Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta‐analysis
Children with autism spectrum disorder (ASD) are frequently diagnosed with co‐occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random‐effects meta‐analysis. We s...
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| Veröffentlicht in: | Autism research 2022-02, Vol.15 (2), p.340-352 |
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| creator | Kim, Jong Yeob Choi, Min Je Ha, Sungji Hwang, Jimin Koyanagi, Ai Dragioti, Elena Radua, Joaquim Smith, Lee Jacob, Louis Pablo, Gonzalo Salazar Lee, Seung Won Yon, Dong Keon Thompson, Trevor Cortese, Samuele Lollo, Gianluca Liang, Chih‐Sung Chu, Che‐Sheng Fusar‐Poli, Paolo Cheon, Keun‐Ah Shin, Jae Il Solmi, Marco |
| description | Children with autism spectrum disorder (ASD) are frequently diagnosed with co‐occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random‐effects meta‐analysis. We searched PubMed, Embase, and PsycInfo (last search on January 25, 2021), and manually searched relevant publications. We included observational studies measuring the association between ASD and IBD. The primary outcome was the association (odds ratio, OR) between ASD and later development of IBD. Sensitivity analyses were conducted by quality, confounding adjustment, and study design. We performed meta‐regression analyses and assessed heterogeneity, publication bias, and quality of studies with the Newcastle‐Ottawa Scale. Overall, we included six studies consisting of eight datasets, including over 11 million participants. We found that ASD was significantly associated with subsequent incident IBD (any IBD, OR = 1.66, 95% confidence interval[CI] = 1.25–2.21, p |
| doi_str_mv | 10.1002/aur.2656 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_swepub_ki_se_456738</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2625932285</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4936-60b98a9f7eccd9d29dc8cc2d85346cef7125c88e86232ad84c2c4c0ceb8b0b133</originalsourceid><addsrcrecordid>eNp9kctu1TAQhi0EoqUg8QTIEpuySPEl8XHYReVSpCMhIcrWcuwJuCTxwXYaZccj8Iw8CU7PaRELWHk08_nT2D9CTyk5o4Swl3oKZ0xU4h46pjWvCy6JuH9bb2p2hB7FeEWIILxiD9ERL_OEV_wYpSZGb5xOzo-4hTQDjFhPycUBxx2YFKYBWxd9sBCwHi12Y9frYdDJhwW3foZ-nYOO8Ao3OC4xQR46gwNcO5hv7gyQ9K8fP_Wo-yW6-Bg96HQf4cnhPEGXb998Or8oth_evT9vtoXJ-4lCkLaWuu42YIytLautkcYwKyteCgPdhrLKSAlSMM60laVhpjTEQCtb0lLOT1Cx98YZdlOrdsENOizKa6cOrW-5AlVWYsPlf_nX7nOjfPiiejcpKhkRVeZf7Pmvuv8Lvmi2au0RLkhJKbmmmX2-Z3fBf58gJnXlp5A_JComWFVzxuRqPN1TJvgYA3R3WkrUGrXKUas16ow-OwindgB7B95m--c1s-th-adINZcfb4S_AVngtag</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2625932285</pqid></control><display><type>article</type><title>Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta‐analysis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>SWEPUB Freely available online</source><creator>Kim, Jong Yeob ; Choi, Min Je ; Ha, Sungji ; Hwang, Jimin ; Koyanagi, Ai ; Dragioti, Elena ; Radua, Joaquim ; Smith, Lee ; Jacob, Louis ; Pablo, Gonzalo Salazar ; Lee, Seung Won ; Yon, Dong Keon ; Thompson, Trevor ; Cortese, Samuele ; Lollo, Gianluca ; Liang, Chih‐Sung ; Chu, Che‐Sheng ; Fusar‐Poli, Paolo ; Cheon, Keun‐Ah ; Shin, Jae Il ; Solmi, Marco</creator><creatorcontrib>Kim, Jong Yeob ; Choi, Min Je ; Ha, Sungji ; Hwang, Jimin ; Koyanagi, Ai ; Dragioti, Elena ; Radua, Joaquim ; Smith, Lee ; Jacob, Louis ; Pablo, Gonzalo Salazar ; Lee, Seung Won ; Yon, Dong Keon ; Thompson, Trevor ; Cortese, Samuele ; Lollo, Gianluca ; Liang, Chih‐Sung ; Chu, Che‐Sheng ; Fusar‐Poli, Paolo ; Cheon, Keun‐Ah ; Shin, Jae Il ; Solmi, Marco</creatorcontrib><description>Children