The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials
•Folic acid supplementation reduced serum levels of CRP in adults, particularly in trials that prescribed folic acid at doses less than 5mg/d for more than 12 weeks.•Folic acid supplementation decreased serum TNF-α concentrations in adults, especially in trials that prescribed folic acid at doses 12...
Gespeichert in:
| Veröffentlicht in: | Clinical therapeutics 2021-12, Vol.43 (12), p.e346-e363 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e363 |
|---|---|
| container_issue | 12 |
| container_start_page | e346 |
| container_title | Clinical therapeutics |
| container_volume | 43 |
| creator | Zargarzadeh, Nikan Severo, Juliana Soares Pizarro, Ana Beatriz Persad, Emma Mousavi, Seyed Mohammad |
| description | •Folic acid supplementation reduced serum levels of CRP in adults, particularly in trials that prescribed folic acid at doses less than 5mg/d for more than 12 weeks.•Folic acid supplementation decreased serum TNF-α concentrations in adults, especially in trials that prescribed folic acid at doses 12 weeks.•Folic acid supplementation decreased serum IL-6 levels in adults, notably in studies administered folic acid at doses < 1mg/d and including more than 50 participants.
Despite extensive research, findings regarding the effects of folic acid supplementation on inflammatory mediators have been controversial and inconclusive. This study therefore aimed to summarize the findings of all available clinical trials regarding the effects of folic acid supplementation on inflammatory biomarkers in adults.
A systematic search was conducted of PubMed/MEDLINE, Scopus, Web of Science, EMBASE, and Google Scholar until April 2020. All randomized controlled trials that examined the influence of folic acid supplementation on C-reactive protein, interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were included. Pooled effect sizes were calculated based on the random effects model, and dose–response analysis was modeled by using a fractional polynomial model.
In total, 18 randomized controlled trials involving 2286 participants were analyzed. Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference [MD], –0.21 mg/L; 95% CI, –0.41 to –0.01; n = 16), TNF-α (MD, –14.88 pg/mL; 95% CI, –23.68 to –6.09; n = 10), and IL-6 (MD, –0.93 pg/mL; 95% CI, –1.72 to –0.14; n = 11). Subgroup analyses suggested a significant reduction at doses ≤5 mg/d and studies longer than 12 weeks in duration. A significant nonlinear association was also found between folic acid dosage (Pnonlinearity |
| doi_str_mv | 10.1016/j.clinthera.2021.10.002 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_457185</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0149291821003969</els_id><sourcerecordid>2606928206</sourcerecordid><originalsourceid>FETCH-LOGICAL-c487t-b4fc70736ea7488894522f2c5ee898ed19928bd4449ce030f130138f1751d9093</originalsourceid><addsrcrecordid>eNqFktFqFDEUhgdR7Fp9BQ14482sSSazk3i3rG0VKsp2Be9CNnOGZp2ZTJMZy_aqjyD4Aj5bn8Qz7nYFQYTAOeR8_8nh5E-SF4xOGWWz15uprV3bX0IwU045w9sppfxBMmGyUClj4svDZEKZUClXTB4lT2LcUEozlfPHyVEmZF5kSkySn6tLICdVBbaPxFfk1NfOkrl1JbkYuq6GBtre9M63BM-n4FPXVrVpGtP7sCUfoHRjFt8QQy62sQcsYIMlfHNwTUxbkrc-wt3tjyXEzrcRUNKbu9vv89bU2-h-P7pEzjfuBkqy8G0ffF1jugrO1PFp8qjCAM_28Tj5fHqyWrxLzz-evV_Mz1MrZNGna1HZghbZDEwhpJRK5JxX3OYAUkkomVJcrkshhLJAM1qxjLJMVqzIWamoyo6TdNc3XkM3rHUXXGPCVnvj9P7qK2agRV4wmSOv_sl3wZd_RPdCJmSmJM9nqH210yJ4NUDsdeOihbo2Lfghaj6jMxyX0xF9-Re68UPA3Y0UozTnWS6RKnaUDT7GANVhHEb1aBi90QfD6NEwYwENg8rn-_7DuoHyoLt3CALzHQC4fPzUoKN10Fr8-ICm0aV3_33kFymJ2mY</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2610052358</pqid></control><display><type>article</type><title>The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Zargarzadeh, Nikan ; Severo, Juliana Soares ; Pizarro, Ana Beatriz ; Persad, Emma ; Mousavi, Seyed Mohammad</creator><creatorcontrib>Zargarzadeh, Nikan ; Severo, Juliana Soares ; Pizarro, Ana Beatriz ; Persad, Emma ; Mousavi, Seyed Mohammad</creatorcontrib><description>•Folic acid supplementation reduced serum levels of CRP in adults, particularly in trials that prescribed folic acid at doses less than 5mg/d for more than 12 weeks.•Folic acid supplementation decreased serum TNF-α concentrations in adults, especially in trials that prescribed folic acid at doses <5mg/d and >12 weeks.•Folic acid supplementation decreased serum IL-6 levels in adults, notably in studies administered folic acid at doses < 1mg/d and including more than 50 participants.
