Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis
Introduction Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project....
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| Veröffentlicht in: | JOURNAL OF THE INTERNATIONAL AIDS SOCIETY 2022-03, Vol.25 (3), p.e25871-n/a |
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| creator | Jesson, Julie Crichton, Siobhan Quartagno, Matteo Yotebieng, Marcel Abrams, Elaine J. Chokephaibulkit, Kulkanya Le Coeur, Sophie Aké‐Assi, Marie‐Hélène Patel, Kunjal Pinto, Jorge Paul, Mary Vreeman, Rachel Davies, Mary‐Ann Ben‐Farhat, Jihane Van Dyke, Russell Judd, Ali Mofenson, Lynne Vicari, Marissa Seage, George Bekker, Linda‐Gail Essajee, Shaffiq Gibb, Diana Penazzato, Martina Collins, Intira Jeannie Wools‐Kaloustian, Kara Slogrove, Amy Powis, Kate Williams, Paige Matshaba, Mogomotsi Thahane, Lineo Nyasulu, Phoebe Lukhele, Bhekumusa Mwita, Lumumba Kekitiinwa‐Rukyalekere, Adeodata Wanless, Sebastian Goetghebuer, Tessa Thorne, Claire Warszawski, Josiane Galli, Luisa Rossum, Annemarie M.C Giaquinto, Carlo Marczynska, Magdalena Marques, Laura Prata, Filipa Ene, Luminita Okhonskaya, Lyuba Navarro, Marisa Frick, Antoinette Naver, Lars Kahlert, Christian Volokha, Alla Chappell, Elizabeth Pape, Jean William Rouzier, Vanessa Marcelin, Adias Succi, Regina Sohn, Annette H. Kariminia, Azar Edmonds, Andrew Lelo, Patricia Lyamuya, Rita Ogalo, Edith Apondi Odhiambo, Francesca Akoth Haas, Andreas D. Bolton, Carolyn Muhairwe, Josephine Tweya, Hannock Sylla, Mariam D'Almeida, Marceline Renner, Lorna Abzug, Mark J. Oleske, James Purswani, Murli Teasdale, Chloe Nuwagaba‐Biribonwoha, Harriet Goodall, Ruth Leroy, Valériane |
| description | Introduction
Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project.
Methods
Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height‐for‐age Z‐scores (HAZ, stunting if |
| doi_str_mv | 10.1002/jia2.25871 |
| format | Article |
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Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project.
Methods
Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height‐for‐age Z‐scores (HAZ, stunting if <‐2 SD, WHO growth charts). Linear mixed‐effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex‐specific models with fractional polynomials were used to model non‐linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age.
Results
A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two‐thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub‐Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia‐Pacific; 19% overall had CD4 counts <500 cells/mm3. Across adolescence, higher HAZ was observed in females and among those in high‐income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch‐up with non‐stunted, early ART‐treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm3. This decline was observed across all regions, in males and females.
