Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome

Complex molecular programs in specific cell lineages govern human heart development. Hypoplastic left heart syndrome (HLHS) is the most common and severe manifestation within the spectrum of left ventricular outflow tract obstruction defects occurring in association with ventricular hypoplasia. The...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2021-10, Vol.144 (17), p.1409-1428
Hauptverfasser:	Krane, Markus, Dreßen, Martina, Santamaria, Gianluca, My, Ilaria, Schneider, Christine M., Dorn, Tatjana, Laue, Svenja, Mastantuono, Elisa, Berutti, Riccardo, Rawat, Hilansi, Gilsbach, Ralf, Schneider, Pedro, Lahm, Harald, Schwarz, Sascha, Doppler, Stefanie A., Paige, Sharon, Puluca, Nazan, Doll, Sophia, Neb, Irina, Brade, Thomas, Zhang, Zhong, Abou-Ajram, Claudia, Northoff, Bernd, Holdt, Lesca M., Sudhop, Stefanie, Sahara, Makoto, Goedel, Alexander, Dendorfer, Andreas, Tjong, Fleur V.Y., Rijlaarsdam, Maria E., Cleuziou, Julie, Lang, Nora, Kupatt, Christian, Bezzina, Connie, Lange, Rüdiger, Bowles, Neil E., Mann, Matthias, Gelb, Bruce D., Crotti, Lia, Hein, Lutz, Meitinger, Thomas, Wu, Sean, Sinnecker, Daniel, Gruber, Peter J., Laugwitz, Karl-Ludwig, Moretti, Alessandra
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Heterogeneity Humans Hypoplastic Left Heart Syndrome - genetics Organogenesis - genetics Original s
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