Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019
IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 c...
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| Veröffentlicht in: | JAMA oncology 2022-03, Vol.8 (3), p.420-444 |
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| creator | Afzal, Muhammad Sohail Ahmad, Tauseef Alahdab, Fares Al-Aly, Ziyad Ali, Saqib Aljunid, Syed Mohamed Al-Maweri, Sadeq Ali Ali Anbesu, Etsay Woldu Antwi, Maxwell Hubert Aqeel, Muhammad Arabloo, Jalal Arab-Zozani, Morteza Artaman, Al Ayenew, Temesgen Badiye, Ashish D Baig, Atif Amin Balakrishnan, Senthilkumar Barra, Fabio Bezabhe, Woldesellassie M. Mequanint Bezabih, Yihienew Mequanint Bhardwaj, Nikha Bhattacharyya, Krittika Bjørge, Tone Catalá-López, Ferrán Cernigliaro, Achille Chaturvedi, Pankaj Chung, Michael T Costa, Vera Marisa das Neves, José Dhimal, Meghnath Eftekharzadeh, Sahar Ezzikouri, Sayeh Ferro Desideri, Lorenzo Foroutan, Masoud Fukumoto, Takeshi Gaal, Peter Andras Gallus, Silvano Glasbey, James C Goleij, Pouya Goudarzi, Houman Gubari, Mohammed Ibrahim Mohialdeen Haider, Mohammad Rifat Hamidi, Samer Hasaballah, Ahmed I Heidari, Golnaz Hosseini, Mohammad-Salar Hosseini, Mostafa Hostiuc, Mihaela Househ, Mowafa Huang, Junjie Hugo, Fernando N Hussein, Nawfal R Islam, Jessica Y Islam, Sheikh Mohammed Shariful Jacob, Louis Jonas, Jost B Kahrizi, Danial Kamath, Ashwin Karch, André Kavetskyy, Taras Khader, Yousef Saleh Kumar, Nithin La Vecchia, Carlo Lami, Faris Hasan Leigh, James Menezes, Ritesh G Mengesha, Endalkachew Worku Michalek, Irmina Maria Miller, Ted R Mohammed, Shafiu Mokdad, Ali H Nagarajan, Ahamarshan Jayaraman Narasimha Swamy, Sreenivas Nzoputam, Chimezie Igwegbe Omonisi, Abidemi E. Emmanuel Onwujekwe, Obinna E Panagiotakos, Demosthenes Pirouzpanah, Saeed Postma, Maarten J Preotescu, Liliana Ranabhat, Kamal Rao, Sowmya J Rawassizadeh, Reza S, Manjula Salem, Marwa Rashad Sanabria, Juan Sarveazad, Arash Sekerija, Mario Sheikhbahaei, Sara Sofi-Mahmudi, Ahmad Sufiyan, Mu'awiyyah Babale Traini, Eugenio Ullah, Saif Valadan Tahbaz, Sahel Vu, Giang Thu Ward, Paul Yaya, Sanni Yu, Chuanhua Zhou, Linghui Zimmermann, Ivan R |
| description | IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world. |
| doi_str_mv | 10.1001/jamaoncol.2021.6987 |
| format | Article |
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Mequanint ; Bezabih, Yihienew Mequanint ; Bhardwaj, Nikha ; Bhattacharyya, Krittika ; Bjørge, Tone ; Catalá-López, Ferrán ; Cernigliaro, Achille ; Chaturvedi, Pankaj ; Chung, Michael T ; Costa, Vera Marisa ; das Neves, José ; Dhimal, Meghnath ; Eftekharzadeh, Sahar ; Ezzikouri, Sayeh ; Ferro Desideri, Lorenzo ; Foroutan, Masoud ; Fukumoto, Takeshi ; Gaal, Peter Andras ; Gallus, Silvano ; Glasbey, James C ; Goleij, Pouya ; Goudarzi, Houman ; Gubari, Mohammed Ibrahim Mohialdeen ; Haider, Mohammad Rifat ; Hamidi, Samer ; Hasaballah, Ahmed I ; Heidari, Golnaz ; Hosseini, Mohammad-Salar ; Hosseini, Mostafa ; Hostiuc, Mihaela ; Househ, Mowafa ; Huang, Junjie ; Hugo, Fernando N ; Hussein, Nawfal R ; Islam, Jessica Y ; Islam, Sheikh Mohammed Shariful ; Jacob, Louis ; Jonas, Jost B ; Kahrizi, Danial ; Kamath, Ashwin ; Karch, André ; Kavetskyy, Taras ; Khader, Yousef Saleh ; Kumar, Nithin ; La Vecchia, Carlo ; Lami, Faris Hasan ; Leigh, James ; Menezes, Ritesh G ; Mengesha, Endalkachew Worku ; Michalek, Irmina Maria ; Miller, Ted R ; Mohammed, Shafiu ; Mokdad, Ali H ; Nagarajan, Ahamarshan Jayaraman ; Narasimha Swamy, Sreenivas ; Nzoputam, Chimezie Igwegbe ; Omonisi, Abidemi E. Emmanuel ; Onwujekwe, Obinna E ; Panagiotakos, Demosthenes ; Pirouzpanah, Saeed ; Postma, Maarten J ; Preotescu, Liliana ; Ranabhat, Kamal ; Rao, Sowmya J ; Rawassizadeh, Reza ; S, Manjula ; Salem, Marwa Rashad ; Sanabria, Juan ; Sarveazad, Arash ; Sekerija, Mario ; Sheikhbahaei, Sara ; Sofi-Mahmudi, Ahmad ; Sufiyan, Mu'awiyyah Babale ; Traini, Eugenio ; Ullah, Saif ; Valadan Tahbaz, Sahel ; Vu, Giang Thu ; Ward, Paul ; Yaya, Sanni ; Yu, Chuanhua ; Zhou, Linghui ; Zimmermann, Ivan R</creator><creatorcontrib>Afzal, Muhammad Sohail ; Ahmad, Tauseef ; Alahdab, Fares ; Al-Aly, Ziyad ; Ali, Saqib ; Aljunid, Syed Mohamed ; Al-Maweri, Sadeq Ali Ali ; Anbesu, Etsay Woldu ; Antwi, Maxwell Hubert ; Aqeel, Muhammad ; Arabloo, Jalal ; Arab-Zozani, Morteza ; Artaman, Al ; Ayenew, Temesgen ; Badiye, Ashish D ; Baig, Atif Amin ; Balakrishnan, Senthilkumar ; Barra, Fabio ; Bezabhe, Woldesellassie M. Mequanint ; Bezabih, Yihienew Mequanint ; Bhardwaj, Nikha ; Bhattacharyya, Krittika ; Bjørge, Tone ; Catalá-López, Ferrán ; Cernigliaro, Achille ; Chaturvedi, Pankaj ; Chung, Michael T ; Costa, Vera Marisa ; das Neves, José ; Dhimal, Meghnath ; Eftekharzadeh, Sahar ; Ezzikouri, Sayeh ; Ferro Desideri, Lorenzo ; Foroutan, Masoud ; Fukumoto, Takeshi ; Gaal, Peter Andras ; Gallus, Silvano ; Glasbey, James C ; Goleij, Pouya ; Goudarzi, Houman ; Gubari, Mohammed Ibrahim Mohialdeen ; Haider, Mohammad Rifat ; Hamidi, Samer ; Hasaballah, Ahmed I ; Heidari, Golnaz ; Hosseini, Mohammad-Salar ; Hosseini, Mostafa ; Hostiuc, Mihaela ; Househ, Mowafa ; Huang, Junjie ; Hugo, Fernando N ; Hussein, Nawfal R ; Islam, Jessica Y ; Islam, Sheikh Mohammed Shariful ; Jacob, Louis ; Jonas, Jost B ; Kahrizi, Danial ; Kamath, Ashwin ; Karch, André ; Kavetskyy, Taras ; Khader, Yousef Saleh ; Kumar, Nithin ; La Vecchia, Carlo ; Lami, Faris Hasan ; Leigh, James ; Menezes, Ritesh G ; Mengesha, Endalkachew Worku ; Michalek, Irmina Maria ; Miller, Ted R ; Mohammed, Shafiu ; Mokdad, Ali H ; Nagarajan, Ahamarshan Jayaraman ; Narasimha Swamy, Sreenivas ; Nzoputam, Chimezie Igwegbe ; Omonisi, Abidemi E. Emmanuel ; Onwujekwe, Obinna E ; Panagiotakos, Demosthenes ; Pirouzpanah, Saeed ; Postma, Maarten J ; Preotescu, Liliana ; Ranabhat, Kamal ; Rao, Sowmya J ; Rawassizadeh, Reza ; S, Manjula ; Salem, Marwa Rashad ; Sanabria, Juan ; Sarveazad, Arash ; Sekerija, Mario ; Sheikhbahaei, Sara ; Sofi-Mahmudi, Ahmad ; Sufiyan, Mu'awiyyah Babale ; Traini, Eugenio ; Ullah, Saif ; Valadan Tahbaz, Sahel ; Vu, Giang Thu ; Ward, Paul ; Yaya, Sanni ; Yu, Chuanhua ; Zhou, Linghui ; Zimmermann, Ivan R ; Global Burden of Disease 2019 Cancer Collaboration</creatorcontrib><description>IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.