Despite extensive research, findings regarding the effects of folic acid supplementation on inflammatory mediators have been controversial and inconclusive. This study therefore aimed to summarize the findings of all available clinical trials regarding the effects of folic acid supplementation on inflammatory biomarkers in adults.
A systematic search was conducted of PubMed/MEDLINE, Scopus, Web of Science, EMBASE, and Google Scholar until April 2020. All randomized controlled trials that examined the influence of folic acid supplementation on C-reactive protein, interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were included. Pooled effect sizes were calculated based on the random effects model, and dose–response analysis was modeled by using a fractional polynomial model.
In total, 18 randomized controlled trials involving 2286 participants were analyzed. Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference [MD], –0.21 mg/L; 95% CI, –0.41 to –0.01; n = 16), TNF-α (MD, –14.88 pg/mL; 95% CI, –23.68 to –6.09; n = 10), and IL-6 (MD, –0.93 pg/mL; 95% CI, –1.72 to –0.14; n = 11). Subgroup analyses suggested a significant reduction at doses ≤5 mg/d and studies longer than 12 weeks in duration. A significant nonlinear association was also found between folic acid dosage (Pnonlinearity <0.001) and duration of administration (Pnonlinearity <0.001) with serum TNF-α levels.
This meta-analysis indicates the beneficial effects of folic acid supplementation on pro-inflammatory cytokines. Further studies with a longer duration of administration, higher doses, and larger sample sizes should be performed exclusively on patients with chronic inflammatory disorders to elucidate the favorable role of folate intake on inflammatory biomarkers. International Prospective Register of Systematic Reviews identifier: CRD42021249947.</description><identifier>ISSN: 0149-2918</identifier><identifier>ISSN: 1879-114X</identifier><identifier>EISSN: 1879-114X</identifier><identifier>DOI: 10.1016/j.clinthera.2021.10.002</identifier><identifier>PMID: 34857394</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acids ; Adult ; Bias ; Biomarkers ; C-reactive protein ; Clinical trials ; cytokine ; Dietary Supplements ; folate ; Folic Acid ; Humans ; Inflammation ; Inflammation - drug therapy ; Inflammation Mediators ; Inflammatory diseases ; Interleukin 6 ; Literature reviews ; Medicin och hälsovetenskap ; Meta-analysis ; Polynomials ; Proteins ; Randomized Controlled Trials as Topic ; Serum levels ; Subgroups ; Supplements ; Systematic review ; Tumor necrosis factor-TNF ; Tumor necrosis factor-α ; Vitamin B</subject><ispartof>Clinical therapeutics, 2021-12, Vol.43 (12), p.e346-e363</ispartof><rights>2021 Elsevier Inc.</rights><rights>Copyright © 2021 Elsevier Inc. All rights reserved.</rights><rights>2021. Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c487t-b4fc70736ea7488894522f2c5ee898ed19928bd4449ce030f130138f1751d9093</citedby><cites>FETCH-LOGICAL-c487t-b4fc70736ea7488894522f2c5ee898ed19928bd4449ce030f130138f1751d9093</cites><orcidid>0000-0002-1415-2086 ; 0000-0003-4089-454X ; 0000-0003-2719-3685</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2610052358?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34857394$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:148398256$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Zargarzadeh, Nikan</creatorcontrib><creatorcontrib>Severo, Juliana Soares</creatorcontrib><creatorcontrib>Pizarro, Ana Beatriz</creatorcontrib><creatorcontrib>Persad, Emma</creatorcontrib><creatorcontrib>Mousavi, Seyed Mohammad</creatorcontrib><title>The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials</title><title>Clinical therapeutics</title><addtitle>Clin Ther</addtitle><description>•Folic acid supplementation reduced serum levels of CRP in adults, particularly in trials that prescribed folic acid at doses less than 5mg/d for more than 12 weeks.•Folic acid supplementation decreased serum TNF-α concentrations in adults, especially in trials that prescribed folic acid at doses <5mg/d and >12 weeks.•Folic acid supplementation decreased serum IL-6 levels in adults, notably in studies administered folic acid at doses < 1mg/d and including more than 50 participants.