Conclusions
Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood.</description><identifier>ISSN: 1758-2652</identifier><identifier>EISSN: 1758-2652</identifier><identifier>DOI: 10.1002/jia2.25871</identifier><identifier>PMID: 35255197</identifier><language>eng</language><publisher>Switzerland: John Wiley & Sons, Inc</publisher><subject>Acquired immune deficiency syndrome ; Adolescent ; Adolescent development ; Adolescents ; Adult ; AIDS ; Antiretroviral agents ; CD4 ; CD4 Lymphocyte Count ; CD4 lymphocytes ; Child ; Child, Preschool ; Cohort analysis ; Cohort Studies ; Collaboration ; Complications and side effects ; Female ; Growth ; Growth Disorders - epidemiology ; Health aspects ; HIV ; HIV infection ; HIV Infections - drug therapy ; HIV Infections - epidemiology ; Human immunodeficiency virus ; Humans ; Income ; International aspects ; Life Sciences ; Male ; Pediatric research ; Perinatal infection ; perinatally acquired ; Sexually transmitted diseases ; Statistics ; STD ; Teenagers</subject><ispartof>JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2022-03, Vol.25 (3), p.e25871-n/a</ispartof><rights>2022 The Authors. published by John Wiley & Sons Ltd on behalf of the International AIDS Society.</rights><rights>2022 The Authors. Journal of the International AIDS Society published by John Wiley & Sons Ltd on behalf of the International AIDS Society.</rights><rights>COPYRIGHT 2022 John Wiley & Sons, Inc.</rights><rights>2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Attribution</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5511-46a0f658ce432e146d696a6a970bf36c4d4665846b5426b763d8ebfa1ea7cf063</citedby><cites>FETCH-LOGICAL-c5511-46a0f658ce432e146d696a6a970bf36c4d4665846b5426b763d8ebfa1ea7cf063</cites><orcidid>0000-0001-9103-7746 ; 0000-0002-4849-181X ; 0000-0002-0140-4600 ; 0000-0001-8496-6475 ; 0000-0002-4478-4471 ; 0000-0002-9461-2520 ; 0000-0002-0209-3285 ; 0000-0003-2132-6037 ; 0000-0002-2818-9808 ; 0000-0002-7968-9394 ; 0000-0003-1053-6434 ; 0000-0002-0755-4386 ; 0000-0002-0784-3276 ; 0000-0003-0002-681X ; 0000-0003-3176-5295 ; 0000-0001-5131-3371 ; 0000-0003-3542-8616 ; 0000-0001-5485-8692 ; 0000-0001-6952-9234</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901148/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8901148/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,551,724,777,781,861,882,1412,11543,27905,27906,45555,45556,46033,46457,53772,53774</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35255197$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://ut3-toulouseinp.hal.science/hal-04552847$$DView record in HAL$$Hfree_for_read</backlink><backlink>$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:149134203$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Jesson, Julie</creatorcontrib><creatorcontrib>Crichton, Siobhan</creatorcontrib><creatorcontrib>Quartagno, Matteo</creatorcontrib><creatorcontrib>Yotebieng, Marcel</creatorcontrib><creatorcontrib>Abrams, Elaine J.</creatorcontrib><creatorcontrib>Chokephaibulkit, Kulkanya</creatorcontrib><creatorcontrib>Le Coeur, Sophie</creatorcontrib><creatorcontrib>Aké‐Assi, Marie‐Hélène</creatorcontrib><creatorcontrib>Patel, Kunjal</creatorcontrib><creatorcontrib>Pinto, Jorge</creatorcontrib><creatorcontrib>Paul, Mary</creatorcontrib><creatorcontrib>Vreeman, Rachel</creatorcontrib><creatorcontrib>Davies, Mary‐Ann</creatorcontrib><creatorcontrib>Ben‐Farhat, Jihane</creatorcontrib><creatorcontrib>Van Dyke, Russell</creatorcontrib><creatorcontrib>Judd, Ali</creatorcontrib><creatorcontrib>Mofenson, Lynne</creatorcontrib><creatorcontrib>Vicari, Marissa</creatorcontrib><creatorcontrib>Seage, George</creatorcontrib><creatorcontrib>Bekker, Linda‐Gail</creatorcontrib><creatorcontrib>Essajee, Shaffiq</creatorcontrib><creatorcontrib>Gibb, Diana</creatorcontrib><creatorcontrib>Penazzato, Martina</creatorcontrib><creatorcontrib>Collins, Intira