</description><identifier>ISSN: 2374-2437</identifier><identifier>EISSN: 2374-2445</identifier><identifier>DOI: 10.1001/jamaoncol.2021.6987</identifier><identifier>PMID: 34967848</identifier><language>eng</language><publisher>United States: American Medical Association</publisher><subject>195 countries ; Cancer and Oncology ; Cancer och onkologi ; challenges ; Comments ; covid-19 ; Disability-Adjusted Life Years ; Global Burden of Disease ; Global Health ; health-care ; Humans ; Incidence ; Neoplasms - epidemiology ; Oncology ; Online First ; Original Investigation ; Prevalence ; progress ; Quality-Adjusted Life Years ; Risk Factors ; statistics ; support ; surveillance ; territories ; worldwide</subject><ispartof>JAMA oncology, 2022-03, Vol.8 (3), p.420-444</ispartof><rights>Copyright 2021 Global Burden of Disease 2019 Cancer Collaboration. .</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a405t-862fd1a2c7baf0248a9b92b1b5d46ee378df6aa748b32dc1550256a437f72c993</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,551,777,882</link.rule.ids><linktorsrc>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:148641704$$EView_record_in_Swedish_Publication_Index_(SWEPUB)$$FView_record_in_$$GSwedish_Publication_Index_(SWEPUB)$$Hfree_for_read</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/34967848$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://gup.ub.gu.se/publication/313350$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:148641704$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Afzal, Muhammad Sohail</creatorcontrib><creatorcontrib>Ahmad, Tauseef</creatorcontrib><creatorcontrib>Alahdab, Fares</creatorcontrib><creatorcontrib>Al-Aly, Ziyad</creatorcontrib><creatorcontrib>Ali, Saqib</creatorcontrib><creatorcontrib>Aljunid, Syed Mohamed</creatorcontrib><creatorcontrib>Al-Maweri, Sadeq Ali Ali</creatorcontrib><creatorcontrib>Anbesu, Etsay Woldu</creatorcontrib><creatorcontrib>Antwi, Maxwell Hubert</creatorcontrib><creatorcontrib>Aqeel, Muhammad</creatorcontrib><creatorcontrib>Arabloo, Jalal</creatorcontrib><creatorcontrib>Arab-Zozani, Morteza</creatorcontrib><creatorcontrib>Artaman, Al</creatorcontrib><creatorcontrib>Ayenew, Temesgen</creatorcontrib><creatorcontrib>Badiye, Ashish D</creatorcontrib><creatorcontrib>Baig, Atif Amin</creatorcontrib><creatorcontrib>Balakrishnan, Senthilkumar</creatorcontrib><creatorcontrib>Barra, Fabio</creatorcontrib><creatorcontrib>Bezabhe, Woldesellassie M. Mequanint</creatorcontrib><creatorcontrib>Bezabih, Yihienew Mequanint</creatorcontrib><creatorcontrib>Bhardwaj, Nikha</creatorcontrib><creatorcontrib>Bhattacharyya, Krittika</creatorcontrib><creatorcontrib>Bjørge, Tone</creatorcontrib><creatorcontrib>Catalá-López, Ferrán</creatorcontrib><creatorcontrib>Cernigliaro, Achille</creatorcontrib><creatorcontrib>Chaturvedi, Pankaj</creatorcontrib><creatorcontrib>Chung, Michael T</creatorcontrib><creatorcontrib>Costa, Vera Marisa</creatorcontrib><creatorcontrib>das Neves, José</creatorcontrib><creatorcontrib>Dhimal, Meghnath</creatorcontrib><creatorcontrib>Eftekharzadeh, Sahar</creatorcontrib><creatorcontrib>Ezzikouri, Sayeh</creatorcontrib><creatorcontrib>Ferro Desideri, Lorenzo</creatorcontrib><creatorcontrib>Foroutan, Masoud</creatorcontrib><creatorcontrib>Fukumoto, Takeshi</creatorcontrib><creatorcontrib>Gaal, Peter