USP7 and VCP FAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork

The AAA ATPase VCP regulates the extraction of SUMO and ubiquitin-modified DNA replication factors from chromatin. We have previously described that active DNA synthesis is associated with a SUMO-high/ubiquitin-low environment governed by the deubiquitylase USP7. Here, we unveil a functional coopera...

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Veröffentlicht in:	Cell reports (Cambridge) 2021-10, Vol.37 (2), p.109819
Hauptverfasser:	Franz, André, Valledor, Pablo, Ubieto-Capella, Patricia, Pilger, Domenic, Galarreta, Antonio, Lafarga, Vanesa, Fernández-Llorente, Alejandro, de la Vega-Barranco, Guillermo, den Brave, Fabian, Hoppe, Thorsten, Fernandez-Capetillo, Oscar, Lecona, Emilio
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Animals, Genetically Modified Apoptosis Regulatory Proteins - genetics Apoptosis Regulatory Proteins - metabolism Caenorhabditis elegans - genetics Caenorhabditis elegans - metabolism Caenorhabditis elegans Proteins - genetics Caenorhabditis elegans Proteins - metabolism Carrier Proteins - genetics Carrier Proteins - metabolism Chromatin - genetics Chromatin - metabolism DNA Replication Endopeptidases - genetics Endopeptidases - metabolism Evolution, Molecular HCT116 Cells HeLa Cells Humans MCF-7 Cells Sumoylation Ubiquitin-Specific Peptidase 7 - genetics Ubiquitin-Specific Peptidase 7 - metabolism Ubiquitination Valosin Containing Protein - genetics Valosin Containing Protein - metabolism
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