Chronic Obstructive Pulmonary Disease Is Associated with Epigenome-Wide Differential Methylation in BAL Lung Cells

DNA methylation patterns in chronic pulmonary obstructive disease (COPD) might offer new insights into disease pathogenesis. To assess methylation profiles in the main COPD target organ, we performed an epigenome-wide association study on BAL cells. Bronchoscopies were performed in 18 subjects with...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2022-06, Vol.66 (6), p.638-647
Hauptverfasser:	Eriksson Ström, Jonas, Kebede Merid, Simon, Pourazar, Jamshid, Blomberg, Anders, Lindberg, Anne, Ringh, Mikael V, Hagemann-Jensen, Michael, Ekström, Tomas J, Behndig, Annelie F, Melén, Erik
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging BAL cells Chronic obstructive pulmonary disease Deoxyribonucleic acid DNA DNA methylation DNA Methylation - genetics Epigenesis, Genetic Epigenetics Epigenome Gene expression Genetic diversity Genome-Wide Association Study Genomes Humans Lung Lung diseases Obstructive lung disease Original Research Pulmonary Disease, Chronic Obstructive - genetics
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