Despite extensive research, findings regarding the effects of folic acid supplementation on inflammatory mediators have been controversial and inconclusive. This study therefore aimed to summarize the findings of all available clinical trials regarding the effects of folic acid supplementation on inflammatory biomarkers in adults.
A systematic search was conducted of PubMed/MEDLINE, Scopus, Web of Science, EMBASE, and Google Scholar until April 2020. All randomized controlled trials that examined the influence of folic acid supplementation on C-reactive protein, interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were included. Pooled effect sizes were calculated based on the random effects model, and dose–response analysis was modeled by using a fractional polynomial model.
In total, 18 randomized controlled trials involving 2286 participants were analyzed. Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference [MD], –0.21 mg/L; 95% CI, –0.41 to –0.01; n = 16), TNF-α (MD, –14.88 pg/mL; 95% CI, –23.68 to –6.09; n = 10), and IL-6 (MD, –0.93 pg/mL; 95% CI, –1.72 to –0.14; n = 11). Subgroup analyses suggested a significant reduction at doses ≤5 mg/d and studies longer than 12 weeks in duration. A significant nonlinear association was also found between folic acid dosage (Pnonlinearity <0.001) and duration of administration (Pnonlinearity <0.001) with serum TNF-α levels.
This meta-analysis indicates the beneficial effects of folic acid supplementation on pro-inflammatory cytokines. Further studies with a longer duration of administration, higher doses, and larger sample sizes should be performed exclusively on patients with chronic inflammatory disorders to elucidate the favorable role of folate intake on inflammatory biomarkers. International Prospective Register of Systematic Reviews identifier: CRD42021249947.</description><subject>Acids</subject><subject>Adult</subject><subject>Bias</subject><subject>Biomarkers</subject><subject>C-reactive protein</subject><subject>Clinical trials</subject><subject>cytokine</subject><subject>Dietary Supplements</subject><subject>folate</subject><subject>Folic Acid</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - drug therapy</subject><subject>Inflammation Mediators</subject><subject>Inflammatory diseases</subject><subject>Interleukin 6</subject><subject>Literature reviews</subject><subject>Medicin och hälsovetenskap</subject><subject>Meta-analysis</subject><subject>Polynomials</subject><subject>Proteins</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Serum levels</subject><subject>Subgroups</subject><subject>Supplements</subject><subject>Systematic review</subject><subject>Tumor necrosis factor-TNF</subject><subject>Tumor necrosis factor-α</subject><subject>Vitamin B</subject><issn>0149-2918</issn><issn>1879-114X</issn><issn>1879-114X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFktFqFDEUhgdR7Fp9BQ14482sSSazk3i3rG0VKsp2Be9CNnOGZp2ZTJMZy_aqjyD4Aj5bn8Qz7nYFQYTAOeR8_8nh5E-SF4xOGWWz15uprV3bX0IwU045w9sppfxBMmGyUClj4svDZEKZUClXTB4lT2LcUEozlfPHyVEmZF5kSkySn6tLICdVBbaPxFfk1NfOkrl1JbkYuq6GBtre9M63BM-n4FPXVrVpGtP7sCUfoHRjFt8QQy62sQcsYIMlfHNwTUxbkrc-wt3tjyXEzrcRUNKbu9vv89bU2-h-P7pEzjfuBkqy8G0ffF1jugrO1PFp8qjCAM_28Tj5fHqyWrxLzz-evV_Mz1MrZNGna1HZghbZDEwhpJRK5JxX3OYAUkkomVJcrkshhLJAM1qxjLJMVqzIWamoyo6TdNc3XkM3rHUXXGPCVnvj9P7qK2agRV4wmSOv_sl3wZd_RPdCJmSmJM9nqH210yJ4NUDsdeOihbo2Lfghaj6jMxyX0xF9-Re68UPA3Y0UozTnWS6RKnaUDT7GANVhHEb1aBi90QfD6NEwYwENg8rn-_7DuoHyoLt3CALzHQC4fPzUoKN10Fr8-ICm0aV3_33kFymJ2mY</recordid><startdate>20211201</startdate><enddate>20211201</enddate><creator>Zargarzadeh, Nikan</creator><creator>Severo, Juliana