Jeannie</creatorcontrib><creatorcontrib>Wools‐Kaloustian, Kara</creatorcontrib><creatorcontrib>Slogrove, Amy</creatorcontrib><creatorcontrib>Powis, Kate</creatorcontrib><creatorcontrib>Williams, Paige</creatorcontrib><creatorcontrib>Matshaba, Mogomotsi</creatorcontrib><creatorcontrib>Thahane, Lineo</creatorcontrib><creatorcontrib>Nyasulu, Phoebe</creatorcontrib><creatorcontrib>Lukhele, Bhekumusa</creatorcontrib><creatorcontrib>Mwita, Lumumba</creatorcontrib><creatorcontrib>Kekitiinwa‐Rukyalekere, Adeodata</creatorcontrib><creatorcontrib>Wanless, Sebastian</creatorcontrib><creatorcontrib>Goetghebuer, Tessa</creatorcontrib><creatorcontrib>Thorne, Claire</creatorcontrib><creatorcontrib>Warszawski, Josiane</creatorcontrib><creatorcontrib>Galli, Luisa</creatorcontrib><creatorcontrib>Rossum, Annemarie M.C</creatorcontrib><creatorcontrib>Giaquinto, Carlo</creatorcontrib><creatorcontrib>Marczynska, Magdalena</creatorcontrib><creatorcontrib>Marques, Laura</creatorcontrib><creatorcontrib>Prata, Filipa</creatorcontrib><creatorcontrib>Ene, Luminita</creatorcontrib><creatorcontrib>Okhonskaya, Lyuba</creatorcontrib><creatorcontrib>Navarro, Marisa</creatorcontrib><creatorcontrib>Frick, Antoinette</creatorcontrib><creatorcontrib>Naver, Lars</creatorcontrib><creatorcontrib>Kahlert, Christian</creatorcontrib><creatorcontrib>Volokha, Alla</creatorcontrib><creatorcontrib>Chappell, Elizabeth</creatorcontrib><creatorcontrib>Pape, Jean William</creatorcontrib><creatorcontrib>Rouzier, Vanessa</creatorcontrib><creatorcontrib>Marcelin, Adias</creatorcontrib><creatorcontrib>Succi, Regina</creatorcontrib><creatorcontrib>Sohn, Annette H.</creatorcontrib><creatorcontrib>Kariminia, Azar</creatorcontrib><creatorcontrib>Edmonds, Andrew</creatorcontrib><creatorcontrib>Lelo, Patricia</creatorcontrib><creatorcontrib>Lyamuya, Rita</creatorcontrib><creatorcontrib>Ogalo, Edith Apondi</creatorcontrib><creatorcontrib>Odhiambo, Francesca Akoth</creatorcontrib><creatorcontrib>Haas, Andreas D.</creatorcontrib><creatorcontrib>Bolton, Carolyn</creatorcontrib><creatorcontrib>Muhairwe, Josephine</creatorcontrib><creatorcontrib>Tweya, Hannock</creatorcontrib><creatorcontrib>Sylla, Mariam</creatorcontrib><creatorcontrib>D'Almeida, Marceline</creatorcontrib><creatorcontrib>Renner, Lorna</creatorcontrib><creatorcontrib>Abzug, Mark J.</creatorcontrib><creatorcontrib>Oleske, James</creatorcontrib><creatorcontrib>Purswani, Murli</creatorcontrib><creatorcontrib>Teasdale, Chloe</creatorcontrib><creatorcontrib>Nuwagaba‐Biribonwoha, Harriet</creatorcontrib><creatorcontrib>Goodall, Ruth</creatorcontrib><creatorcontrib>Leroy, Valériane</creatorcontrib><creatorcontrib>Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration</creatorcontrib><creatorcontrib>The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration</creatorcontrib><title>Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis</title><title>JOURNAL OF THE INTERNATIONAL AIDS SOCIETY</title><addtitle>J Int AIDS Soc</addtitle><description>Introduction
Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project.
Methods
Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height‐for‐age Z‐scores (HAZ, stunting if <‐2 SD, WHO growth charts). Linear mixed‐effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex‐specific models with fractional polynomials were used to model non‐linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age.
Results
A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two‐thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub‐Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia‐Pacific; 19% overall had CD4 counts <500 cells/mm3. Across adolescence, higher HAZ was observed in females and among those in high‐income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch‐up with non‐stunted, early ART‐treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm3. This decline was observed across all regions, in males and females.
