Not4 and Not5 modulate translation elongation by Rps7A ubiquitination, Rli1 moonlighting, and condensates that exclude eIF5A

In this work, we show that Not4 and Not5 from the Ccr4-Not complex modulate translation elongation dynamics and change ribosome A-site dwelling occupancy in a codon-dependent fashion. These codon-specific changes in not5Δ cells are very robust and independent of codon position within the mRNA, the o...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-08, Vol.36 (9), p.109633-109633, Article 109633
Hauptverfasser:	Allen, George E., Panasenko, Olesya O., Villanyi, Zoltan, Zagatti, Marina, Weiss, Benjamin, Pagliazzo, Lucile, Huch, Susanne, Polte, Christine, Zahoran, Szabolcs, Hughes, Christopher S., Pelechano, Vicent, Ignatova, Zoya, Collart, Martine A.
Format:	Artikel
Sprache:	eng
Schlagworte:	ATP-Binding Cassette Transporters - genetics ATP-Binding Cassette Transporters - metabolism codon optimality Condensates eIF5A Eukaryotic Initiation Factor-5 - genetics Eukaryotic Initiation Factor-5 - metabolism Eukaryotic Translation Initiation Factor 5A Gene Expression Regulation, Fungal Not1 Not4 Not5 Peptide Chain Elongation, Translational Peptide Initiation Factors - genetics Peptide Initiation Factors - metabolism Repressor Proteins - genetics Repressor Proteins - metabolism Ribosome Subunits, Small - genetics Ribosome Subunits, Small - metabolism Ribosomes - genetics Ribosomes - metabolism Rli1 RNA, Fungal - genetics RNA, Fungal - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Signal Transduction Transcription Factors - genetics Transcription Factors - metabolism translation elongation Ubiquitin-Protein Ligases - genetics Ubiquitin-Protein Ligases - metabolism Ubiquitination
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