The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)
Introduction Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre‐specified subgroup analyses). Methods FINGER is a multicenter...
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| Veröffentlicht in: | Alzheimer's & dementia 2022-07, Vol.18 (7), p.1325-1334 |
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| creator | Ngandu, Tiia Lehtisalo, Jenni Korkki, Saana Solomon, Alina Coley, Nicola Antikainen, Riitta Bäckman, Lars Hänninen, Tuomo Lindström, Jaana Laatikainen, Tiina Paajanen, Teemu Havulinna, Satu Peltonen, Markku Neely, Anna Stigsdotter Strandberg, Timo Tuomilehto, Jaakko Soininen, Hilkka Kivipelto, Miia |
| description | Introduction
Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre‐specified subgroup analyses).
Methods
FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self‐reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.
Results
Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.
Discussion
Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential. |
| doi_str_mv | 10.1002/alz.12492 |
| format | Article |
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Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre‐specified subgroup analyses).
Methods
FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self‐reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.
Results
Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.
Discussion
Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.</description><identifier>ISSN: 1552-5260</identifier><identifier>ISSN: 1552-5279</identifier><identifier>EISSN: 1552-5279</identifier><identifier>DOI: 10.1002/alz.12492</identifier><identifier>PMID: 34668644</identifier><language>eng</language><publisher>Alzheimer's Association / Wiley</publisher><subject>cognition ; Engineering Psychology ; Life Sciences ; lifestyle ; Medicin och hälsovetenskap ; multidomain ; prevention ; Psychology with an emphasis on medical psychology ; Psykologi inr. medicinsk psykologi ; Teknisk psykologi</subject><ispartof>Alzheimer's & dementia, 2022-07, Vol.18 (7), p.1325-1334</ispartof><rights>2021 The Authors. published by Wiley Periodicals LLC on behalf of Alzheimer's Association.</rights><rights>Attribution - NonCommercial</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5332-d22ad4fd6f4e85947f6c7da92cc0d045d318b4a19c5f3511286aa800bab21bc03</citedby><cites>FETCH-LOGICAL-c5332-d22ad4fd6f4e85947f6c7da92cc0d045d318b4a19c5f3511286aa800bab21bc03</cites><orcidid>0000-0002-3698-2021 ; 0000-0002-1671-824X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falz.12492$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falz.12492$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>230,314,552,780,784,885,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://ut3-toulouseinp.hal.science/hal-04505058$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-87338$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-87619$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:148003849$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Ngandu, Tiia</creatorcontrib><creatorcontrib>Lehtisalo, Jenni</creatorcontrib><creatorcontrib>Korkki, Saana</creatorcontrib><creatorcontrib>Solomon, Alina</creatorcontrib><creatorcontrib>Coley, Nicola</creatorcontrib><creatorcontrib>Antikainen, Riitta</creatorcontrib><creatorcontrib>Bäckman, Lars</creatorcontrib><creatorcontrib>Hänninen, Tuomo</creatorcontrib><creatorcontrib>Lindström, Jaana</creatorcontrib><creatorcontrib>Laatikainen, Tiina</creatorcontrib><creatorcontrib>Paajanen, Teemu</creatorcontrib><creatorcontrib>Havulinna, Satu</creatorcontrib><creatorcontrib>Peltonen, Markku</creatorcontrib><creatorcontrib>Neely, Anna Stigsdotter</creatorcontrib><creatorcontrib>Strandberg, Timo</creatorcontrib><creatorcontrib>Tuomilehto, Jaakko</creatorcontrib><creatorcontrib>Soininen, Hilkka</creatorcontrib><creatorcontrib>Kivipelto, Miia</creatorcontrib><title>The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)</title><title>Alzheimer's & dementia</title><description>Introduction
Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre‐specified subgroup analyses).
Methods
FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self‐reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.
Results
Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.
