Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck
Background Insufficient preoperative work-up and consequent intralesional or marginal resection of soft-tissue sarcomas of the head and neck (STSHNs) is common. Methods This retrospective cohort study comprised 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017....
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| Veröffentlicht in: | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY 2022-06, Vol.279 (6), p.3147-3155 |
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| container_title | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY |
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| creator | Roos, Johan H. Mäkitie, Antti A. Tarkkanen, Jussi Ilmarinen, Taru T. |
| description | Background
Insufficient preoperative work-up and consequent intralesional or marginal resection of soft-tissue sarcomas of the head and neck (STSHNs) is common.
Methods
This retrospective cohort study comprised 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017. We assessed the effect of pretreatment tumor sampling on surgical margin status and need for supplemental surgery, as well as prognostic factors and survival.
Results
The lack of representative pretreatment biopsy specimen was associated with unfavorable margin status. Primary surgery at a non-academic center was associated with need for supplemental surgery. The 3-year overall survival (OS) was 68%, disease-specific survival (DSS) 71%, and recurrence-free survival (RFS) 61%. Higher tumor grade and primary tumor size over 5 cm were associated with reduced DSS.
Conclusions
Diagnosis and management of STSHNs should be centralized to experienced academic centers. Decision-making between needle biopsy, open biopsy, or upfront radical surgery depends on tumor location and size. |
| doi_str_mv | 10.1007/s00405-021-07162-0 |
| format | Article |
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Insufficient preoperative work-up and consequent intralesional or marginal resection of soft-tissue sarcomas of the head and neck (STSHNs) is common.
Methods
This retrospective cohort study comprised 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017. We assessed the effect of pretreatment tumor sampling on surgical margin status and need for supplemental surgery, as well as prognostic factors and survival.
Results
The lack of representative pretreatment biopsy specimen was associated with unfavorable margin status. Primary surgery at a non-academic center was associated with need for supplemental surgery. The 3-year overall survival (OS) was 68%, disease-specific survival (DSS) 71%, and recurrence-free survival (RFS) 61%. Higher tumor grade and primary tumor size over 5 cm were associated with reduced DSS.
Conclusions
Diagnosis and management of STSHNs should be centralized to experienced academic centers. Decision-making between needle biopsy, open biopsy, or upfront radical surgery depends on tumor location and size.</description><identifier>ISSN: 0937-4477</identifier><identifier>EISSN: 1434-4726</identifier><identifier>DOI: 10.1007/s00405-021-07162-0</identifier><identifier>PMID: 34773167</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Head and Neck ; Head and Neck Surgery ; Medicine ; Medicine & Public Health ; Neurosurgery ; Otorhinolaryngology</subject><ispartof>EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2022-06, Vol.279 (6), p.3147-3155</ispartof><rights>The Author(s) 2021. corrected publication 2021</rights><rights>2021. The Author(s).</rights><rights>The Author(s) 2021, corrected publication 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-b7d1950ce1038e4af773a8d75aea9c679e5c8441e4a6976f1f1b48f5897fc4333</citedby><cites>FETCH-LOGICAL-c484t-b7d1950ce1038e4af773a8d75aea9c679e5c8441e4a6976f1f1b48f5897fc4333</cites><orcidid>0000-0002-4895-9267</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00405-021-07162-0$$EPDF$$P50$$Gspringer$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00405-021-07162-0$$EHTML$$P50$$Gspringer$$Hfree_for_read</linktohtml><link.rule.ids>230,314,550,776,780,881,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34773167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:148120419$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Roos, Johan H.</creatorcontrib><creatorcontrib>Mäkitie, Antti A.</creatorcontrib><creatorcontrib>Tarkkanen, Jussi</creatorcontrib><creatorcontrib>Ilmarinen, Taru T.</creatorcontrib><title>Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck</title><title>EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY</title><addtitle>Eur Arch Otorhinolaryngol</addtitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><description>Background
Insufficient preoperative work-up and consequent intralesional or marginal resection of soft-tissue sarcomas of the head and neck (STSHNs) is common.
Methods
This retrospective cohort study comprised 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017. We assessed the effect of pretreatment tumor sampling on surgical margin status and need for supplemental surgery, as well as prognostic factors and survival.
Results
The lack of representative pretreatment biopsy specimen was associated with unfavorable margin status. Primary surgery at a non-academic center was associated with need for supplemental surgery. The 3-year overall survival (OS) was 68%, disease-specific survival (DSS) 71%, and recurrence-free survival (RFS) 61%. Higher tumor grade and primary tumor size over 5 cm were associated with reduced DSS.