Conclusions
Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood.</description><subject>Acquired immune deficiency syndrome</subject><subject>Adolescent</subject><subject>Adolescent development</subject><subject>Adolescents</subject><subject>Adult</subject><subject>AIDS</subject><subject>Antiretroviral agents</subject><subject>CD4</subject><subject>CD4 Lymphocyte Count</subject><subject>CD4 lymphocytes</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Collaboration</subject><subject>Complications and side effects</subject><subject>Female</subject><subject>Growth</subject><subject>Growth Disorders - epidemiology</subject><subject>Health aspects</subject><subject>HIV</subject><subject>HIV infection</subject><subject>HIV Infections - drug therapy</subject><subject>HIV Infections - epidemiology</subject><subject>Human immunodeficiency virus</subject><subject>Humans</subject><subject>Income</subject><subject>International aspects</subject><subject>Life Sciences</subject><subject>Male</subject><subject>Pediatric research</subject><subject>Perinatal infection</subject><subject>perinatally acquired</subject><subject>Sexually transmitted 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and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis</title><author>Jesson, Julie ; Crichton, Siobhan ; Quartagno, Matteo ; Yotebieng, Marcel ; Abrams, Elaine J. ; Chokephaibulkit, Kulkanya ; Le Coeur, Sophie ; Aké‐Assi, Marie‐Hélène ; Patel, Kunjal ; Pinto, Jorge ; Paul, Mary ; Vreeman, Rachel ; Davies, Mary‐Ann ; Ben‐Farhat, Jihane ; Van Dyke, Russell ; Judd, Ali ; Mofenson, Lynne ; Vicari, Marissa ; Seage, George ; Bekker, Linda‐Gail ; Essajee, Shaffiq ; Gibb, Diana ; Penazzato, Martina ; Collins, Intira Jeannie ; Wools‐Kaloustian, Kara ; Slogrove, Amy ; Powis, Kate ; Williams, Paige ; Matshaba, Mogomotsi ; Thahane, Lineo ; Nyasulu, Phoebe ; Lukhele, Bhekumusa ; Mwita, Lumumba ; Kekitiinwa‐Rukyalekere, Adeodata ; Wanless, Sebastian ; Goetghebuer, Tessa ; Thorne, Claire ; Warszawski, Josiane ; Galli, Luisa ; Rossum, Annemarie M.C ; Giaquinto, Carlo ; Marczynska, Magdalena ; Marques, Laura ; Prata, Filipa ; Ene, Luminita ; Okhonskaya, Lyuba ; Navarro, Marisa ; Frick, Antoinette ; Naver, Lars ; Kahlert, Christian ; Volokha, Alla ; Chappell, Elizabeth ; Pape, Jean William ; Rouzier, Vanessa ; Marcelin, Adias ; Succi, Regina ; Sohn, Annette H. ; Kariminia, Azar ; Edmonds, Andrew ; Lelo, Patricia ; Lyamuya, Rita ; Ogalo, Edith Apondi ; Odhiambo, Francesca Akoth ; Haas, Andreas D. ; Bolton, Carolyn ; Muhairwe, Josephine ; Tweya, Hannock ; Sylla, Mariam ; D'Almeida, Marceline ; Renner, Lorna ; Abzug, Mark J. ; Oleske, James ; Purswani, Murli ; Teasdale, Chloe ; Nuwagaba‐Biribonwoha, Harriet ; Goodall, Ruth ; Leroy, Valériane</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5511-46a0f658ce432e146d696a6a970bf36c4d4665846b5426b763d8ebfa1ea7cf063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acquired immune deficiency syndrome</topic><topic>Adolescent</topic><topic>Adolescent development</topic><topic>Adolescents</topic><topic>Adult</topic><topic>AIDS</topic><topic>Antiretroviral agents</topic><topic>CD4</topic><topic>CD4 Lymphocyte Count</topic><topic>CD4 lymphocytes</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Collaboration</topic><topic>Complications and side effects</topic><topic>Female</topic><topic>Growth</topic><topic>Growth Disorders - epidemiology</topic><topic>Health aspects</topic><topic>HIV</topic><topic>HIV infection</topic><topic>HIV Infections - drug therapy</topic><topic>HIV Infections - epidemiology</topic><topic>Human immunodeficiency