Discussion
Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.</description><subject>cognition</subject><subject>Engineering Psychology</subject><subject>Life Sciences</subject><subject>lifestyle</subject><subject>Medicin och hälsovetenskap</subject><subject>multidomain</subject><subject>prevention</subject><subject>Psychology with an emphasis on medical psychology</subject><subject>Psykologi inr. medicinsk psykologi</subject><subject>Teknisk psykologi</subject><issn>1552-5260</issn><issn>1552-5279</issn><issn>1552-5279</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>D8T</sourceid><recordid>eNqNkk1P3DAQhq2qVaGUQ_9BjiAR8Pc6xxXf0opKFfTAxXLsMeviTbZxAlp-fb0EtuphpcoHz4yf97U1HoS-EXxMMKYnJr4cE8or-gHtEiFoKeik-riJJd5BX1L6hTHHiojPaIdxKZXkfBfd3c6hAO_B9kXrC-Pm0EFjoWibwrYPTehDjkJTmGIxxD64dmFyFoOH1K8i5KMeuidoXrmDi-uby_Mfh1_RJ29igv23fQ_dXZzfnl6Vs--X16fTWWkFY7R0lBrHvZOegxIVn3hpJ85U1FrsMBeOEVVzQyorPBOEUCWNURjXpqaktpjtoXL0Tc-wHGq97MLCdCvdmqDfSo85As2FIkpmvtrKL7vW_RW9CwnP9zHFq6w92qo9Cz-nuu0edOwHrSaS_Cf-aNY4YyrjhyM-N_Ef9mo60-tabgfOSz2RzB6MbH7y7yH_g16EZCFG00A7JE2F4phInnu8sbVdm1IHfuNNsF7Pjs6zo19nJ7MnI_scIqy2g3o6ux8VfwCgNsRA</recordid><startdate>202207</startdate><enddate>202207</enddate><creator>Ngandu, Tiia</creator><creator>Lehtisalo, Jenni</creator><creator>Korkki, Saana</creator><creator>Solomon, Alina</creator><creator>Coley, Nicola</creator><creator>Antikainen, Riitta</creator><creator>Bäckman, Lars</creator><creator>Hänninen, Tuomo</creator><creator>Lindström, Jaana</creator><creator>Laatikainen, Tiina</creator><creator>Paajanen, Teemu</creator><creator>Havulinna, Satu</creator><creator>Peltonen, Markku</creator><creator>Neely, Anna Stigsdotter</creator><creator>Strandberg, Timo</creator><creator>Tuomilehto, Jaakko</creator><creator>Soininen, Hilkka</creator><creator>Kivipelto, Miia</creator><general>Alzheimer's Association / Wiley</general><scope>24P</scope><scope>WIN</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>1XC</scope><scope>VOOES</scope><scope>AAMOE</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>DG3</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-3698-2021</orcidid><orcidid>https://orcid.org/0000-0002-1671-824X</orcidid></search><sort><creationdate>202207</creationdate><title>The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)</title><author>Ngandu, Tiia ; Lehtisalo, Jenni ; Korkki, Saana ; Solomon, Alina ; Coley, Nicola ; Antikainen, Riitta ; Bäckman, Lars ; Hänninen, Tuomo ; Lindström, Jaana ; Laatikainen, Tiina ; Paajanen, Teemu ; Havulinna, Satu ; Peltonen, Markku ; Neely, Anna Stigsdotter ; Strandberg, Timo ; Tuomilehto, Jaakko ; Soininen, Hilkka ; Kivipelto, Miia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5332-d22ad4fd6f4e85947f6c7da92cc0d045d318b4a19c5f3511286aa800bab21bc03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>cognition</topic><topic>Engineering Psychology</topic><topic>Life Sciences</topic><topic>lifestyle</topic><topic>Medicin och hälsovetenskap</topic><topic>multidomain</topic><topic>prevention</topic><topic>Psychology with an emphasis on medical psychology</topic><topic>Psykologi inr. medicinsk psykologi</topic><topic>Teknisk psykologi</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ngandu, Tiia</creatorcontrib><creatorcontrib>Lehtisalo, Jenni</creatorcontrib><creatorcontrib>Korkki, Saana</creatorcontrib><creatorcontrib>Solomon, Alina</creatorcontrib><creatorcontrib>Coley, Nicola</creatorcontrib><creatorcontrib>Antikainen, Riitta</creatorcontrib><creatorcontrib>Bäckman, Lars</creatorcontrib><creatorcontrib>Hänninen, Tuomo</creatorcontrib><creatorcontrib>Lindström, Jaana</creatorcontrib><creatorcontrib>Laatikainen, Tiina</creatorcontrib><creatorcontrib>Paajanen, Teemu</creatorcontrib><creatorcontrib>Havulinna, Satu</creatorcontrib><creatorcontrib>Peltonen, Markku</creatorcontrib><creatorcontrib>Neely, Anna