Conclusions
Diagnosis and management of STSHNs should be centralized to experienced academic centers. Decision-making between needle biopsy, open biopsy, or upfront radical surgery depends on tumor location and size.</description><subject>Head and Neck</subject><subject>Head and Neck Surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neurosurgery</subject><subject>Otorhinolaryngology</subject><issn>0937-4477</issn><issn>1434-4726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>D8T</sourceid><recordid>eNp9UU1vFCEYJkZj1-of8GA4ekFhgGG4mJjGVpMmetAzYZmXXdoZGIGx8d_LdtfGXjxB3ueD5-VB6DWj7xil6n2hVFBJaMcIVazvCH2CNkxwQYTq-qdoQzVXRAilztCLUm4opVJo_hyd8TbjrFcbNH3LUDPYOkOsuK5zyrjYeZlC3GEbR7zktIup1OCwt66mXHCIeLE1NEHBd6HucUm-khpKWaGJs0uzxcnjuge8Bzve-0Rwty_RM2-nAq9O5zn6cfnp-8Vncv316svFx2vixCAq2aqRaUkdMMoHENa3sHYYlbRgteuVBukGIViDeq16zzzbisHLQSvvBOf8HJGjb7mDZd2aJYfZ5t8m2WBOo9t2AyOk6rlu_A9HfkNmGF3bLNvpkewxEsPe7NIvo6nqhDwYvD0Z5PRzhVLNHIqDabIR0lpMJ7USuhfDIVt3pLqcSsngH55h1BxqNcdaTavV3NdqaBO9-Tfgg-Rvj43ATxs3KO4gm5u05tg--X-2fwCULbEm</recordid><startdate>20220601</startdate><enddate>20220601</enddate><creator>Roos, Johan H.</creator><creator>Mäkitie, Antti A.</creator><creator>Tarkkanen, Jussi</creator><creator>Ilmarinen, Taru T.</creator><general>Springer Berlin Heidelberg</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0002-4895-9267</orcidid></search><sort><creationdate>20220601</creationdate><title>Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck</title><author>Roos, Johan H. ; Mäkitie, Antti A. ; Tarkkanen, Jussi ; Ilmarinen, Taru T.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-b7d1950ce1038e4af773a8d75aea9c679e5c8441e4a6976f1f1b48f5897fc4333</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Head and Neck</topic><topic>Head and Neck Surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Neurosurgery</topic><topic>Otorhinolaryngology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roos, Johan H.</creatorcontrib><creatorcontrib>Mäkitie, Antti A.</creatorcontrib><creatorcontrib>Tarkkanen, Jussi</creatorcontrib><creatorcontrib>Ilmarinen, Taru T.</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roos, Johan H.</au><au>Mäkitie, Antti A.</au><au>Tarkkanen, Jussi</au><au>Ilmarinen, Taru T.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck</atitle><jtitle>EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY</jtitle><stitle>Eur Arch Otorhinolaryngol</stitle><addtitle>Eur Arch Otorhinolaryngol</addtitle><date>2022-06-01</date><risdate>2022</risdate><volume>279</volume><issue>6</issue><spage>3147</spage><epage>3155</epage><pages>3147-3155</pages><issn>0937-4477</issn><eissn>1434-4726</eissn><abstract>Background
Insufficient preoperative work-up and consequent intralesional or marginal resection of soft-tissue sarcomas of the head and neck (STSHNs) is common.
Methods
This retrospective cohort study comprised 63 patients with STSHN treated at the Helsinki University Hospital between 2005 and 2017. We assessed the effect of pretreatment tumor sampling on surgical margin status and need for supplemental surgery, as well as prognostic factors and survival.
Results
The lack of representative pretreatment biopsy specimen was associated with unfavorable margin status. Primary surgery at a non-academic center was associated with need for supplemental surgery. The 3-year overall survival (OS) was 68%, disease-specific survival (DSS) 71%, and recurrence-free survival (RFS) 61%. Higher tumor grade and primary tumor size over 5 cm were associated with reduced DSS.
Conclusions
Diagnosis and management of STSHNs should be centralized to experienced academic centers. Decision-making between needle biopsy, open biopsy, or upfront radical surgery depends on tumor location and size.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>34773167</pmid><doi>10.1007/s00405-021-07162-0</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-4895-9267</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, 2022-06, Vol.279 (6), p.3147-3155 |
| issn | 0937-4477 1434-4726 |
| language | eng |
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| source | SWEPUB Freely available online; SpringerLink Journals - AutoHoldings |
| subjects | Head and Neck Head and Neck Surgery Medicine Medicine & Public Health Neurosurgery Otorhinolaryngology |
| title | Pretreatment tumor sampling and prognostic factors in patients with soft-tissue sarcoma of the head and neck |
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