Broad anti-SARS-CoV-2 antibody immunity induced by heterologous ChAdOx1/mRNA-1273 vaccination

Heterologous prime-boost immunization strategies have the potential to augment COVID-19 vaccine efficacy. We longitudinally profiled severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S)-specific serological and memory B cell (MBC) responses in individuals who received either homolo...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Science (American Association for the Advancement of Science) 2022-03, Vol.375 (6584), p.1041-1047
Hauptverfasser:	Kaku, Chengzi I, Champney, Elizabeth R, Normark, Johan, Garcia, Marina, Johnson, Carl E, Ahlm, Clas, Christ, Wanda, Sakharkar, Mrunal, Ackerman, Margaret E, Klingström, Jonas, Forsell, Mattias N E, Walker, Laura M
Format:	Artikel
Sprache:	eng
Schlagworte:	2019-nCoV Vaccine mRNA-1273 - administration & dosage 2019-nCoV Vaccine mRNA-1273 - immunology Adult Antibodies Antibodies, Monoclonal - immunology Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Antibody Specificity ChAdOx1 nCoV-19 - administration & dosage ChAdOx1 nCoV-19 - immunology Conformation Coronaviruses COVID-19 Vaccines - immunology Epitopes Female Humans Immune response Immune system Immunity Immunization Schedule Immunization, Secondary Immunogenicity, Vaccine Immunology Male Memory B Cells - immunology Middle Aged mRNA mRNA vaccines Pandemics Protein Conformation Protein Domains SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - chemistry Spike Glycoprotein, Coronavirus - immunology Vaccines Viral diseases
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!