSCT. Areas of unmet need and future research questions are also highlighted. The waves of the COVID-19 pandemic are predicted to be followed by an “endemic” phase and therefore an ongoing risk within a “new normality”. These recommendations reflect currently available evidence, coupled with expert opinion, and will be revised according to necessary modifications in practice.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34031556</pmid><doi>10.1038/s41409-021-01326-6</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-4514-4748</orcidid><orcidid>https://orcid.org/0000-0003-3226-2024</orcidid><orcidid>https://orcid.org/0000-0002-8189-5779</orcidid><orcidid>https://orcid.org/0000-0003-2700-7571</orcidid><orcidid>https://orcid.org/0000-0001-6819-3476</orcidid><orcidid>https://orcid.org/0000-0002-3822-1218</orcidid><orcidid>https://orcid.org/0000-0002-7045-1806</orcidid><orcidid>https://orcid.org/0000-0002-8281-3245</orcidid><orcidid>https://orcid.org/0000-0003-1193-0097</orcidid><orcidid>https://orcid.org/0000-0002-6117-5328</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0268-3369 |
| ispartof | Bone marrow transplantation (Basingstoke), 2021-07, Vol.56 (7), p.1493-1508 |
| issn | 0268-3369 1476-5365 1476-5365 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_461787 |
| source | MEDLINE; SpringerLink Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online |
| subjects | 692/699/1503/257 692/699/1670 692/699/255 692/699/375 692/700/565/251 Adult Autoimmune diseases Autoimmune Diseases - therapy Best practice Bone marrow Care and treatment Cell Biology Child Control Coronaviruses COVID-19 Epidemics Europe Feature Guidelines Health risks Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Internal Medicine International organizations Medicine Medicine & Public Health Pandemics Patients Public Health Respiratory diseases Risk analysis Risk factors SARS-CoV-2 Severe acute respiratory syndrome Severe acute respiratory syndrome coronavirus 2 Stem cell transplantation Stem Cells Teams Transplantation Viral diseases |
| title | Hematopoietic stem cell transplantation for autoimmune diseases in the time of COVID-19: EBMT guidelines and recommendations |
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