with autism spectrum disorder (ASD) are frequently diagnosed with co‐occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random‐effects meta‐analysis. We searched PubMed, Embase, and PsycInfo (last search on January 25, 2021), and manually searched relevant publications. We included observational studies measuring the association between ASD and IBD. The primary outcome was the association (odds ratio, OR) between ASD and later development of IBD. Sensitivity analyses were conducted by quality, confounding adjustment, and study design. We performed meta‐regression analyses and assessed heterogeneity, publication bias, and quality of studies with the Newcastle‐Ottawa Scale. Overall, we included six studies consisting of eight datasets, including over 11 million participants. We found that ASD was significantly associated with subsequent incident IBD (any IBD, OR = 1.66, 95% confidence interval[CI] = 1.25–2.21, p < 0.001; ulcerative colitis, OR = 1.91, 95%CI = 1.41–2.6, p < 0.001; Crohn's disease, OR = 1.47, 95%CI = 1.15–1.88, p = 0.002). ASD and IBD were also associated regardless of temporal sequence of diagnosis (any IBD, OR = 1.57, 95%CI = 1.28–1.93, p < 0.001; ulcerative colitis, OR = 1.7, 95%CI = 1.36–2.12, p < 0.001; Crohn's disease, OR = 1.37, 95%CI = 1.12–1.69, p = 0.003). Sensitivity analyses confirmed the findings of the main analysis. Meta‐regression did not identify any significant moderators. Publication bias was not detected. Quality was high in four datasets and medium in four. In conclusion, our findings highlight the need to screen for IBD in individuals with ASD, and future research should identify who, among those with ASD, has the highest risk of IBD, and elucidate the shared biological mechanisms between ASD and IBD.
Lay Summary
This systematic review and meta‐analysis of eight observational datasets found that individuals with autism spectrum disorder (ASD) are more likely to develop any inflammatory bowel disease, ulcerative colitis, or Crohn's disease. Our findings highlight the need to screen for inflammatory bowel disease in patients with ASD and elucidate the shared biological mechanisms between the two disorders.</description><identifier>ISSN: 1939-3792</identifier><identifier>ISSN: 1939-3806</identifier><identifier>EISSN: 1939-3806</identifier><identifier>DOI: 10.1002/aur.2656</identifier><identifier>PMID: 34939353</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Autism ; autism spectrum disorder ; Autism Spectrum Disorder - complications ; Autism Spectrum Disorder - epidemiology ; Bias ; Child ; Chronic Disease ; Confidence intervals ; Crohn's disease ; Datasets ; Heterogeneity ; Humans ; Inflammatory bowel disease ; Inflammatory bowel diseases ; Inflammatory Bowel Diseases - complications ; Inflammatory Bowel Diseases - epidemiology ; Intestine ; Life Sciences ; Meta-analysis ; Moderators ; Observational Studies as Topic ; Odds Ratio ; Regression analysis ; Sensitivity analysis ; Statistical analysis ; Systematic review ; Ulcerative colitis</subject><ispartof>Autism research, 2022-02, Vol.15 (2), p.340-352</ispartof><rights>2021 International Society for Autism Research and Wiley Periodicals LLC.</rights><rights>2022 International Society for Autism Research and Wiley Periodicals LLC.