Andras</creatorcontrib><creatorcontrib>Gallus, Silvano</creatorcontrib><creatorcontrib>Glasbey, James C</creatorcontrib><creatorcontrib>Goleij, Pouya</creatorcontrib><creatorcontrib>Goudarzi, Houman</creatorcontrib><creatorcontrib>Gubari, Mohammed Ibrahim Mohialdeen</creatorcontrib><creatorcontrib>Haider, Mohammad Rifat</creatorcontrib><creatorcontrib>Hamidi, Samer</creatorcontrib><creatorcontrib>Hasaballah, Ahmed I</creatorcontrib><creatorcontrib>Heidari, Golnaz</creatorcontrib><creatorcontrib>Hosseini, Mohammad-Salar</creatorcontrib><creatorcontrib>Hosseini, Mostafa</creatorcontrib><creatorcontrib>Hostiuc, Mihaela</creatorcontrib><creatorcontrib>Househ, Mowafa</creatorcontrib><creatorcontrib>Huang, Junjie</creatorcontrib><creatorcontrib>Hugo, Fernando N</creatorcontrib><creatorcontrib>Hussein, Nawfal R</creatorcontrib><creatorcontrib>Islam, Jessica Y</creatorcontrib><creatorcontrib>Islam, Sheikh Mohammed Shariful</creatorcontrib><creatorcontrib>Jacob, Louis</creatorcontrib><creatorcontrib>Jonas, Jost B</creatorcontrib><creatorcontrib>Kahrizi, Danial</creatorcontrib><creatorcontrib>Kamath, Ashwin</creatorcontrib><creatorcontrib>Karch, André</creatorcontrib><creatorcontrib>Kavetskyy, Taras</creatorcontrib><creatorcontrib>Khader, Yousef Saleh</creatorcontrib><creatorcontrib>Kumar, Nithin</creatorcontrib><creatorcontrib>La Vecchia, Carlo</creatorcontrib><creatorcontrib>Lami, Faris Hasan</creatorcontrib><creatorcontrib>Leigh, James</creatorcontrib><creatorcontrib>Menezes, Ritesh G</creatorcontrib><creatorcontrib>Mengesha, Endalkachew Worku</creatorcontrib><creatorcontrib>Michalek, Irmina Maria</creatorcontrib><creatorcontrib>Miller, Ted R</creatorcontrib><creatorcontrib>Mohammed, Shafiu</creatorcontrib><creatorcontrib>Mokdad, Ali H</creatorcontrib><creatorcontrib>Nagarajan, Ahamarshan Jayaraman</creatorcontrib><creatorcontrib>Narasimha Swamy, Sreenivas</creatorcontrib><creatorcontrib>Nzoputam, Chimezie Igwegbe</creatorcontrib><creatorcontrib>Omonisi, Abidemi E. Emmanuel</creatorcontrib><creatorcontrib>Onwujekwe, Obinna E</creatorcontrib><creatorcontrib>Panagiotakos, Demosthenes</creatorcontrib><creatorcontrib>Pirouzpanah, Saeed</creatorcontrib><creatorcontrib>Postma, Maarten J</creatorcontrib><creatorcontrib>Preotescu, Liliana</creatorcontrib><creatorcontrib>Ranabhat, Kamal</creatorcontrib><creatorcontrib>Rao, Sowmya J</creatorcontrib><creatorcontrib>Rawassizadeh, Reza</creatorcontrib><creatorcontrib>S, Manjula</creatorcontrib><creatorcontrib>Salem, Marwa Rashad</creatorcontrib><creatorcontrib>Sanabria, Juan</creatorcontrib><creatorcontrib>Sarveazad, Arash</creatorcontrib><creatorcontrib>Sekerija, Mario</creatorcontrib><creatorcontrib>Sheikhbahaei, Sara</creatorcontrib><creatorcontrib>Sofi-Mahmudi, Ahmad</creatorcontrib><creatorcontrib>Sufiyan, Mu'awiyyah Babale</creatorcontrib><creatorcontrib>Traini, Eugenio</creatorcontrib><creatorcontrib>Ullah, Saif</creatorcontrib><creatorcontrib>Valadan Tahbaz, Sahel</creatorcontrib><creatorcontrib>Vu, Giang Thu</creatorcontrib><creatorcontrib>Ward, Paul</creatorcontrib><creatorcontrib>Yaya, Sanni</creatorcontrib><creatorcontrib>Yu, Chuanhua</creatorcontrib><creatorcontrib>Zhou, Linghui</creatorcontrib><creatorcontrib>Zimmermann, Ivan R</creatorcontrib><creatorcontrib>Global Burden of Disease 2019 Cancer Collaboration</creatorcontrib><title>Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019</title><title>JAMA oncology</title><addtitle>JAMA Oncol</addtitle><description>IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.