Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species
Background. Over the past decade, drug resistance pattern has worsened for many of the uropathogens due to overuse of antibiotics for empiric treatment. The burden of extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae associated urinary tract infections (UTI) has become increasingl...
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| description | Background. Over the past decade, drug resistance pattern has worsened for many of the uropathogens due to overuse of antibiotics for empiric treatment. The burden of extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae associated urinary tract infections (UTI) has become increasingly more common, limiting treatment options among children presenting with febrile UTI. We investigated the burden and correlates of ESBL producing Enterobacteriaceae associated UTI among children and antibacterial resistance pattern. Methods. 284 midstream urine specimens were collected using standard aseptic techniques from 284 children who were diagnosed with suspected UTI. Urine culture and bacteria isolation were performed following standard bacteriological techniques. The Kirby-Bauer disk diffusion technique and the double-disc synergy test were used to investigate antibiotic susceptibility and presence of ESBL production. Results. UTI was confirmed using a positive urine culture for a relevant pathogen in 96/284 (33.8%) of the cases. Enterobacteriaceae accounted for 75% (72/96) of etiologies of UTI in children. The most frequent Enterobacteriaceae spp. were E. coli, 44.4% (32/72) and K. pneumonia, 27.8% (20/72). The overall multidrug resistance rate was 86.1% (62/72). ESBL-producers accounted for 41.7% (30/72) of the isolated Enterobacteriaceae. ESBL producing K. pneumonia and E. coli isolates accounted for 70% (14/20) and 37.5% (12/32), respectively. History of UTI in the past 1 year (adjusted odds ratio AoR=0.08,95%CI 0.01−0.57) and medium family wealth index (AoR=0.03,95%CI 0.00−0.27) protected from infection with ESBL-producing Enterobacteriaceae. Conclusion. ESBL production was more common in K. pneumonia and appeared to be a major factor contributing drug resistance UTI in children. The findings call for the need to incorporate ESBL testing in the routine clinical practice. The resistance level to commonly prescribed first-line antibiotics observed within Enterobacteriaceae was alarming calling for strengthened antimicrobial stewardship. |
| doi_str_mv | 10.1155/2020/6679029 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_458076</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A697105552</galeid><sourcerecordid>A697105552</sourcerecordid><originalsourceid>FETCH-LOGICAL-c537t-a5e13b38a424b8e59bffce4696bd4f5aacddc11f2f89e210081e001453e330c43</originalsourceid><addsrcrecordid>eNqNks9rFDEUxwdRbKm9eZaAF8GOze_NXIS6bLWwYKHtUUIm87JNnU3WZMbS_74Zdt1aT-aSR94n3_de8q2qtwR_IkSIU4opPpVy1mDavKgOKSO8loSTl_uYsYPqOOc7XJYiEjfydXXAuGyoovyw-nEJnTdD8hadQ5t8D-gm-WDSA7pOxg7oIjiwg48Bzc2YoUPtA1pcfVmiyxS70fqwQoswQIptoSF5Y8EAutqA9ZDfVK-c6TMc7_aj6uZ8cT3_Vi-_f72Yny1rK9hsqI0AwlqmDKe8VSCa1jkLpUfZdtwJY2zXWUIcdaoBSqZBAGPCBQPGsOXsqKq3uvkeNmOrN8mvywg6Gq93Rz9LBJoLhWey8J-3fMmsobMQhmT6Z9eeZ4K_1av4WytBpVJTwQ87gRR_jZAHvfbZQt-bAHHMmgolGsrpjBb0_T_oXRxTKM-h6TSiwkyRJ2pletA-uFjq2klUn8lmRrAQYtI62VI2xZwTuH3LBOvJEHoyhN4ZouDv_h5zD__5_gJ83AK3PnTm3v-nHBQGnHmiCSvGatgjLvPGqA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2469680381</pqid></control><display><type>article</type><title>Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species</title><source>MEDLINE</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>SWEPUB Freely available online</source><source>PubMed Central Open Access</source><creator>Lulu, Birhanu ; Nigussie, Demiss ; Worku, Mesfin ; Agegnehu, Asnakech ; Tadesse, Birkneh Tilahun</creator><contributor>Karadeniz, Cem ; Cem Karadeniz</contributor><creatorcontrib>Lulu, Birhanu ; Nigussie, Demiss ; Worku, Mesfin ; Agegnehu, Asnakech ; Tadesse, Birkneh Tilahun ; Karadeniz, Cem ; Cem Karadeniz</creatorcontrib><description>Background. Over the past decade, drug resistance pattern has worsened for many of the uropathogens due to overuse of antibiotics for empiric treatment. The burden of extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae associated urinary tract infections (UTI) has become increasingly more common, limiting treatment options among children presenting with febrile UTI. We investigated the burden and correlates of ESBL producing Enterobacteriaceae associated UTI among children and antibacterial resistance pattern. Methods. 