</rights><rights>Copyright</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4936-60b98a9f7eccd9d29dc8cc2d85346cef7125c88e86232ad84c2c4c0ceb8b0b133</citedby><cites>FETCH-LOGICAL-c4936-60b98a9f7eccd9d29dc8cc2d85346cef7125c88e86232ad84c2c4c0ceb8b0b133</cites><orcidid>0000-0003-4756-9440 ; 0000-0003-2326-1820 ; 0000-0001-8790-9708 ; 0000-0001-9880-782X ; 0000-0003-1240-5438 ; 0000-0002-5340-9833 ; 0000-0001-5632-5208 ; 0000-0002-9565-5004 ; 0000-0003-4877-7233 ; 0000-0003-1628-9948</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Faur.2656$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Faur.2656$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,550,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34939353$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-03604110$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-182065$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:148423815$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Jong Yeob</creatorcontrib><creatorcontrib>Choi, Min Je</creatorcontrib><creatorcontrib>Ha, Sungji</creatorcontrib><creatorcontrib>Hwang, Jimin</creatorcontrib><creatorcontrib>Koyanagi, Ai</creatorcontrib><creatorcontrib>Dragioti, Elena</creatorcontrib><creatorcontrib>Radua, Joaquim</creatorcontrib><creatorcontrib>Smith, Lee</creatorcontrib><creatorcontrib>Jacob, Louis</creatorcontrib><creatorcontrib>Pablo, Gonzalo Salazar</creatorcontrib><creatorcontrib>Lee, Seung Won</creatorcontrib><creatorcontrib>Yon, Dong Keon</creatorcontrib><creatorcontrib>Thompson, Trevor</creatorcontrib><creatorcontrib>Cortese, Samuele</creatorcontrib><creatorcontrib>Lollo, Gianluca</creatorcontrib><creatorcontrib>Liang, Chih‐Sung</creatorcontrib><creatorcontrib>Chu, Che‐Sheng</creatorcontrib><creatorcontrib>Fusar‐Poli, Paolo</creatorcontrib><creatorcontrib>Cheon, Keun‐Ah</creatorcontrib><creatorcontrib>Shin, Jae Il</creatorcontrib><creatorcontrib>Solmi, Marco</creatorcontrib><title>Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta‐analysis</title><title>Autism research</title><addtitle>Autism Res</addtitle><description>Children with autism spectrum disorder (ASD) are frequently diagnosed with co‐occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random‐effects meta‐analysis. We searched PubMed, Embase, and PsycInfo (last search on January 25, 2021), and manually searched relevant publications. We included observational studies measuring the association between ASD and IBD. The primary outcome was the association (odds ratio, OR) between ASD and later development of IBD. Sensitivity analyses were conducted by quality, confounding adjustment, and study design. We performed meta‐regression analyses and assessed heterogeneity, publication bias, and quality of studies with the Newcastle‐Ottawa Scale. Overall, we included six studies consisting of eight datasets, including over 11 million participants. We found that ASD was significantly associated with subsequent incident IBD (any IBD, OR = 1.66, 95% confidence interval[CI] = 1.25–2.21, p < 0.001; ulcerative colitis, OR = 1.91, 95%CI = 1.41–2.6, p < 0.001; Crohn's disease, OR = 1.47, 95%CI = 1.15–1.88, p = 0.002). ASD and IBD were also associated regardless of temporal sequence of diagnosis (any IBD, OR = 1.57, 95%CI = 1.28–1.93, p < 0.001; ulcerative colitis, OR = 1.7, 95%CI = 1.36–2.12, p < 0.001; Crohn's disease, OR = 1.37, 95%CI = 1.12–1.69, p = 0.003). Sensitivity analyses confirmed the findings of the main analysis. Meta‐regression did not identify any significant moderators. Publication bias was not detected. Quality was high in four datasets and medium in four. In conclusion, our findings highlight the need to screen for IBD in individuals with ASD, and future research should identify who, among those with ASD, has the highest risk of IBD, and elucidate the shared biological mechanisms between ASD and IBD.