Stigsdotter</creatorcontrib><creatorcontrib>Strandberg, Timo</creatorcontrib><creatorcontrib>Tuomilehto, Jaakko</creatorcontrib><creatorcontrib>Soininen, Hilkka</creatorcontrib><creatorcontrib>Kivipelto, Miia</creatorcontrib><collection>Wiley-Blackwell Open Access Titles</collection><collection>Wiley Free Content</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>SWEPUB Karlstads universitet full text</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SWEPUB Karlstads universitet</collection><collection>SwePub Articles full text</collection><jtitle>Alzheimer's & dementia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ngandu, Tiia</au><au>Lehtisalo, Jenni</au><au>Korkki, Saana</au><au>Solomon, Alina</au><au>Coley, Nicola</au><au>Antikainen, Riitta</au><au>Bäckman, Lars</au><au>Hänninen, Tuomo</au><au>Lindström, Jaana</au><au>Laatikainen, Tiina</au><au>Paajanen, Teemu</au><au>Havulinna, Satu</au><au>Peltonen, Markku</au><au>Neely, Anna Stigsdotter</au><au>Strandberg, Timo</au><au>Tuomilehto, Jaakko</au><au>Soininen, Hilkka</au><au>Kivipelto, Miia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER)</atitle><jtitle>Alzheimer's & dementia</jtitle><date>2022-07</date><risdate>2022</risdate><volume>18</volume><issue>7</issue><spage>1325</spage><epage>1334</epage><pages>1325-1334</pages><issn>1552-5260</issn><issn>1552-5279</issn><eissn>1552-5279</eissn><abstract>Introduction
Lifestyle interventions may prevent cognitive decline, but the sufficient dose of intervention activities and lifestyle changes is unknown. We investigated how intervention adherence affects cognition in the FINGER trial (pre‐specified subgroup analyses).
Methods
FINGER is a multicenter randomized controlled trial examining the efficacy of multidomain lifestyle intervention (ClinicalTrials.gov NCT01041989). A total of 1260 participants aged 60 to 77 with increased dementia risk were randomized to a lifestyle intervention and control groups. Percentage of completed intervention sessions, and change in multidomain lifestyle score (self‐reported diet; physical, cognitive, and social activity; vascular risk) were examined in relation to change in Neuropsychological Test Battery (NTB) scores.
Results
Active participation was associated with better trajectories in NTB total and all cognitive subdomains. Improvement in lifestyle was associated with improvement in NTB total and executive function.
Discussion
Multidomain lifestyle changes are beneficial for cognitive functioning, but future interventions should be intensive enough, and supporting adherence is essential.</abstract><pub>Alzheimer's Association / Wiley</pub><pmid>34668644</pmid><doi>10.1002/alz.12492</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-3698-2021</orcidid><orcidid>https://orcid.org/0000-0002-1671-824X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | cognition Engineering Psychology Life Sciences lifestyle Medicin och hälsovetenskap multidomain prevention Psychology with an emphasis on medical psychology Psykologi inr. medicinsk psykologi Teknisk psykologi |
| title | The effect of adherence on cognition in a multidomain lifestyle intervention (FINGER) |
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