Measuring heritable contributions to Alzheimer’s disease: polygenic risk score analysis with twins

Abstract The heritability of Alzheimer’s disease estimated from twin studies is greater than the heritability derived from genome-based studies, for reasons that remain unclear. We apply both approaches to the same twin sample, considering both Alzheimer’s disease polygenic risk scores and heritabil...

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Veröffentlicht in:	BRAIN COMMUNICATIONS 2022, Vol.4 (1), p.fcab308-fcab308
Hauptverfasser:	Karlsson, Ida K., Escott-Price, Valentina, Gatz, Margaret, Hardy, John, Pedersen, Nancy L., Shoai, Maryam, Reynolds, Chandra A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease APOE Editor's Choice heritability Original polygenic risk scores (PRSs) twins
Online-Zugang:	Volltext
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