Lay Summary
This systematic review and meta‐analysis of eight observational datasets found that individuals with autism spectrum disorder (ASD) are more likely to develop any inflammatory bowel disease, ulcerative colitis, or Crohn's disease. Our findings highlight the need to screen for inflammatory bowel disease in patients with ASD and elucidate the shared biological mechanisms between the two disorders.</description><subject>Autism</subject><subject>autism spectrum disorder</subject><subject>Autism Spectrum Disorder - complications</subject><subject>Autism Spectrum Disorder - epidemiology</subject><subject>Bias</subject><subject>Child</subject><subject>Chronic Disease</subject><subject>Confidence intervals</subject><subject>Crohn's disease</subject><subject>Datasets</subject><subject>Heterogeneity</subject><subject>Humans</subject><subject>Inflammatory bowel disease</subject><subject>Inflammatory bowel diseases</subject><subject>Inflammatory Bowel Diseases - complications</subject><subject>Inflammatory Bowel Diseases - epidemiology</subject><subject>Intestine</subject><subject>Life Sciences</subject><subject>Meta-analysis</subject><subject>Moderators</subject><subject>Observational Studies as Topic</subject><subject>Odds Ratio</subject><subject>Regression analysis</subject><subject>Sensitivity analysis</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><subject>Ulcerative colitis</subject><issn>1939-3792</issn><issn>1939-3806</issn><issn>1939-3806</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9kctu1TAQhi0EoqUg8QTIEpuySPEl8XHYReVSpCMhIcrWcuwJuCTxwXYaZccj8Iw8CU7PaRELWHk08_nT2D9CTyk5o4Swl3oKZ0xU4h46pjWvCy6JuH9bb2p2hB7FeEWIILxiD9ERL_OEV_wYpSZGb5xOzo-4hTQDjFhPycUBxx2YFKYBWxd9sBCwHi12Y9frYdDJhwW3foZ-nYOO8Ao3OC4xQR46gwNcO5hv7gyQ9K8fP_Wo-yW6-Bg96HQf4cnhPEGXb998Or8oth_evT9vtoXJ-4lCkLaWuu42YIytLautkcYwKyteCgPdhrLKSAlSMM60laVhpjTEQCtb0lLOT1Cx98YZdlOrdsENOizKa6cOrW-5AlVWYsPlf_nX7nOjfPiiejcpKhkRVeZf7Pmvuv8Lvmi2au0RLkhJKbmmmX2-Z3fBf58gJnXlp5A_JComWFVzxuRqPN1TJvgYA3R3WkrUGrXKUas16ow-OwindgB7B95m--c1s-th-adINZcfb4S_AVngtag</recordid><startdate>202202</startdate><enddate>202202</enddate><creator>Kim, Jong Yeob</creator><creator>Choi, Min Je</creator><creator>Ha, Sungji</creator><creator>Hwang, Jimin</creator><creator>Koyanagi, Ai</creator><creator>Dragioti, Elena</creator><creator>Radua, Joaquim</creator><creator>Smith, Lee</creator><creator>Jacob, Louis</creator><creator>Pablo, Gonzalo Salazar</creator><creator>Lee, Seung Won</creator><creator>Yon, Dong Keon</creator><creator>Thompson, Trevor</creator><creator>Cortese, Samuele</creator><creator>Lollo, Gianluca</creator><creator>Liang, Chih‐Sung</creator><creator>Chu, Che‐Sheng</creator><creator>Fusar‐Poli, Paolo</creator><creator>Cheon, Keun‐Ah</creator><creator>Shin, Jae Il</creator><creator>Solmi, Marco</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><general>International Society for Autism Research, Wiley Periodicals, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>1XC</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG8</scope><scope>D8T</scope><scope>ZZAVC</scope><orcidid>https://orcid.org/0000-0003-4756-9440</orcidid><orcidid>https://orcid.org/0000-0003-2326-1820</orcidid><orcidid>https://orcid.org/0000-0001-8790-9708</orcidid><orcidid>https://orcid.org/0000-0001-9880-782X</orcidid><orcidid>https://orcid.org/0000-0003-1240-5438</orcidid><orcidid>https://orcid.org/0000-0002-5340-9833</orcidid><orcidid>https://orcid.org/0000-0001-5632-5208</orcidid><orcidid>https://orcid.org/0000-0002-9565-5004</orcidid><orcidid>https://orcid.org/0000-0003-4877-7233</orcidid><orcidid>https://orcid.org/0000-0003-1628-9948</orcidid></search><sort><creationdate>202202</creationdate><title>Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta‐analysis</title><author>Kim, Jong Yeob ; Choi, Min Je ; Ha, Sungji ; Hwang, Jimin ; Koyanagi, Ai ; Dragioti, Elena ; Radua, Joaquim ; Smith, Lee ; Jacob, Louis ; Pablo, Gonzalo Salazar ; Lee, Seung