Endocrine disruptors and the male reproductive system
In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism in newborns, and testicular cancer and lower sperm quality in young adult males. In addition, the timing of puberty has also changed over time. Althou...
Gespeichert in:
| Veröffentlicht in: | Baillière's best practice & research. Clinical endocrinology & metabolism 2021-09, Vol.35 (5), p.101567, Article 101567 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 5 |
| container_start_page | 101567 |
| container_title | Baillière's best practice & research. Clinical endocrinology & metabolism |
| container_volume | 35 |
| creator | Stukenborg, Jan-Bernd Mitchell, Rod T. Söder, Olle |
| description | In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism in newborns, and testicular cancer and lower sperm quality in young adult males. In addition, the timing of puberty has also changed over time. Although the cause of these reproductive effects is a matter of intense debate, a link with the presence of ubiquitous compounds in the environment, or the exposure to specific groups of medications during foetal life, has been suggested. Results from epidemiological and experimental studies, as well as clinical observations in humans indicate that endocrine-disrupting chemicals may be associated with those disorders. In this review, we will summarize the results of epidemiological studies and experimental studies utilising human testicular cells or tissue. Due to increasing public interest and the recently published data, the main focus will be on the effects of prenatal exposure to mild analgesics. |
| doi_str_mv | 10.1016/j.beem.2021.101567 |
| format | Article |
| fullrecord | <record><control><sourceid>pubmed_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_459594</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1521690X21000841</els_id><sourcerecordid>34426080</sourcerecordid><originalsourceid>FETCH-LOGICAL-c438t-4e2c799bde284286b28800957a5bddf24f577b995155b91b388c5c792a4a31f53</originalsourceid><addsrcrecordid>eNp9kF1LwzAUhoMobk7_gBfSP9CZpEmbgDcy5gcMvFHwLuTjFDPXdiTdZP_elM5denUOh_d54TwI3RI8J5iU9-u5AWjmFFMyHHhZnaEpEZXICZfsPO2ckryU-HOCrmJcY1wUkpJLNCkYoyUWeIr4snWdDb6FzPkYdtu-CzHTrcv6L8gavYEswDZ0bmd7v4csHmIPzTW6qPUmws1xztDH0_J98ZKv3p5fF4-r3LJC9DkDaispjQMqGBWloUJgLHmluXGupqzmVWWk5IRzI4kphLA8EVQzXZCaFzOUj73xB7Y7o7bBNzocVKe9Op6-0waKcZleTnk65m3oYgxQnwiC1eBMrdXgTA3O1OgsQXcjlOoacCfkT1IKPIwBSK_uPQQVrYfWgvMBbK9c5__r_wUTQ3z9</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>Endocrine disruptors and the male reproductive system</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><source>SWEPUB Freely available online</source><creator>Stukenborg, Jan-Bernd ; Mitchell, Rod T. ; Söder, Olle</creator><creatorcontrib>Stukenborg, Jan-Bernd ; Mitchell, Rod T. ; Söder, Olle</creatorcontrib><description>In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism in newborns, and testicular cancer and lower sperm quality in young adult males. In addition, the timing of puberty has also changed over time. Although the cause of these reproductive effects is a matter of intense debate, a link with the presence of ubiquitous compounds in the environment, or the exposure to specific groups of medications during foetal life, has been suggested. Results from epidemiological and experimental studies, as well as clinical observations in humans indicate that endocrine-disrupting chemicals may be associated with those disorders. In this review, we will summarize the results of epidemiological studies and experimental studies utilising human testicular cells or tissue. Due to increasing public interest and the recently published data, the main focus will be on the effects of prenatal exposure to mild analgesics.