virus</topic><topic>Humans</topic><topic>Income</topic><topic>International aspects</topic><topic>Life Sciences</topic><topic>Male</topic><topic>Pediatric research</topic><topic>Perinatal infection</topic><topic>perinatally acquired</topic><topic>Sexually transmitted diseases</topic><topic>Statistics</topic><topic>STD</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jesson, Julie</creatorcontrib><creatorcontrib>Crichton, Siobhan</creatorcontrib><creatorcontrib>Quartagno, Matteo</creatorcontrib><creatorcontrib>Yotebieng, Marcel</creatorcontrib><creatorcontrib>Abrams, Elaine J.</creatorcontrib><creatorcontrib>Chokephaibulkit, Kulkanya</creatorcontrib><creatorcontrib>Le Coeur, Sophie</creatorcontrib><creatorcontrib>Aké‐Assi, Marie‐Hélène</creatorcontrib><creatorcontrib>Patel, Kunjal</creatorcontrib><creatorcontrib>Pinto, Jorge</creatorcontrib><creatorcontrib>Paul, Mary</creatorcontrib><creatorcontrib>Vreeman, Rachel</creatorcontrib><creatorcontrib>Davies, Mary‐Ann</creatorcontrib><creatorcontrib>Ben‐Farhat, Jihane</creatorcontrib><creatorcontrib>Van Dyke, Russell</creatorcontrib><creatorcontrib>Judd, Ali</creatorcontrib><creatorcontrib>Mofenson, Lynne</creatorcontrib><creatorcontrib>Vicari, Marissa</creatorcontrib><creatorcontrib>Seage, George</creatorcontrib><creatorcontrib>Bekker, Linda‐Gail</creatorcontrib><creatorcontrib>Essajee, Shaffiq</creatorcontrib><creatorcontrib>Gibb, Diana</creatorcontrib><creatorcontrib>Penazzato, Martina</creatorcontrib><creatorcontrib>Collins, Intira Jeannie</creatorcontrib><creatorcontrib>Wools‐Kaloustian, Kara</creatorcontrib><creatorcontrib>Slogrove, Amy</creatorcontrib><creatorcontrib>Powis, Kate</creatorcontrib><creatorcontrib>Williams, Paige</creatorcontrib><creatorcontrib>Matshaba, Mogomotsi</creatorcontrib><creatorcontrib>Thahane, Lineo</creatorcontrib><creatorcontrib>Nyasulu, Phoebe</creatorcontrib><creatorcontrib>Lukhele, Bhekumusa</creatorcontrib><creatorcontrib>Mwita, Lumumba</creatorcontrib><creatorcontrib>Kekitiinwa‐Rukyalekere, Adeodata</creatorcontrib><creatorcontrib>Wanless, Sebastian</creatorcontrib><creatorcontrib>Goetghebuer, Tessa</creatorcontrib><creatorcontrib>Thorne, Claire</creatorcontrib><creatorcontrib>Warszawski, Josiane</creatorcontrib><creatorcontrib>Galli, Luisa</creatorcontrib><creatorcontrib>Rossum, Annemarie M.C</creatorcontrib><creatorcontrib>Giaquinto, Carlo</creatorcontrib><creatorcontrib>Marczynska, Magdalena</creatorcontrib><creatorcontrib>Marques, Laura</creatorcontrib><creatorcontrib>Prata, Filipa</creatorcontrib><creatorcontrib>Ene, Luminita</creatorcontrib><creatorcontrib>Okhonskaya, Lyuba</creatorcontrib><creatorcontrib>Navarro, Marisa</creatorcontrib><creatorcontrib>Frick, Antoinette</creatorcontrib><creatorcontrib>Naver, Lars</creatorcontrib><creatorcontrib>Kahlert, Christian</creatorcontrib><creatorcontrib>Volokha, Alla</creatorcontrib><creatorcontrib>Chappell, Elizabeth</creatorcontrib><creatorcontrib>Pape, Jean William</creatorcontrib><creatorcontrib>Rouzier, Vanessa</creatorcontrib><creatorcontrib>Marcelin, Adias</creatorcontrib><creatorcontrib>Succi, Regina</creatorcontrib><creatorcontrib>Sohn, Annette H.</creatorcontrib><creatorcontrib>Kariminia, Azar</creatorcontrib><creatorcontrib>Edmonds, Andrew</creatorcontrib><creatorcontrib>Lelo, Patricia</creatorcontrib><creatorcontrib>Lyamuya, Rita</creatorcontrib><creatorcontrib>Ogalo, Edith Apondi</creatorcontrib><creatorcontrib>Odhiambo, Francesca Akoth</creatorcontrib><creatorcontrib>Haas, Andreas D.