Won ; Yon, Dong Keon ; Thompson, Trevor ; Cortese, Samuele ; Lollo, Gianluca ; Liang, Chih‐Sung ; Chu, Che‐Sheng ; Fusar‐Poli, Paolo ; Cheon, Keun‐Ah ; Shin, Jae Il ; Solmi, Marco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4936-60b98a9f7eccd9d29dc8cc2d85346cef7125c88e86232ad84c2c4c0ceb8b0b133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Autism</topic><topic>autism spectrum disorder</topic><topic>Autism Spectrum Disorder - complications</topic><topic>Autism Spectrum Disorder - epidemiology</topic><topic>Bias</topic><topic>Child</topic><topic>Chronic Disease</topic><topic>Confidence intervals</topic><topic>Crohn's disease</topic><topic>Datasets</topic><topic>Heterogeneity</topic><topic>Humans</topic><topic>Inflammatory bowel disease</topic><topic>Inflammatory bowel diseases</topic><topic>Inflammatory Bowel Diseases - complications</topic><topic>Inflammatory Bowel Diseases - epidemiology</topic><topic>Intestine</topic><topic>Life Sciences</topic><topic>Meta-analysis</topic><topic>Moderators</topic><topic>Observational Studies as Topic</topic><topic>Odds Ratio</topic><topic>Regression analysis</topic><topic>Sensitivity analysis</topic><topic>Statistical analysis</topic><topic>Systematic review</topic><topic>Ulcerative colitis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Jong Yeob</creatorcontrib><creatorcontrib>Choi, Min Je</creatorcontrib><creatorcontrib>Ha, Sungji</creatorcontrib><creatorcontrib>Hwang, Jimin</creatorcontrib><creatorcontrib>Koyanagi, Ai</creatorcontrib><creatorcontrib>Dragioti, Elena</creatorcontrib><creatorcontrib>Radua, Joaquim</creatorcontrib><creatorcontrib>Smith, Lee</creatorcontrib><creatorcontrib>Jacob, Louis</creatorcontrib><creatorcontrib>Pablo, Gonzalo Salazar</creatorcontrib><creatorcontrib>Lee, Seung Won</creatorcontrib><creatorcontrib>Yon, Dong Keon</creatorcontrib><creatorcontrib>Thompson, Trevor</creatorcontrib><creatorcontrib>Cortese, Samuele</creatorcontrib><creatorcontrib>Lollo, Gianluca</creatorcontrib><creatorcontrib>Liang, Chih‐Sung</creatorcontrib><creatorcontrib>Chu, Che‐Sheng</creatorcontrib><creatorcontrib>Fusar‐Poli, Paolo</creatorcontrib><creatorcontrib>Cheon, Keun‐Ah</creatorcontrib><creatorcontrib>Shin, Jae Il</creatorcontrib><creatorcontrib>Solmi, Marco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Linköpings universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>Autism research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Jong Yeob</au><au>Choi, Min Je</au><au>Ha, Sungji</au><au>Hwang, Jimin</au><au>Koyanagi, Ai</au><au>Dragioti, Elena</au><au>Radua, Joaquim</au><au>Smith, Lee</au><au>Jacob, Louis</au><au>Pablo, Gonzalo Salazar</au><au>Lee, Seung Won</au><au>Yon, Dong Keon</au><au>Thompson, Trevor</au><au>Cortese, Samuele</au><au>Lollo, Gianluca</au><au>Liang, Chih‐Sung</au><au>Chu, Che‐Sheng</au><au>Fusar‐Poli, Paolo</au><au>Cheon, Keun‐Ah</au><au>Shin, Jae Il</au><au>Solmi, Marco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta‐analysis</atitle><jtitle>Autism research</jtitle><addtitle>Autism Res</addtitle><date>2022-02</date><risdate>2022</risdate><volume>15</volume><issue>2</issue><spage>340</spage><epage>352</epage><pages>340-352</pages><issn>1939-3792</issn><issn>1939-3806</issn><eissn>1939-3806</eissn><abstract>Children with autism spectrum disorder (ASD) are frequently diagnosed with co‐occurring medical conditions including inflammatory bowel disease (IBD). To investigate the association, we conducted a systematic review registered in PROSPERO (ID:CRD42021236263) with a random‐effects meta‐analysis. We searched PubMed, Embase, and PsycInfo (last search on January 25, 2021), and manually searched relevant publications. We included observational studies measuring the association between ASD and IBD. The primary outcome was the association (odds ratio, OR) between ASD and later development of IBD. Sensitivity analyses were conducted by quality, confounding adjustment, and study design. We