Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders

Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. W...

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Veröffentlicht in:	Nature genetics 2021-11, Vol.53 (11), p.1543-1552
Hauptverfasser:	Eijsbouts, Chris, Zheng, Tenghao, Kennedy, Nicholas A., Bonfiglio, Ferdinando, Anderson, Carl A., Moutsianas, Loukas, Holliday, Joanne, Shi, Jingchunzi, Shringarpure, Suyash, Voda, Alexandru-Ioan, Farrugia, Gianrico, Franke, Andre, Hübenthal, Matthias, Abecasis, Gonçalo, Zawistowski, Matthew, Skogholt, Anne Heidi, Ness-Jensen, Eivind, Hveem, Kristian, Esko, Tõnu, Teder-Laving, Maris, Zhernakova, Alexandra, Camilleri, Michael, Boeckxstaens, Guy, Whorwell, Peter J., Spiller, Robin, McVean, Gil, D’Amato, Mauro, Jostins, Luke, Parkes, Miles
Format:	Artikel
Sprache:	eng
Schlagworte:	38/43 631/208/205/2138 692/699/1503/1502/2071 692/699/476 Abdomen Affective disorders Aged Agriculture Animal Genetics and Genomics Antibiotics Anxiety Anxiety disorders Anxiety Disorders - genetics Biobanks Biomedical and Life Sciences Biomedicine Brain Cancer Research CD56 Antigen - genetics Cell Adhesion Molecules - genetics Clinical Medicine Constipation Cytoskeletal Proteins - genetics Diagnosis Diarrhea Digestive system Disorders Epidemiology Family medical history Female Gastroenterologi Gastroenterology and Hepatology Gastrointestinal tract Gene Function Genes Genetic aspects Genetic Predisposition to Disease Genome-wide association studies Genome-Wide Association Study Genomes Guanine Nucleotide Exchange Factors - genetics Health aspects Health risk assessment Homeodomain Proteins - genetics Human Genetics Humans Identification and classification Intestine Irritable bowel syndrome Irritable Bowel Syndrome - epidemiology Irritable Bowel Syndrome - genetics Klinisk medicin Male Medical and Health Sciences Medical Genetics and Genomics Medicin och hälsovetenskap Medicinsk genetik och genomik Mental depression Methods Middle Aged Molecular Chaperones - genetics Mood Mood Disorders - genetics Nervous system Neurosis Pain Patients Polymorphism, Single Nucleotide Quantitative trait loci Questionnaires Risk factors Signs and symptoms Twins United Kingdom - epidemiology
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