</creatorcontrib><creatorcontrib>Bolton, Carolyn</creatorcontrib><creatorcontrib>Muhairwe, Josephine</creatorcontrib><creatorcontrib>Tweya, Hannock</creatorcontrib><creatorcontrib>Sylla, Mariam</creatorcontrib><creatorcontrib>D'Almeida, Marceline</creatorcontrib><creatorcontrib>Renner, Lorna</creatorcontrib><creatorcontrib>Abzug, Mark J.</creatorcontrib><creatorcontrib>Oleske, James</creatorcontrib><creatorcontrib>Purswani, Murli</creatorcontrib><creatorcontrib>Teasdale, Chloe</creatorcontrib><creatorcontrib>Nuwagaba‐Biribonwoha, Harriet</creatorcontrib><creatorcontrib>Goodall, Ruth</creatorcontrib><creatorcontrib>Leroy, Valériane</creatorcontrib><creatorcontrib>Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration</creatorcontrib><creatorcontrib>The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni 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Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Hyper Article en Ligne (HAL)</collection><collection>Hyper Article en Ligne (HAL) (Open Access)</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Freely available online</collection><collection>SwePub Articles full text</collection><jtitle>JOURNAL OF THE INTERNATIONAL AIDS SOCIETY</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jesson, Julie</au><au>Crichton, Siobhan</au><au>Quartagno, Matteo</au><au>Yotebieng, Marcel</au><au>Abrams, Elaine J.</au><au>Chokephaibulkit, Kulkanya</au><au>Le Coeur, Sophie</au><au>Aké‐Assi, Marie‐Hélène</au><au>Patel, Kunjal</au><au>Pinto, Jorge</au><au>Paul, Mary</au><au>Vreeman, Rachel</au><au>Davies, Mary‐Ann</au><au>Ben‐Farhat, Jihane</au><au>Van Dyke, Russell</au><au>Judd, Ali</au><au>Mofenson, Lynne</au><au>Vicari, Marissa</au><au>Seage, George</au><au>Bekker, Linda‐Gail</au><au>Essajee, Shaffiq</au><au>Gibb, Diana</au><au>Penazzato, Martina</au><au>Collins, Intira Jeannie</au><au>Wools‐Kaloustian, Kara</au><au>Slogrove, Amy</au><au>Powis, Kate</au><au>Williams, Paige</au><au>Matshaba, Mogomotsi</au><au>Thahane, Lineo</au><au>Nyasulu, Phoebe</au><au>Lukhele, Bhekumusa</au><au>Mwita, Lumumba</au><au>Kekitiinwa‐Rukyalekere, Adeodata</au><au>Wanless, Sebastian</au><au>Goetghebuer, Tessa</au><au>Thorne, Claire</au><au>Warszawski, Josiane</au><au>Galli, Luisa</au><au>Rossum, Annemarie M.C</au><au>Giaquinto, Carlo</au><au>Marczynska, Magdalena</au><au>Marques, Laura</au><au>Prata, Filipa</au><au>Ene, Luminita</au><au>Okhonskaya, Lyuba</au><au>Navarro, Marisa</au><au>Frick, Antoinette</au><au>Naver, Lars</au><au>Kahlert, Christian</au><au>Volokha, Alla</au><au>Chappell, Elizabeth</au><au>Pape, Jean William</au><au>Rouzier, Vanessa</au><au>Marcelin, Adias</au><au>Succi, Regina</au><au>Sohn, Annette H.</au><au>Kariminia, Azar</au><au>Edmonds, Andrew</au><au>Lelo, Patricia</au><au>Lyamuya, Rita</au><au>Ogalo, Edith Apondi</au><au>Odhiambo, Francesca Akoth</au><au>Haas, Andreas D.</au><au>Bolton, Carolyn</au><au>Muhairwe, Josephine</au><au>Tweya, Hannock</au><au>Sylla, Mariam</au><au>D'Almeida, Marceline</au><au>Renner, Lorna</au><au>Abzug, Mark J.</au><au>Oleske, James</au><au>Purswani, Murli</au><au>Teasdale, Chloe</au><au>Nuwagaba‐Biribonwoha, Harriet</au><au>Goodall, Ruth</au><au>Leroy, Valériane</au><aucorp>Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration</aucorp><aucorp>The Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis</atitle><jtitle>JOURNAL OF THE INTERNATIONAL AIDS SOCIETY</jtitle><addtitle>J Int AIDS Soc</addtitle><date>2022-03</date><risdate>2022</risdate><volume>25</volume><issue>3</issue><spage>e25871</spage><epage>n/a</epage><pages>e25871-n/a</pages><issn>1758-2652</issn><eissn>1758-2652</eissn><abstract>Introduction
Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project.
