Trajectories of alcohol consumption during life and the risk of developing breast cancer
Background Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. Objective To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC)....
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| Veröffentlicht in: | British journal of cancer 2021-10, Vol.125 (8), p.1168-1176 |
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| creator | Donat-Vargas, Carolina Guerrero-Zotano, Ángel Casas, Ana Baena-Cañada, José Manuel Lope, Virginia Antolín, Silvia Garcia-Saénz, José Ángel Bermejo, Begoña Muñoz, Montserrat Ramos, Manuel de Juan, Ana Jara Sánchez, Carlos Sánchez-Rovira, Pedro Antón, Antonio Brunet, Joan Gavilá, Joaquín Salvador, Javier Arriola Arellano, Esperanza Bezares, Susana Fernández de Larrea-Baz, Nerea Pérez-Gómez, Beatriz Martín, Miguel Pollán, Marina |
| description | Background
Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive.
Objective
To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC).
Methods
1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women’s lifetime.
Results
Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption ( |
| doi_str_mv | 10.1038/s41416-021-01492-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_459279</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2580805803</sourcerecordid><originalsourceid>FETCH-LOGICAL-c628t-aa6997aa16dd7c0bac556ab72e9da0e24a1b03b49d18de314cb15fed658b54073</originalsourceid><addsrcrecordid>eNp9kUtv1DAUha0K1A4Df4AFisTa4Gdsb5BQVR5SJTat1J3l2DedTDNxsJOO-Pc4zLSlC9j4db9zru2D0FtKPlDC9ccsqKA1JoxiQoVheH-CVlRyhqlm6gVaEUIUJoaRM_Qq523ZGqLVKTrjQmjOuV6hm6vktuCnmDrIVWwr1_u4iX3l45Dn3Th1cajCnLrhtuq7Fio3hGraQJW6fLfwAe6hj-NSbxK4PFXeDR7Sa_SydX2GN8d5ja6_XFydf8OXP75-P_98iX3N9ISdq41RztE6BOVJ47yUtWsUAxMcASYcbQhvhAlUB-BU-IbKFkItdSMFUXyN8ME372GcGzumbufSLxtdZ49Hd2UFVkjDlCm8-Sc_phieRA9CKlRtKGW6aD8dtAXYQfAwTMn1zy2eVYZuY2_jvdWSyOXL1-j90SDFnzPkyW7jnIbyP5ZJTTQpAy8UO1A-xZwTtI8dKLFL8vaQvC3J2z_J230Rvfv7bo-Sh6gLwI8PH5c0IT31_o_tbz6WvdE</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2580805803</pqid></control><display><type>article</type><title>Trajectories of alcohol consumption during life and the risk of developing breast cancer</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>SWEPUB Freely available online</source><source>PubMed Central</source><creator>Donat-Vargas, Carolina ; Guerrero-Zotano, Ángel ; Casas, Ana ; Baena-Cañada, José Manuel ; Lope, Virginia ; Antolín, Silvia ; Garcia-Saénz, José Ángel ; Bermejo, Begoña ; Muñoz, Montserrat ; Ramos, Manuel ; de Juan, Ana ; Jara Sánchez, Carlos ; Sánchez-Rovira, Pedro ; Antón, Antonio ; Brunet, Joan ; Gavilá, Joaquín ; Salvador, Javier ; Arriola Arellano, Esperanza ; Bezares, Susana ; Fernández de Larrea-Baz, Nerea ; Pérez-Gómez, Beatriz ; Martín, Miguel ; Pollán, Marina</creator><creatorcontrib>Donat-Vargas, Carolina ; Guerrero-Zotano, Ángel ; Casas, Ana ; Baena-Cañada, José Manuel ; Lope, Virginia ; Antolín, Silvia ; Garcia-Saénz, José Ángel ; Bermejo, Begoña ; Muñoz, Montserrat ; Ramos, Manuel ; de Juan, Ana ; Jara Sánchez, Carlos ; Sánchez-Rovira, Pedro ; Antón, Antonio ; Brunet, Joan ; Gavilá, Joaquín ; Salvador, Javier ; Arriola Arellano, Esperanza ; Bezares, Susana ; Fernández de Larrea-Baz, Nerea ; Pérez-Gómez, Beatriz ; Martín, Miguel ; Pollán, Marina</creatorcontrib><description>Background
Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive.
Objective
To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC).
Methods
1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women’s lifetime.
Results
Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood.