</description><identifier>ISSN: 1521-690X</identifier><identifier>EISSN: 1878-1594</identifier><identifier>DOI: 10.1016/j.beem.2021.101567</identifier><identifier>PMID: 34426080</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>analgesics ; Cryptorchidism - chemically induced ; Cryptorchidism - epidemiology ; Endocrine Disruptors - adverse effects ; Endocrine Disruptors - toxicity ; Female ; foetal development ; Genitalia, Male ; germ cells ; Humans ; Infant, Newborn ; infertility ; Male ; Neoplasms, Germ Cell and Embryonal ; Pregnancy ; puberty ; sperm ; Testicular Neoplasms - chemically induced ; Testicular Neoplasms - epidemiology</subject><ispartof>Baillière's best practice & research. Clinical endocrinology & metabolism, 2021-09, Vol.35 (5), p.101567, Article 101567</ispartof><rights>2021 The Author(s)</rights><rights>Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c438t-4e2c799bde284286b28800957a5bddf24f577b995155b91b388c5c792a4a31f53</citedby><cites>FETCH-LOGICAL-c438t-4e2c799bde284286b28800957a5bddf24f577b995155b91b388c5c792a4a31f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1521690X21000841$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34426080$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:147821523$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Stukenborg, Jan-Bernd</creatorcontrib><creatorcontrib>Mitchell, Rod T.</creatorcontrib><creatorcontrib>Söder, Olle</creatorcontrib><title>Endocrine disruptors and the male reproductive system</title><title>Baillière's best practice & research. Clinical endocrinology & metabolism</title><addtitle>Best Pract Res Clin Endocrinol Metab</addtitle><description>In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism in newborns, and testicular cancer and lower sperm quality in young adult males. In addition, the timing of puberty has also changed over time. Although the cause of these reproductive effects is a matter of intense debate, a link with the presence of ubiquitous compounds in the environment, or the exposure to specific groups of medications during foetal life, has been suggested. Results from epidemiological and experimental studies, as well as clinical observations in humans indicate that endocrine-disrupting chemicals may be associated with those disorders. In this review, we will summarize the results of epidemiological studies and experimental studies utilising human testicular cells or tissue. Due to increasing public interest and the recently published data, the main focus will be on the effects of prenatal exposure to mild analgesics.</description><subject>analgesics</subject><subject>Cryptorchidism - chemically induced</subject><subject>Cryptorchidism - epidemiology</subject><subject>Endocrine Disruptors - adverse effects</subject><subject>Endocrine Disruptors - toxicity</subject><subject>Female</subject><subject>foetal development</subject><subject>Genitalia, Male</subject><subject>germ cells</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>infertility</subject><subject>Male</subject><subject>Neoplasms, Germ Cell and Embryonal</subject><subject>Pregnancy</subject><subject>puberty</subject><subject>sperm</subject><subject>Testicular Neoplasms - chemically induced</subject><subject>Testicular Neoplasms - epidemiology</subject><issn>1521-690X</issn><issn>1878-1594</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kF1LwzAUhoMobk7_gBfSP9CZpEmbgDcy5gcMvFHwLuTjFDPXdiTdZP_elM5denUOh_d54TwI3RI8J5iU9-u5AWjmFFMyHHhZnaEpEZXICZfsPO2ckryU-HOCrmJcY1wUkpJLNCkYoyUWeIr4snWdDb6FzPkYdtu-CzHTrcv6L8gavYEswDZ0bmd7v4csHmIPzTW6qPUmws1xztDH0_J98ZKv3p5fF4-r3LJC9DkDaispjQMqGBWloUJgLHmluXGupqzmVWWk5IRzI4kphLA8EVQzXZCaFzOUj73xB7Y7o7bBNzocVKe9Op6-0waKcZleTnk65m3oYgxQnwiC1eBMrdXgTA3O1OgsQXcjlOoacCfkT1IKPIwBSK_uPQQVrYfWgvMBbK9c5__r_wUTQ3z9</recordid><startdate>20210901</startdate><enddate>20210901</enddate><creator>Stukenborg, Jan-Bernd</creator><creator>Mitchell, Rod T.