284 midstream urine specimens were collected using standard aseptic techniques from 284 children who were diagnosed with suspected UTI. Urine culture and bacteria isolation were performed following standard bacteriological techniques. The Kirby-Bauer disk diffusion technique and the double-disc synergy test were used to investigate antibiotic susceptibility and presence of ESBL production. Results. UTI was confirmed using a positive urine culture for a relevant pathogen in 96/284 (33.8%) of the cases. Enterobacteriaceae accounted for 75% (72/96) of etiologies of UTI in children. The most frequent Enterobacteriaceae spp. were E. coli, 44.4% (32/72) and K. pneumonia, 27.8% (20/72). The overall multidrug resistance rate was 86.1% (62/72). ESBL-producers accounted for 41.7% (30/72) of the isolated Enterobacteriaceae. ESBL producing K. pneumonia and E. coli isolates accounted for 70% (14/20) and 37.5% (12/32), respectively. History of UTI in the past 1 year (adjusted odds ratio AoR=0.08,95%CI 0.01−0.57) and medium family wealth index (AoR=0.03,95%CI 0.00−0.27) protected from infection with ESBL-producing Enterobacteriaceae. Conclusion. ESBL production was more common in K. pneumonia and appeared to be a major factor contributing drug resistance UTI in children. The findings call for the need to incorporate ESBL testing in the routine clinical practice. The resistance level to commonly prescribed first-line antibiotics observed within Enterobacteriaceae was alarming calling for strengthened antimicrobial stewardship.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2020/6679029</identifier><identifier>PMID: 34692824</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Adolescent ; Age ; Anti-Bacterial Agents - therapeutic use ; Antibiotics ; Antimicrobial agents ; Bacteria ; Bacterial infections ; beta-Lactamases - biosynthesis ; Causes of ; Child ; Child, Preschool ; Children ; Communicable diseases in children ; Complications and side effects ; Culture ; Data collection ; Diagnosis ; Disk Diffusion Antimicrobial Tests - methods ; Drug resistance ; Drug resistance in microorganisms ; Drug Resistance, Bacterial ; Drug therapy ; E coli ; Education ; Enterobacteriaceae ; Enterobacteriaceae - isolation & purification ; Enterobacteriaceae - pathogenicity ; Enterobacteriaceae infections ; Enterobacteriaceae Infections - diagnosis ; Enterobacteriaceae Infections - microbiology ; Enterobacteriaceae Infections - pathology ; Enzymes ; Etiology ; Female ; Gram-negative bacteria ; Humans ; Infant ; Infant, Newborn ; Infections ; Laboratories ; Male ; Microbial Sensitivity Tests - methods ; Multidrug resistance ; Pediatric research ; Pediatrics ; Penicillin ; Pneumonia ; Principal components analysis ; Resistance factors ; Sample size ; Urinary tract ; Urinary tract diseases ; Urinary tract infections ; Urinary Tract Infections - diagnosis ; Urinary Tract Infections - microbiology ; Urinary Tract Infections - pathology ; Urine ; Urogenital system ; β Lactamase</subject><ispartof>BioMed research international, 2020, Vol.2020 (2020), p.1-8</ispartof><rights>Copyright © 2020 Asnakech Agegnehu et al.</rights><rights>COPYRIGHT 2020 John Wiley & Sons, Inc.</rights><rights>Copyright © 2020 Asnakech Agegnehu et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2020 Asnakech Agegnehu et al. 