Soares</creator><creator>Pizarro, Ana Beatriz</creator><creator>Persad, Emma</creator><creator>Mousavi, Seyed Mohammad</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88C</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M0T</scope><scope>M1P</scope><scope>M2O</scope><scope>M7N</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>ADTPV</scope><scope>AOWAS</scope><orcidid>https://orcid.org/0000-0002-1415-2086</orcidid><orcidid>https://orcid.org/0000-0003-4089-454X</orcidid><orcidid>https://orcid.org/0000-0003-2719-3685</orcidid></search><sort><creationdate>20211201</creationdate><title>The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials</title><author>Zargarzadeh, Nikan ; Severo, Juliana Soares ; Pizarro, Ana Beatriz ; Persad, Emma ; Mousavi, Seyed Mohammad</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c487t-b4fc70736ea7488894522f2c5ee898ed19928bd4449ce030f130138f1751d9093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Acids</topic><topic>Adult</topic><topic>Bias</topic><topic>Biomarkers</topic><topic>C-reactive protein</topic><topic>Clinical trials</topic><topic>cytokine</topic><topic>Dietary Supplements</topic><topic>folate</topic><topic>Folic Acid</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - drug therapy</topic><topic>Inflammation Mediators</topic><topic>Inflammatory diseases</topic><topic>Interleukin 6</topic><topic>Literature reviews</topic><topic>Medicin och hälsovetenskap</topic><topic>Meta-analysis</topic><topic>Polynomials</topic><topic>Proteins</topic><topic>Randomized Controlled Trials as Topic</topic><topic>Serum levels</topic><topic>Subgroups</topic><topic>Supplements</topic><topic>Systematic review</topic><topic>Tumor necrosis factor-TNF</topic><topic>Tumor necrosis factor-α</topic><topic>Vitamin B</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zargarzadeh, Nikan</creatorcontrib><creatorcontrib>Severo, Juliana Soares</creatorcontrib><creatorcontrib>Pizarro, Ana Beatriz</creatorcontrib><creatorcontrib>Persad, Emma</creatorcontrib><creatorcontrib>Mousavi, Seyed Mohammad</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Healthcare Administration Database (Alumni)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Healthcare Administration Database</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>SwePub</collection><collection>SwePub Articles</collection><jtitle>Clinical therapeutics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zargarzadeh, Nikan</au><au>Severo, Juliana Soares</au><au>Pizarro, Ana Beatriz</au><au>Persad, Emma</au><au>Mousavi, Seyed Mohammad</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials</atitle><jtitle>Clinical therapeutics</jtitle><addtitle>Clin Ther</addtitle><date>2021-12-01</date><risdate>2021</risdate><volume>43</volume><issue>12</issue><spage>e346</spage><epage>e363</epage><pages>e346-e363</pages><issn>0149-2918</issn><issn>1879-114X</issn><eissn>1879-114X</eissn><abstract>•Folic acid supplementation reduced serum levels of CRP in adults, particularly in trials that prescribed folic acid at doses less than 5mg/d for more than 12 weeks.•Folic acid supplementation decreased serum TNF-α concentrations in adults, especially in trials that prescribed folic acid at doses <5mg/d and >12 weeks.•Folic acid supplementation decreased serum IL-6 levels in adults, notably in studies administered folic acid at doses < 1mg/d and including more than 50 participants.