</creator><creator>Söder, Olle</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope></search><sort><creationdate>20210901</creationdate><title>Endocrine disruptors and the male reproductive system</title><author>Stukenborg, Jan-Bernd ; Mitchell, Rod T. ; Söder, Olle</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c438t-4e2c799bde284286b28800957a5bddf24f577b995155b91b388c5c792a4a31f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>analgesics</topic><topic>Cryptorchidism - chemically induced</topic><topic>Cryptorchidism - epidemiology</topic><topic>Endocrine Disruptors - adverse effects</topic><topic>Endocrine Disruptors - toxicity</topic><topic>Female</topic><topic>foetal development</topic><topic>Genitalia, Male</topic><topic>germ cells</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>infertility</topic><topic>Male</topic><topic>Neoplasms, Germ Cell and Embryonal</topic><topic>Pregnancy</topic><topic>puberty</topic><topic>sperm</topic><topic>Testicular Neoplasms - chemically induced</topic><topic>Testicular Neoplasms - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Stukenborg, Jan-Bernd</creatorcontrib><creatorcontrib>Mitchell, Rod T.</creatorcontrib><creatorcontrib>Söder, Olle</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Baillière's best practice & research. Clinical endocrinology & metabolism</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Stukenborg, Jan-Bernd</au><au>Mitchell, Rod T.</au><au>Söder, Olle</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Endocrine disruptors and the male reproductive system</atitle><jtitle>Baillière's best practice & research. Clinical endocrinology & metabolism</jtitle><addtitle>Best Pract Res Clin Endocrinol Metab</addtitle><date>2021-09-01</date><risdate>2021</risdate><volume>35</volume><issue>5</issue><spage>101567</spage><pages>101567-</pages><artnum>101567</artnum><issn>1521-690X</issn><eissn>1878-1594</eissn><abstract>In recent years, there has been an increased incidence in several of the most common reproductive disorders, including hypospadias and cryptorchidism in newborns, and testicular cancer and lower sperm quality in young adult males. In addition, the timing of puberty has also changed over time. Although the cause of these reproductive effects is a matter of intense debate, a link with the presence of ubiquitous compounds in the environment, or the exposure to specific groups of medications during foetal life, has been suggested. Results from epidemiological and experimental studies, as well as clinical observations in humans indicate that endocrine-disrupting chemicals may be associated with those disorders. In this review, we will summarize the results of epidemiological studies and experimental studies utilising human testicular cells or tissue. Due to increasing public interest and the recently published data, the main focus will be on the effects of prenatal exposure to mild analgesics.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>34426080</pmid><doi>10.1016/j.beem.2021.101567</doi><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1521-690X |
| ispartof | Baillière's best practice & research. Clinical endocrinology & metabolism, 2021-09, Vol.35 (5), p.101567, Article 101567 |
| issn | 1521-690X 1878-1594 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_459594 |
| source | MEDLINE; Elsevier ScienceDirect Journals; SWEPUB Freely available online |
| subjects | analgesics Cryptorchidism - chemically induced Cryptorchidism - epidemiology Endocrine Disruptors - adverse effects Endocrine Disruptors - toxicity Female foetal development Genitalia, Male germ cells Humans Infant, Newborn infertility Male Neoplasms, Germ Cell and Embryonal Pregnancy puberty sperm Testicular Neoplasms - chemically induced Testicular Neoplasms - epidemiology |
| title | Endocrine disruptors and the male reproductive system |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T19%3A04%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Endocrine%20disruptors%20and%20the%20male%20reproductive%20system&rft.jtitle=Bailli%C3%A8re's%20best%20practice%20&%20research.%20Clinical%20endocrinology%20&%20metabolism&rft.au=Stukenborg,%20Jan-Bernd&rft.date=2021-09-01&rft.volume=35&rft.issue=5&rft.spage=101567&rft.pages=101567-&rft.artnum=101567&rft.issn=1521-690X&rft.eissn=1878-1594&rft_id=info:doi/10.1016/j.beem.2021.101567&rft_dat=%3Cpubmed_swepu%3E34426080%3C/pubmed_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/34426080&rft_els_id=S1521690X21000841&rfr_iscdi=true |