</description><subject>195 countries</subject><subject>Cancer and Oncology</subject><subject>Cancer och onkologi</subject><subject>challenges</subject><subject>Comments</subject><subject>covid-19</subject><subject>Disability-Adjusted Life Years</subject><subject>Global Burden of Disease</subject><subject>Global Health</subject><subject>health-care</subject><subject>Humans</subject><subject>Incidence</subject><subject>Neoplasms - epidemiology</subject><subject>Oncology</subject><subject>Online First</subject><subject>Original Investigation</subject><subject>Prevalence</subject><subject>progress</subject><subject>Quality-Adjusted Life Years</subject><subject>Risk Factors</subject><subject>statistics</subject><subject>support</subject><subject>surveillance</subject><subject>territories</subject><subject>worldwide</subject><issn>2374-2437</issn><issn>2374-2445</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>D8T</sourceid><recordid>eNp9ksFu1DAQhiMEolXpC4CE_ADNYjtOHHNAWha6VAriUBDiZE0SZ9dLEq9spyivytPgNNuovXCa8cz_zYysP4reELwiGJN3B-jA9JVpVxRTsspEzp9F5zThLKaMpc-XPOFn0aVzBxwoxnHG6MvoLGEi4znLz6O_G-grZdFNX-lahfQKfTXWQ6v9eIV-KbAOmQYVulGoMM4_1Ap9p2r0U_s9-qQdlHoGoK8fveN1fRicD8J7fiYbYxEV6LR3a81wdOjamg5RTDDyZoriPVqj2zGwHXhdoXUP7ej0TPu9QtvWlNCij4MNV08Xhq0KnEK3fqjH-xGvohcNtE5dnuJF9OP68_fNl7j4tr3ZrIsYGE59nGe0qQnQipfQYMpyEKWgJSnTmmVKJTyvmwyAs7xMaF2RNMU0zSB8bMNpJURyEcXzXPdHHYdSHq3uwI7SgJan0u-QKcnSLBX5f_W74ShDaTdM-oQkSYqD_sOsD-JO1ZXqvYX2Cfa00-u93Jk7mXMiKM_CgGQeUFnjnFXNwhIsJzfJxU1ycpOc3BSot4_XLsyDd4Lg9SwI8NKlPKDh6H9xtNKr</recordid><startdate>20220301</startdate><enddate>20220301</enddate><creator>Afzal, Muhammad Sohail</creator><creator>Ahmad, Tauseef</creator><creator>Alahdab, Fares</creator><creator>Al-Aly, Ziyad</creator><creator>Ali, Saqib</creator><creator>Aljunid, Syed Mohamed</creator><creator>Al-Maweri, Sadeq Ali Ali</creator><creator>Anbesu, Etsay Woldu</creator><creator>Antwi, Maxwell Hubert</creator><creator>Aqeel, Muhammad</creator><creator>Arabloo, Jalal</creator><creator>Arab-Zozani, Morteza</creator><creator>Artaman, Al</creator><creator>Ayenew, Temesgen</creator><creator>Badiye, Ashish D</creator><creator>Baig, Atif Amin</creator><creator>Balakrishnan, Senthilkumar</creator><creator>Barra, Fabio</creator><creator>Bezabhe, Woldesellassie M. 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Mequanint ; Bezabih, Yihienew Mequanint ; Bhardwaj, Nikha ; Bhattacharyya, Krittika ; Bjørge, Tone ; Catalá-López, Ferrán ; Cernigliaro, Achille ; Chaturvedi, Pankaj ; Chung, Michael T ; Costa, Vera Marisa ; das Neves, José ; Dhimal, Meghnath ; Eftekharzadeh, Sahar ; Ezzikouri, Sayeh ; Ferro Desideri, Lorenzo ; Foroutan, Masoud ; Fukumoto, Takeshi ; Gaal, Peter Andras ; Gallus, Silvano ; Glasbey, James C ; Goleij, Pouya ; Goudarzi, Houman ; Gubari, Mohammed Ibrahim Mohialdeen ; Haider, Mohammad Rifat ; Hamidi, Samer ; Hasaballah, Ahmed I ; Heidari, Golnaz ; Hosseini, Mohammad-Salar ; Hosseini, Mostafa ; Hostiuc, Mihaela ; Househ, Mowafa ; Huang, Junjie ; Hugo, Fernando N ; Hussein, Nawfal R ; Islam, Jessica Y ; Islam, Sheikh Mohammed Shariful ; Jacob, Louis ; Jonas, Jost B ; Kahrizi, Danial ; Kamath, Ashwin ; Karch, André ; Kavetskyy, Taras ; Khader, Yousef Saleh ; Kumar, Nithin ; La Vecchia, Carlo ; Lami, Faris Hasan ; Leigh, James ; Menezes, Ritesh G ; Mengesha, Endalkachew Worku ; Michalek, Irmina Maria ; Miller, Ted R ; Mohammed, Shafiu ; Mokdad, Ali H ; Nagarajan, Ahamarshan Jayaraman ; Narasimha Swamy, Sreenivas ; Nzoputam, Chimezie Igwegbe ; Omonisi, Abidemi E. Emmanuel ; Onwujekwe, Obinna E ; Panagiotakos, Demosthenes ; Pirouzpanah, Saeed ; Postma, Maarten J ; Preotescu, Liliana ; Ranabhat, Kamal ; Rao, Sowmya J ; Rawassizadeh, Reza ; S, Manjula ; Salem, Marwa Rashad ; Sanabria, Juan ; Sarveazad, Arash ; Sekerija, Mario ; Sheikhbahaei, Sara ; Sofi-Mahmudi, Ahmad ; Sufiyan, Mu'awiyyah Babale ; Traini, Eugenio ; Ullah, Saif ; Valadan Tahbaz, Sahel ; Vu, Giang Thu ; Ward, Paul ; Yaya, Sanni ; Yu, Chuanhua ; Zhou, Linghui ; Zimmermann, Ivan R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a405t-862fd1a2c7baf0248a9b92b1b5d46ee378df6aa748b32dc1550256a437f72c993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>195 countries</topic><topic>Cancer and Oncology</topic><topic>Cancer och onkologi</topic><topic>challenges</topic><topic>Comments</topic><topic>covid-19</topic><topic>Disability-Adjusted Life Years</topic><topic>Global Burden of Disease</topic><topic>Global Health</topic><topic>health-care</topic><topic>Humans</topic><topic>Incidence</topic><topic>Neoplasms - epidemiology</topic><topic>Oncology</topic><topic>Online First</topic><topic>Original Investigation</topic><topic>Prevalence</topic><topic>progress</topic><topic>Quality-Adjusted Life Years</topic><topic>Risk Factors</topic><topic>statistics</topic><topic>support</topic><topic>surveillance</topic><topic>territories</topic><topic>worldwide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Afzal, Muhammad Sohail</creatorcontrib><creatorcontrib>Ahmad, Tauseef</creatorcontrib><creatorcontrib>Alahdab, Fares</creatorcontrib><creatorcontrib>Al-Aly, Ziyad</creatorcontrib><creatorcontrib>Ali, Saqib</creatorcontrib><creatorcontrib>Aljunid, Syed Mohamed</creatorcontrib><creatorcontrib>Al-Maweri, Sadeq Ali Ali</creatorcontrib><creatorcontrib>Anbesu, Etsay Woldu</creatorcontrib><creatorcontrib>Antwi, Maxwell Hubert</creatorcontrib><creatorcontrib>Aqeel, Muhammad</creatorcontrib><creatorcontrib>Arabloo, Jalal</creatorcontrib><creatorcontrib>Arab-Zozani, Morteza</creatorcontrib><creatorcontrib>Artaman, Al</creatorcontrib><creatorcontrib>Ayenew, Temesgen</creatorcontrib><creatorcontrib>Badiye, Ashish D</creatorcontrib><creatorcontrib>Baig, Atif Amin</creatorcontrib><creatorcontrib>Balakrishnan, Senthilkumar</creatorcontrib><creatorcontrib>Barra, Fabio</creatorcontrib><creatorcontrib>Bezabhe, Woldesellassie M. 