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c537t-a5e13b38a424b8e59bffce4696bd4f5aacddc11f2f89e210081e001453e330c43</citedby><cites>FETCH-LOGICAL-c537t-a5e13b38a424b8e59bffce4696bd4f5aacddc11f2f89e210081e001453e330c43</cites><orcidid>0000-0003-4005-8605</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526884/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8526884/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34692824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:145390024$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><contributor>Karadeniz, Cem</contributor><contributor>Cem Karadeniz</contributor><creatorcontrib>Lulu, Birhanu</creatorcontrib><creatorcontrib>Nigussie, Demiss</creatorcontrib><creatorcontrib>Worku, Mesfin</creatorcontrib><creatorcontrib>Agegnehu, Asnakech</creatorcontrib><creatorcontrib>Tadesse, Birkneh Tilahun</creatorcontrib><title>Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Background. Over the past decade, drug resistance pattern has worsened for many of the uropathogens due to overuse of antibiotics for empiric treatment. The burden of extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae associated urinary tract infections (UTI) has become increasingly more common, limiting treatment options among children presenting with febrile UTI. We investigated the burden and correlates of ESBL producing Enterobacteriaceae associated UTI among children and antibacterial resistance pattern. Methods. 284 midstream urine specimens were collected using standard aseptic techniques from 284 children who were diagnosed with suspected UTI. Urine culture and bacteria isolation were performed following standard bacteriological techniques. The Kirby-Bauer disk diffusion technique and the double-disc synergy test were used to investigate antibiotic susceptibility and presence of ESBL production. Results. UTI was confirmed using a positive urine culture for a relevant pathogen in 96/284 (33.8%) of the cases. Enterobacteriaceae accounted for 75% (72/96) of etiologies of UTI in children. The most frequent Enterobacteriaceae spp. were E. coli, 44.4% (32/72) and K. pneumonia, 27.8% (20/72). The overall multidrug resistance rate was 86.1% (62/72). ESBL-producers accounted for 41.7% (30/72) of the isolated Enterobacteriaceae. ESBL producing K. pneumonia and E. coli isolates accounted for 70% (14/20) and 37.5% (12/32), respectively. History of UTI in the past 1 year (adjusted odds ratio AoR=0.08,95%CI 0.01−0.57) and medium family wealth index (AoR=0.03,95%CI 0.00−0.27) protected from infection with ESBL-producing Enterobacteriaceae. Conclusion. ESBL production was more common in K. pneumonia and appeared to be a major factor contributing drug resistance UTI in children. The findings call for the need to incorporate ESBL testing in the routine clinical practice. The resistance level to commonly prescribed first-line antibiotics observed within Enterobacteriaceae was alarming calling for strengthened antimicrobial stewardship.</description><subject>Adolescent</subject><subject>Age</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Antibiotics</subject><subject>Antimicrobial agents</subject><subject>Bacteria</subject><subject>Bacterial infections</subject><subject>beta-Lactamases - biosynthesis</subject><subject>Causes of</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Communicable diseases in children</subject><subject>Complications and side effects</subject><subject>Culture</subject><subject>Data collection</subject><subject>Diagnosis</subject><subject>Disk Diffusion Antimicrobial Tests - methods</subject><subject>Drug resistance</subject><subject>Drug resistance in microorganisms</subject><subject>Drug Resistance, Bacterial</subject><subject>Drug therapy</subject><subject>E coli</subject><subject>Education</subject><subject>Enterobacteriaceae</subject><subject>Enterobacteriaceae - isolation & purification</subject><subject>Enterobacteriaceae - pathogenicity</subject><subject>Enterobacteriaceae infections</subject><subject>Enterobacteriaceae Infections - diagnosis</subject><subject>Enterobacteriaceae Infections - microbiology</subject><subject>Enterobacteriaceae Infections - pathology</subject><subject>Enzymes</subject><subject>Etiology</subject><subject>Female</subject><subject>Gram-negative bacteria</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Male</subject><subject>Microbial Sensitivity Tests - methods</subject><subject>Multidrug resistance</subject><subject>Pediatric research</subject><subject>Pediatrics</subject><subject>Penicillin</subject><subject>Pneumonia</subject><subject>Principal components analysis</subject><subject>Resistance factors</subject><subject>Sample size</subject><subject>Urinary tract</subject><subject>Urinary tract diseases</subject><subject>Urinary tract infections</subject><subject>Urinary Tract Infections - diagnosis</subject><subject>Urinary Tract Infections - microbiology</subject><subject>Urinary Tract Infections - pathology</subject><subject>Urine</subject><subject>Urogenital system</subject><subject>β Lactamase</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><sourceid>D8T</sourceid><recordid>eNqNks9rFDEUxwdRbKm9eZaAF8GOze_NXIS6bLWwYKHtUUIm87JNnU3WZMbS_74Zdt1aT-aSR94n3_de8q2qtwR_IkSIU4opPpVy1mDavKgOKSO8loSTl_uYsYPqOOc7XJYiEjfydXXAuGyoovyw-nEJnTdD8hadQ5t8D-gm-WDSA7pOxg7oIjiwg48Bzc2YoUPtA1pcfVmiyxS70fqwQoswQIptoSF5Y8EAutqA9ZDfVK-c6TMc7_aj6uZ8cT3_Vi-_f72Yny1rK9hsqI0AwlqmDKe8VSCa1jkLpUfZdtwJY2zXWUIcdaoBSqZBAGPCBQPGsOXsqKq3uvkeNmOrN8mvywg6Gq93Rz9LBJoLhWey8J-3fMmsobMQhmT6Z9eeZ4K_1av4WytBpVJTwQ87gRR_jZAHvfbZQt-bAHHMmgolGsrpjBb0_T_oXRxTKM-h6TSiwkyRJ2pletA-uFjq2klUn8lmRrAQYtI62VI2xZwTuH3LBOvJEHoyhN4ZouDv_h5zD__5_gJ83AK3PnTm3v-nHBQGnHmiCSvGatgjLvPGqA</recordid><startdate>2020</startdate><enddate>2020</enddate><creator>Lulu, Birhanu</creator><creator>Nigussie, Demiss</creator><creator>Worku, Mesfin</creator><creator>Agegnehu, Asnakech</creator><creator>Tadesse, Birkneh Tilahun</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-4005-8605</orcidid></search><sort><creationdate>2020</creationdate><title>Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species</title><author>Lulu, Birhanu ; Nigussie, Demiss ; Worku, Mesfin ; Agegnehu, Asnakech ; Tadesse, Birkneh Tilahun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c537t-a5e13b38a424b8e59bffce4696bd4f5aacddc11f2f89e210081e001453e330c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adolescent</topic><topic>Age</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Antibiotics</topic><topic>Antimicrobial agents</topic><topic>Bacteria</topic><topic>Bacterial infections</topic><topic>beta-Lactamases - biosynthesis</topic><topic>Causes of</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Communicable diseases in children</topic><topic>Complications and side effects</topic><topic>Culture</topic><topic>Data collection</topic><topic>Diagnosis</topic><topic>Disk Diffusion Antimicrobial Tests - methods</topic><topic>Drug resistance</topic><topic>Drug resistance in microorganisms</topic><topic>Drug Resistance, Bacterial</topic><topic>Drug therapy</topic><topic>E coli</topic><topic>Education</topic><topic>Enterobacteriaceae</topic><topic>Enterobacteriaceae - isolation & purification</topic><topic>Enterobacteriaceae - pathogenicity</topic><topic>Enterobacteriaceae infections</topic><topic>Enterobacteriaceae Infections - diagnosis</topic><topic>Enterobacteriaceae Infections - microbiology</topic><topic>Enterobacteriaceae Infections - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lulu, Birhanu</au><au>Nigussie, Demiss</au><au>Worku, Mesfin</au><au>Agegnehu, Asnakech</au><au>Tadesse, Birkneh Tilahun</au><au>Karadeniz, Cem</au><au>Cem Karadeniz</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2020</date><risdate>2020</risdate><volume>2020</volume><issue>2020</issue><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Background. Over the past decade, drug resistance pattern has worsened for many of the uropathogens due to overuse of antibiotics for empiric treatment. The burden of extended spectrum beta-lactamase (ESBL) producing Enterobacteriaceae associated urinary tract infections (UTI) has become increasingly more common, limiting treatment options among children presenting with febrile UTI. We investigated the burden and correlates of ESBL producing Enterobacteriaceae associated UTI among children and antibacterial resistance pattern. Methods. 