Methods
Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height‐for‐age Z‐scores (HAZ, stunting if <‐2 SD, WHO growth charts). Linear mixed‐effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex‐specific models with fractional polynomials were used to model non‐linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age.
Results
A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two‐thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub‐Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia‐Pacific; 19% overall had CD4 counts <500 cells/mm3. Across adolescence, higher HAZ was observed in females and among those in high‐income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch‐up with non‐stunted, early ART‐treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm3. This decline was observed across all regions, in males and females.
Conclusions
Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood.</abstract><cop>Switzerland</cop><pub>John Wiley & Sons, Inc</pub><pmid>35255197</pmid><doi>10.1002/jia2.25871</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0001-9103-7746</orcidid><orcidid>https://orcid.org/0000-0002-4849-181X</orcidid><orcidid>https://orcid.org/0000-0002-0140-4600</orcidid><orcidid>https://orcid.org/0000-0001-8496-6475</orcidid><orcidid>https://orcid.org/0000-0002-4478-4471</orcidid><orcidid>https://orcid.org/0000-0002-9461-2520</orcidid><orcidid>https://orcid.org/0000-0002-0209-3285</orcidid><orcidid>https://orcid.org/0000-0003-2132-6037</orcidid><orcidid>https://orcid.org/0000-0002-2818-9808</orcidid><orcidid>https://orcid.org/0000-0002-7968-9394</orcidid><orcidid>https://orcid.org/0000-0003-1053-6434</orcidid><orcidid>https://orcid.org/0000-0002-0755-4386</orcidid><orcidid>https://orcid.org/0000-0002-0784-3276</orcidid><orcidid>https://orcid.org/0000-0003-0002-681X</orcidid><orcidid>https://orcid.org/0000-0003-3176-5295</orcidid><orcidid>https://orcid.org/0000-0001-5131-3371</orcidid><orcidid>https://orcid.org/0000-0003-3542-8616</orcidid><orcidid>https://orcid.org/0000-0001-5485-8692</orcidid><orcidid>https://orcid.org/0000-0001-6952-9234</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1758-2652 |
| ispartof | JOURNAL OF THE INTERNATIONAL AIDS SOCIETY, 2022-03, Vol.25 (3), p.e25871-n/a |
| issn | 1758-2652 1758-2652 |
| language | eng |
| recordid | cdi_swepub_primary_oai_swepub_ki_se_455004 |
| source | MEDLINE; DOAJ Directory of Open Access Journals; Wiley Online Library Journals Frontfile Complete; SWEPUB Freely available online; Wiley Online Library Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Acquired immune deficiency syndrome Adolescent Adolescent development Adolescents Adult AIDS Antiretroviral agents CD4 CD4 Lymphocyte Count CD4 lymphocytes Child Child, Preschool Cohort analysis Cohort Studies Collaboration Complications and side effects Female Growth Growth Disorders - epidemiology Health aspects HIV HIV infection HIV Infections - drug therapy HIV Infections - epidemiology Human immunodeficiency virus Humans Income International aspects Life Sciences Male Pediatric research Perinatal infection perinatally acquired Sexually transmitted diseases Statistics STD Teenagers |
| title | Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis |
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