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Emmanuel</creatorcontrib><creatorcontrib>Onwujekwe, Obinna E</creatorcontrib><creatorcontrib>Panagiotakos, Demosthenes</creatorcontrib><creatorcontrib>Pirouzpanah, Saeed</creatorcontrib><creatorcontrib>Postma, Maarten J</creatorcontrib><creatorcontrib>Preotescu, Liliana</creatorcontrib><creatorcontrib>Ranabhat, Kamal</creatorcontrib><creatorcontrib>Rao, Sowmya J</creatorcontrib><creatorcontrib>Rawassizadeh, Reza</creatorcontrib><creatorcontrib>S, Manjula</creatorcontrib><creatorcontrib>Salem, Marwa Rashad</creatorcontrib><creatorcontrib>Sanabria, Juan</creatorcontrib><creatorcontrib>Sarveazad, Arash</creatorcontrib><creatorcontrib>Sekerija, Mario</creatorcontrib><creatorcontrib>Sheikhbahaei, Sara</creatorcontrib><creatorcontrib>Sofi-Mahmudi, Ahmad</creatorcontrib><creatorcontrib>Sufiyan, Mu'awiyyah Babale</creatorcontrib><creatorcontrib>Traini, Eugenio</creatorcontrib><creatorcontrib>Ullah, Saif</creatorcontrib><creatorcontrib>Valadan Tahbaz, Sahel</creatorcontrib><creatorcontrib>Vu, Giang Thu</creatorcontrib><creatorcontrib>Ward, Paul</creatorcontrib><creatorcontrib>Yaya, Sanni</creatorcontrib><creatorcontrib>Yu, Chuanhua</creatorcontrib><creatorcontrib>Zhou, Linghui</creatorcontrib><creatorcontrib>Zimmermann, Ivan R</creatorcontrib><creatorcontrib>Global Burden of Disease 2019 Cancer Collaboration</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Göteborgs universitet</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>JAMA oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Afzal, Muhammad Sohail</au><au>Ahmad, Tauseef</au><au>Alahdab, Fares</au><au>Al-Aly, Ziyad</au><au>Ali, Saqib</au><au>Aljunid, Syed Mohamed</au><au>Al-Maweri, Sadeq Ali Ali</au><au>Anbesu, Etsay Woldu</au><au>Antwi, Maxwell Hubert</au><au>Aqeel, Muhammad</au><au>Arabloo, Jalal</au><au>Arab-Zozani, Morteza</au><au>Artaman, Al</au><au>Ayenew, Temesgen</au><au>Badiye, Ashish D</au><au>Baig, Atif Amin</au><au>Balakrishnan, Senthilkumar</au><au>Barra, Fabio</au><au>Bezabhe, Woldesellassie M. Mequanint</au><au>Bezabih, Yihienew Mequanint</au><au>Bhardwaj, Nikha</au><au>Bhattacharyya, Krittika</au><au>Bjørge, Tone</au><au>Catalá-López, Ferrán</au><au>Cernigliaro, Achille</au><au>Chaturvedi, Pankaj</au><au>Chung, Michael T</au><au>Costa, Vera Marisa</au><au>das Neves, José</au><au>Dhimal, Meghnath</au><au>Eftekharzadeh, Sahar</au><au>Ezzikouri, Sayeh</au><au>Ferro Desideri, Lorenzo</au><au>Foroutan, Masoud</au><au>Fukumoto, Takeshi</au><au>Gaal, Peter Andras</au><au>Gallus, Silvano</au><au>Glasbey, James C</au><au>Goleij, Pouya</au><au>Goudarzi, Houman</au><au>Gubari, Mohammed Ibrahim Mohialdeen</au><au>Haider, Mohammad Rifat</au><au>Hamidi, Samer</au><au>Hasaballah, Ahmed I</au><au>Heidari, Golnaz</au><au>Hosseini, Mohammad-Salar</au><au>Hosseini, Mostafa</au><au>Hostiuc, Mihaela</au><au>Househ, Mowafa</au><au>Huang, Junjie</au><au>Hugo, Fernando N</au><au>Hussein, Nawfal R</au><au>Islam, Jessica Y</au><au>Islam, Sheikh Mohammed Shariful</au><au>Jacob, Louis</au><au>Jonas, Jost B</au><au>Kahrizi, Danial</au><au>Kamath, Ashwin</au><au>Karch, André</au><au>Kavetskyy, Taras</au><au>Khader, Yousef Saleh</au><au>Kumar, Nithin</au><au>La Vecchia, Carlo</au><au>Lami, Faris