284 midstream urine specimens were collected using standard aseptic techniques from 284 children who were diagnosed with suspected UTI. Urine culture and bacteria isolation were performed following standard bacteriological techniques. The Kirby-Bauer disk diffusion technique and the double-disc synergy test were used to investigate antibiotic susceptibility and presence of ESBL production. Results. UTI was confirmed using a positive urine culture for a relevant pathogen in 96/284 (33.8%) of the cases. Enterobacteriaceae accounted for 75% (72/96) of etiologies of UTI in children. The most frequent Enterobacteriaceae spp. were E. coli, 44.4% (32/72) and K. pneumonia, 27.8% (20/72). The overall multidrug resistance rate was 86.1% (62/72). ESBL-producers accounted for 41.7% (30/72) of the isolated Enterobacteriaceae. ESBL producing K. pneumonia and E. coli isolates accounted for 70% (14/20) and 37.5% (12/32), respectively. History of UTI in the past 1 year (adjusted odds ratio AoR=0.08,95%CI 0.01−0.57) and medium family wealth index (AoR=0.03,95%CI 0.00−0.27) protected from infection with ESBL-producing Enterobacteriaceae. Conclusion. ESBL production was more common in K. pneumonia and appeared to be a major factor contributing drug resistance UTI in children. The findings call for the need to incorporate ESBL testing in the routine clinical practice. The resistance level to commonly prescribed first-line antibiotics observed within Enterobacteriaceae was alarming calling for strengthened antimicrobial stewardship.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>34692824</pmid><doi>10.1155/2020/6679029</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-4005-8605</orcidid><oa>free_for_read</oa></addata></record> |
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| recordid | cdi_swepub_primary_oai_swepub_ki_se_458076 |
| source | MEDLINE; Wiley Online Library Open Access; PubMed Central; Alma/SFX Local Collection; SWEPUB Freely available online; PubMed Central Open Access |
| subjects | Adolescent Age Anti-Bacterial Agents - therapeutic use Antibiotics Antimicrobial agents Bacteria Bacterial infections beta-Lactamases - biosynthesis Causes of Child Child, Preschool Children Communicable diseases in children Complications and side effects Culture Data collection Diagnosis Disk Diffusion Antimicrobial Tests - methods Drug resistance Drug resistance in microorganisms Drug Resistance, Bacterial Drug therapy E coli Education Enterobacteriaceae Enterobacteriaceae - isolation & purification Enterobacteriaceae - pathogenicity Enterobacteriaceae infections Enterobacteriaceae Infections - diagnosis Enterobacteriaceae Infections - microbiology Enterobacteriaceae Infections - pathology Enzymes Etiology Female Gram-negative bacteria Humans Infant Infant, Newborn Infections Laboratories Male Microbial Sensitivity Tests - methods Multidrug resistance Pediatric research Pediatrics Penicillin Pneumonia Principal components analysis Resistance factors Sample size Urinary tract Urinary tract diseases Urinary tract infections Urinary Tract Infections - diagnosis Urinary Tract Infections - microbiology Urinary Tract Infections - pathology Urine Urogenital system β Lactamase |
| title | Pediatric Febrile Urinary Tract Infection Caused by ESBL Producing Enterobacteriaceae Species |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T06%3A16%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pediatric%20Febrile%20Urinary%20Tract%20Infection%20Caused%20by%20ESBL%20Producing%20Enterobacteriaceae%20Species&rft.jtitle=BioMed%20research%20international&rft.au=Lulu,%20Birhanu&rft.date=2020&rft.volume=2020&rft.issue=2020&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2020/6679029&rft_dat=%3Cgale_swepu%3EA697105552%3C/gale_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2469680381&rft_id=info:pmid/34692824&rft_galeid=A697105552&rfr_iscdi=true |