Despite extensive research, findings regarding the effects of folic acid supplementation on inflammatory mediators have been controversial and inconclusive. This study therefore aimed to summarize the findings of all available clinical trials regarding the effects of folic acid supplementation on inflammatory biomarkers in adults.
A systematic search was conducted of PubMed/MEDLINE, Scopus, Web of Science, EMBASE, and Google Scholar until April 2020. All randomized controlled trials that examined the influence of folic acid supplementation on C-reactive protein, interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α) were included. Pooled effect sizes were calculated based on the random effects model, and dose–response analysis was modeled by using a fractional polynomial model.
In total, 18 randomized controlled trials involving 2286 participants were analyzed. Folic acid supplementation significantly reduced serum levels of C-reactive protein (mean difference [MD], –0.21 mg/L; 95% CI, –0.41 to –0.01; n = 16), TNF-α (MD, –14.88 pg/mL; 95% CI, –23.68 to –6.09; n = 10), and IL-6 (MD, –0.93 pg/mL; 95% CI, –1.72 to –0.14; n = 11). Subgroup analyses suggested a significant reduction at doses ≤5 mg/d and studies longer than 12 weeks in duration. A significant nonlinear association was also found between folic acid dosage (Pnonlinearity <0.001) and duration of administration (Pnonlinearity <0.001) with serum TNF-α levels.
This meta-analysis indicates the beneficial effects of folic acid supplementation on pro-inflammatory cytokines. Further studies with a longer duration of administration, higher doses, and larger sample sizes should be performed exclusively on patients with chronic inflammatory disorders to elucidate the favorable role of folate intake on inflammatory biomarkers. International Prospective Register of Systematic Reviews identifier: CRD42021249947.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>34857394</pmid><doi>10.1016/j.clinthera.2021.10.002</doi><orcidid>https://orcid.org/0000-0002-1415-2086</orcidid><orcidid>https://orcid.org/0000-0003-4089-454X</orcidid><orcidid>https://orcid.org/0000-0003-2719-3685</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0149-2918 |
| ispartof | Clinical therapeutics, 2021-12, Vol.43 (12), p.e346-e363 |
| issn | 0149-2918 1879-114X 1879-114X |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_457185 |
| source | MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland |
| subjects | Acids Adult Bias Biomarkers C-reactive protein Clinical trials cytokine Dietary Supplements folate Folic Acid Humans Inflammation Inflammation - drug therapy Inflammation Mediators Inflammatory diseases Interleukin 6 Literature reviews Medicin och hälsovetenskap Meta-analysis Polynomials Proteins Randomized Controlled Trials as Topic Serum levels Subgroups Supplements Systematic review Tumor necrosis factor-TNF Tumor necrosis factor-α Vitamin B |
| title | The Effects of Folic Acid Supplementation on Pro-inflammatory Mediators: a Systematic Review and Dose–Response Meta‐Analysis of Randomized Controlled Trials |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T20%3A32%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20Effects%20of%20Folic%20Acid%20Supplementation%20on%20Pro-inflammatory%20Mediators:%20a%20Systematic%20Review%20and%20Dose%E2%80%93Response%20Meta%E2%80%90Analysis%20of%20Randomized%20Controlled%20Trials&rft.jtitle=Clinical%20therapeutics&rft.au=Zargarzadeh,%20Nikan&rft.date=2021-12-01&rft.volume=43&rft.issue=12&rft.spage=e346&rft.epage=e363&rft.pages=e346-e363&rft.issn=0149-2918&rft.eissn=1879-114X&rft_id=info:doi/10.1016/j.clinthera.2021.10.002&rft_dat=%3Cproquest_swepu%3E2606928206%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2610052358&rft_id=info:pmid/34857394&rft_els_id=S0149291821003969&rfr_iscdi=true |