Hasan</au><au>Leigh, James</au><au>Menezes, Ritesh G</au><au>Mengesha, Endalkachew Worku</au><au>Michalek, Irmina Maria</au><au>Miller, Ted R</au><au>Mohammed, Shafiu</au><au>Mokdad, Ali H</au><au>Nagarajan, Ahamarshan Jayaraman</au><au>Narasimha Swamy, Sreenivas</au><au>Nzoputam, Chimezie Igwegbe</au><au>Omonisi, Abidemi E. Emmanuel</au><au>Onwujekwe, Obinna E</au><au>Panagiotakos, Demosthenes</au><au>Pirouzpanah, Saeed</au><au>Postma, Maarten J</au><au>Preotescu, Liliana</au><au>Ranabhat, Kamal</au><au>Rao, Sowmya J</au><au>Rawassizadeh, Reza</au><au>S, Manjula</au><au>Salem, Marwa Rashad</au><au>Sanabria, Juan</au><au>Sarveazad, Arash</au><au>Sekerija, Mario</au><au>Sheikhbahaei, Sara</au><au>Sofi-Mahmudi, Ahmad</au><au>Sufiyan, Mu'awiyyah Babale</au><au>Traini, Eugenio</au><au>Ullah, Saif</au><au>Valadan Tahbaz, Sahel</au><au>Vu, Giang Thu</au><au>Ward, Paul</au><au>Yaya, Sanni</au><au>Yu, Chuanhua</au><au>Zhou, Linghui</au><au>Zimmermann, Ivan R</au><aucorp>Global Burden of Disease 2019 Cancer Collaboration</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019</atitle><jtitle>JAMA oncology</jtitle><addtitle>JAMA Oncol</addtitle><date>2022-03-01</date><risdate>2022</risdate><volume>8</volume><issue>3</issue><spage>420</spage><epage>444</epage><pages>420-444</pages><issn>2374-2437</issn><eissn>2374-2445</eissn><abstract>IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.</abstract><cop>United States</cop><pub>American Medical Association</pub><pmid>34967848</pmid><doi>10.1001/jamaoncol.2021.6987</doi><tpages>25</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 2374-2437 |
| ispartof | JAMA oncology, 2022-03, Vol.8 (3), p.420-444 |
| issn | 2374-2437 2374-2445 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_456598 |
| source | SWEPUB Freely available online |
| subjects | 195 countries Cancer and Oncology Cancer och onkologi challenges Comments covid-19 Disability-Adjusted Life Years Global Burden of Disease Global Health health-care Humans Incidence Neoplasms - epidemiology Oncology Online First Original Investigation Prevalence progress Quality-Adjusted Life Years Risk Factors statistics support surveillance territories worldwide |
| title | Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019 |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-19T18%3A01%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-pubmed_D8T&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Cancer%20Incidence,%20Mortality,%20Years%20of%20Life%20Lost,%20Years%20Lived%20With%20Disability,%20and%20Disability-Adjusted%20Life%20Years%20for%2029%20Cancer%20Groups%20From%202010%20to%202019:%20A%20Systematic%20Analysis%20for%20the%20Global%20Burden%20of%20Disease%20Study%202019&rft.jtitle=JAMA%20oncology&rft.au=Afzal,%20Muhammad%20Sohail&rft.aucorp=Global%20Burden%20of%20Disease%202019%20Cancer%20Collaboration&rft.date=2022-03-01&rft.volume=8&rft.issue=3&rft.spage=420&rft.epage=444&rft.pages=420-444&rft.issn=2374-2437&rft.eissn=2374-2445&rft_id=info:doi/10.1001/jamaoncol.2021.6987&rft_dat=%3Cpubmed_D8T%3E34967848%3C/pubmed_D8T%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/34967848&rft_ama_id=2787350&rfr_iscdi=true |