Conclusions
The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.</description><identifier>ISSN: 0007-0920</identifier><identifier>ISSN: 1532-1827</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/s41416-021-01492-w</identifier><identifier>PMID: 34483338</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/174 ; 692/499 ; Adolescent ; Adolescents ; Adult ; Alcohol ; Alcohol Drinking - adverse effects ; Alcohol Drinking - epidemiology ; Alcohol use ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - epidemiology ; Breast Neoplasms - etiology ; Cancer Research ; Case-Control Studies ; Child development ; Drug Resistance ; Epidemiology ; Female ; Humans ; Invasiveness ; Medicin och hälsovetenskap ; Middle Aged ; Molecular Medicine ; Oncology ; Post-menopause ; Postmenopause ; Premenopause ; Risk Factors ; Spain - epidemiology ; Surveys and Questionnaires ; Underweight ; Young Adult</subject><ispartof>British journal of cancer, 2021-10, Vol.125 (8), p.1168-1176</ispartof><rights>The Author(s) 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c628t-aa6997aa16dd7c0bac556ab72e9da0e24a1b03b49d18de314cb15fed658b54073</citedby><cites>FETCH-LOGICAL-c628t-aa6997aa16dd7c0bac556ab72e9da0e24a1b03b49d18de314cb15fed658b54073</cites><orcidid>0000-0002-4328-1565 ; 0000-0001-9237-3231 ; 0000-0002-4299-8214 ; 0000-0002-6986-4021 ; 0000-0002-4523-4148</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505448/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8505448/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,315,553,728,781,785,886,27926,27927,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34483338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:147691128$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Donat-Vargas, Carolina</creatorcontrib><creatorcontrib>Guerrero-Zotano, Ángel</creatorcontrib><creatorcontrib>Casas, Ana</creatorcontrib><creatorcontrib>Baena-Cañada, José Manuel</creatorcontrib><creatorcontrib>Lope, Virginia</creatorcontrib><creatorcontrib>Antolín, Silvia</creatorcontrib><creatorcontrib>Garcia-Saénz, José Ángel</creatorcontrib><creatorcontrib>Bermejo, Begoña</creatorcontrib><creatorcontrib>Muñoz, Montserrat</creatorcontrib><creatorcontrib>Ramos, Manuel</creatorcontrib><creatorcontrib>de Juan, Ana</creatorcontrib><creatorcontrib>Jara Sánchez, Carlos</creatorcontrib><creatorcontrib>Sánchez-Rovira, Pedro</creatorcontrib><creatorcontrib>Antón, Antonio</creatorcontrib><creatorcontrib>Brunet, Joan</creatorcontrib><creatorcontrib>Gavilá, Joaquín</creatorcontrib><creatorcontrib>Salvador, Javier</creatorcontrib><creatorcontrib>Arriola Arellano, Esperanza</creatorcontrib><creatorcontrib>Bezares, Susana</creatorcontrib><creatorcontrib>Fernández de Larrea-Baz, Nerea</creatorcontrib><creatorcontrib>Pérez-Gómez, Beatriz</creatorcontrib><creatorcontrib>Martín, Miguel</creatorcontrib><creatorcontrib>Pollán, Marina</creatorcontrib><title>Trajectories of alcohol consumption during life and the risk of developing breast cancer</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><addtitle>Br J Cancer</addtitle><description>Background
Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive.
Objective
To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC).
Methods
1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women’s lifetime.
Results
Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood.
Conclusions
The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.</description><subject>692/308/174</subject><subject>692/499</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Adult</subject><subject>Alcohol</subject><subject>Alcohol Drinking - adverse effects</subject><subject>Alcohol Drinking - epidemiology</subject><subject>Alcohol use</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - epidemiology</subject><subject>Breast Neoplasms - etiology</subject><subject>Cancer Research</subject><subject>Case-Control Studies</subject><subject>Child development</subject><subject>Drug Resistance</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Humans</subject><subject>Invasiveness</subject><subject>Medicin och hälsovetenskap</subject><subject>Middle Aged</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Post-menopause</subject><subject>Postmenopause</subject><subject>Premenopause</subject><subject>Risk Factors</subject><subject>Spain - epidemiology</subject><subject>Surveys and Questionnaires</subject><subject>Underweight</subject><subject>Young 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of alcohol consumption during life and the risk of developing breast cancer</title><author>Donat-Vargas, Carolina ; Guerrero-Zotano, Ángel ; Casas, Ana ; Baena-Cañada, José Manuel ; Lope, Virginia ; Antolín, Silvia ; Garcia-Saénz, José Ángel ; Bermejo, Begoña ; Muñoz, Montserrat ; Ramos, Manuel ; de Juan, Ana ; Jara Sánchez, Carlos ; Sánchez-Rovira, Pedro ; Antón, Antonio ; Brunet, Joan ; Gavilá, Joaquín ; Salvador, Javier ; Arriola Arellano, Esperanza ; Bezares, Susana ; Fernández de Larrea-Baz, Nerea ; Pérez-Gómez, Beatriz ; Martín, Miguel ; Pollán, Marina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c628t-aa6997aa16dd7c0bac556ab72e9da0e24a1b03b49d18de314cb15fed658b54073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>692/308/174</topic><topic>692/499</topic><topic>Adolescent</topic><topic>Adolescents</topic><topic>Adult</topic><topic>Alcohol</topic><topic>Alcohol Drinking - adverse effects</topic><topic>Alcohol Drinking - epidemiology</topic><topic>Alcohol use</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - epidemiology</topic><topic>Breast Neoplasms - etiology</topic><topic>Cancer Research</topic><topic>Case-Control Studies</topic><topic>Child development</topic><topic>Drug Resistance</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Humans</topic><topic>Invasiveness</topic><topic>Medicin och hälsovetenskap</topic><topic>Middle Aged</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Post-menopause</topic><topic>Postmenopause</topic><topic>Premenopause</topic><topic>Risk Factors</topic><topic>Spain - epidemiology</topic><topic>Surveys and Questionnaires</topic><topic>Underweight</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Donat-Vargas, 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cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Donat-Vargas, Carolina</au><au>Guerrero-Zotano, Ángel</au><au>Casas, Ana</au><au>Baena-Cañada, José Manuel</au><au>Lope, Virginia</au><au>Antolín, Silvia</au><au>Garcia-Saénz, José Ángel</au><au>Bermejo, Begoña</au><au>Muñoz, Montserrat</au><au>Ramos, Manuel</au><au>de Juan, Ana</au><au>Jara Sánchez, Carlos</au><au>Sánchez-Rovira, Pedro</au><au>Antón, Antonio</au><au>Brunet, Joan</au><au>Gavilá, Joaquín</au><au>Salvador, Javier</au><au>Arriola Arellano, Esperanza</au><au>Bezares, Susana</au><au>Fernández de Larrea-Baz, Nerea</au><au>Pérez-Gómez, Beatriz</au><au>Martín, Miguel</au><au>Pollán, Marina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Trajectories of alcohol consumption during life and the risk of developing breast cancer</atitle><jtitle>British journal of cancer</jtitle><stitle>Br J Cancer</stitle><addtitle>Br J Cancer</addtitle><date>2021-10-12</date><risdate>2021</risdate><volume>125</volume><issue>8</issue><spage>1168</spage><epage>1176</epage><pages>1168-1176</pages><issn>0007-0920</issn><issn>1532-1827</issn><eissn>1532-1827</eissn><abstract>Background
Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive.
Objective
To compare the influence of distinctive trajectories of alcohol consumption throughout a woman’s life on development of breast cancer (BC).
Methods
1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women’s lifetime.
Results
Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood.
Conclusions
The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>34483338</pmid><doi>10.1038/s41416-021-01492-w</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4328-1565</orcidid><orcidid>https://orcid.org/0000-0001-9237-3231</orcidid><orcidid>https://orcid.org/0000-0002-4299-8214</orcidid><orcidid>https://orcid.org/0000-0002-6986-4021</orcidid><orcidid>https://orcid.org/0000-0002-4523-4148</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0920 |
| ispartof | British journal of cancer, 2021-10, Vol.125 (8), p.1168-1176 |
| issn | 0007-0920 1532-1827 1532-1827 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_459279 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; SWEPUB Freely available online; PubMed Central |
| subjects | 692/308/174 692/499 Adolescent Adolescents Adult Alcohol Alcohol Drinking - adverse effects Alcohol Drinking - epidemiology Alcohol use Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - epidemiology Breast Neoplasms - etiology Cancer Research Case-Control Studies Child development Drug Resistance Epidemiology Female Humans Invasiveness Medicin och hälsovetenskap Middle Aged Molecular Medicine Oncology Post-menopause Postmenopause Premenopause Risk Factors Spain - epidemiology Surveys and Questionnaires Underweight Young Adult |
| title | Trajectories of alcohol consumption during life and the risk of developing breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-18T07%3A56%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Trajectories%20of%20alcohol%20consumption%20during%20life%20and%20the%20risk%20of%20developing%20breast%20cancer&rft.jtitle=British%20journal%20of%20cancer&rft.au=Donat-Vargas,%20Carolina&rft.date=2021-10-12&rft.volume=125&rft.issue=8&rft.spage=1168&rft.epage=1176&rft.pages=1168-1176&rft.issn=0007-0920&rft.eissn=1532-1827&rft_id=info:doi/10.1038/s41416-021-01492-w&rft_dat=%3Cproquest_swepu%3E2580805803%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2580805803&rft_id=info:pmid/34483338&rfr_iscdi=true |