performed meta‐regression analyses and assessed heterogeneity, publication bias, and quality of studies with the Newcastle‐Ottawa Scale. Overall, we included six studies consisting of eight datasets, including over 11 million participants. We found that ASD was significantly associated with subsequent incident IBD (any IBD, OR = 1.66, 95% confidence interval[CI] = 1.25–2.21, p < 0.001; ulcerative colitis, OR = 1.91, 95%CI = 1.41–2.6, p < 0.001; Crohn's disease, OR = 1.47, 95%CI = 1.15–1.88, p = 0.002). ASD and IBD were also associated regardless of temporal sequence of diagnosis (any IBD, OR = 1.57, 95%CI = 1.28–1.93, p < 0.001; ulcerative colitis, OR = 1.7, 95%CI = 1.36–2.12, p < 0.001; Crohn's disease, OR = 1.37, 95%CI = 1.12–1.69, p = 0.003). Sensitivity analyses confirmed the findings of the main analysis. Meta‐regression did not identify any significant moderators. Publication bias was not detected. Quality was high in four datasets and medium in four. In conclusion, our findings highlight the need to screen for IBD in individuals with ASD, and future research should identify who, among those with ASD, has the highest risk of IBD, and elucidate the shared biological mechanisms between ASD and IBD.
Lay Summary
This systematic review and meta‐analysis of eight observational datasets found that individuals with autism spectrum disorder (ASD) are more likely to develop any inflammatory bowel disease, ulcerative colitis, or Crohn's disease. Our findings highlight the need to screen for inflammatory bowel disease in patients with ASD and elucidate the shared biological mechanisms between the two disorders.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>34939353</pmid><doi>10.1002/aur.2656</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4756-9440</orcidid><orcidid>https://orcid.org/0000-0003-2326-1820</orcidid><orcidid>https://orcid.org/0000-0001-8790-9708</orcidid><orcidid>https://orcid.org/0000-0001-9880-782X</orcidid><orcidid>https://orcid.org/0000-0003-1240-5438</orcidid><orcidid>https://orcid.org/0000-0002-5340-9833</orcidid><orcidid>https://orcid.org/0000-0001-5632-5208</orcidid><orcidid>https://orcid.org/0000-0002-9565-5004</orcidid><orcidid>https://orcid.org/0000-0003-4877-7233</orcidid><orcidid>https://orcid.org/0000-0003-1628-9948</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1939-3792 |
| ispartof | Autism research, 2022-02, Vol.15 (2), p.340-352 |
| issn | 1939-3792 1939-3806 1939-3806 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_456738 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online |
| subjects | Autism autism spectrum disorder Autism Spectrum Disorder - complications Autism Spectrum Disorder - epidemiology Bias Child Chronic Disease Confidence intervals Crohn's disease Datasets Heterogeneity Humans Inflammatory bowel disease Inflammatory bowel diseases Inflammatory Bowel Diseases - complications Inflammatory Bowel Diseases - epidemiology Intestine Life Sciences Meta-analysis Moderators Observational Studies as Topic Odds Ratio Regression analysis Sensitivity analysis Statistical analysis Systematic review Ulcerative colitis |
| title | Association between autism spectrum disorder and inflammatory bowel disease: A systematic review and meta‐analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T14%3A53%3A08IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_swepu&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Association%20between%20autism%20spectrum%20disorder%20and%20inflammatory%20bowel%20disease:%20A%20systematic%20review%20and%20meta%E2%80%90analysis&rft.jtitle=Autism%20research&rft.au=Kim,%20Jong%20Yeob&rft.date=2022-02&rft.volume=15&rft.issue=2&rft.spage=340&rft.epage=352&rft.pages=340-352&rft.issn=1939-3792&rft.eissn=1939-3806&rft_id=info:doi/10.1002/aur.2656&rft_dat=%3Cproquest_swepu%3E2625932285%3C/proquest_swepu%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2625932285&rft_id=info:pmid/34939353&rfr_iscdi=true |