Distinct roles for PARP-1 and PARP-2 in c-Myc–driven B-cell lymphoma in mice

Dysregulation of the c-Myc oncogene occurs in a wide variety of hematologic malignancies, and its overexpression has been linked with aggressive tumor progression. Here, we show that poly (ADP-ribose) polymerase 1 (PARP-1) and PARP-2 exert opposing influences on progression of c-Myc–driven B-cell ly...

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Veröffentlicht in:	Blood 2022-01, Vol.139 (2), p.228-239
Hauptverfasser:	Galindo-Campos, Miguel A., Lutfi, Nura, Bonnin, Sarah, Martínez, Carlos, Velasco-Hernandez, Talia, García-Hernández, Violeta, Martín-Caballero, Juan, Ampurdanés, Coral, Gimeno, Ramón, Colomo, Lluis, Roué, Gaël, Guilbaud, Guillaume, Dantzer, Françoise, Navarro, Pilar, Murga, Matilde, Fernández-Capetillo, Oscar, Bigas, Anna, Menéndez, Pablo, Sale, Julian E., Yélamos, José
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Carcinogenesis - genetics Cellular Biology DNA Damage Gene Deletion Gene Expression Regulation, Neoplastic Hematology Human health and pathology Life Sciences Lymphoma, B-Cell - genetics Mice Mice, Knockout Poly (ADP-Ribose) Polymerase-1 - genetics Poly(ADP-ribose) Polymerases - genetics Proto-Oncogene Proteins c-myc - genetics Subcellular Processes
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